8,609 research outputs found
Nociceptor deletion of Tsc2 enhances axon regeneration by inducing a conditioning injury response in dorsal root ganglia
Sources of uncertainties in modelling black carbon at the global scale
Our understanding of the global black carbon (BC) cycle is essentially qualitative due to uncertainties in our knowledge of its properties. This work investigates two source of uncertainties in modelling black carbon: those due to the use of different schemes for BC ageing and its removal rate in the global Transport-Chemistry model TM5 and those due to the uncertainties in the definition and quantification of the observations, which propagate through to both the emission inventories, and the measurements used for the model evaluation. The schemes for the atmospheric processing of black carbon that have been tested with the model are (i) a simple approach considering BC as bulk aerosol and a simple treatment of the removal with fixed 70% of in-cloud black carbon concentrations scavenged by clouds and removed when rain is present and (ii) a more complete description of microphysical ageing within an aerosol dynamics model, where removal is coupled to the microphysical properties of the aerosol, which results in a global average of 40% in-cloud black carbon that is scavenged in clouds and subsequently removed by rain, thus resulting in a longer atmospheric lifetime. This difference is reflected in comparisons between both sets of modelled results and the measurements. Close to the sources, both anthropogenic and vegetation fire source regions, the model results do not differ significantly, indicating that the emissions are the prevailing mechanism determining the concentrations and the choice of the aerosol scheme does not influence the levels. In more remote areas such as oceanic and polar regions the differences can be orders of magnitude, due to the differences between the two schemes. The more complete description reproduces the seasonal trend of the black carbon observations in those areas, although not always the magnitude of the signal, while the more simplified approach underestimates black carbon concentrations by orders of magnitude. The sensitivity to wet scavenging has been tested by varying in-cloud and below-cloud removal. BC lifetime increases by 10% when large scale and convective scale precipitation removal efficiency are reduced by 30%, while the variation is very small when below-cloud scavenging is zero. Since the emission inventories are representative of elemental carbon-like substance, the model output should be compared to elemental carbon measurements and if known, the ratio of black carbon to elemental carbon mass should be taken into account when the model is compared with black carbon observation
The high-pressure behavior of CaMoO4
We report a high-pressure study of tetragonal scheelite-type CaMoO4 up to 29
GPa. In order to characterize its high-pressure behavior, we have combined
Raman and optical-absorption measurements with density-functional theory
calculations. We have found evidence of a pressure-induced phase transition
near 15 GPa. Experiments and calculations agree in assigning the high-pressure
phase to a monoclinic fergusonite-type structure. The reported results are
consistent with previous powder x-ray-diffraction experiments, but are in
contradiction with the conclusions obtained from earlier Raman measurements,
which support the existence of more than one phase transition in the pressure
range covered by our studies. The observed scheelite-fergusonite transition
induces significant changes in the electronic band gap and phonon spectrum of
CaMoO4. We have determined the pressure evolution of the band gap for the low-
and high-pressure phases as well as the frequencies and pressure dependences of
the Raman-active and infrared-active modes. In addition, based upon
calculations of the phonon dispersion of the scheelite phase, carried out at a
pressure higher than the transition pressure, we propose a possible mechanism
for the reported phase transition. Furthermore, from the calculations we
determined the pressure dependence of the unit-cell parameters and atomic
positions of the different phases and their room-temperature equations of
state. These results are compared with previous experiments showing a very good
agreement. Finally, information on bond compressibility is reported and
correlated with the macroscopic compressibility of CaMoO4. The reported results
are of interest for the many technological applications of this oxide.Comment: 36 pages, 10 figures, 8 table
Spin-orbit-enhanced Wigner localization in quantum dots
We investigate quantum dots with Rashba spin-orbit coupling in the
strongly-correlated regime. We show that the presence of the Rashba interaction
enhances the Wigner localization in these systems, making it achievable for
higher densities than those at which it is observed in Rashba-free quantum
dots. Recurring shapes in the pair-correlated densities of the yrast spectrum,
which might be associated with rotational and vibrational modes, are also
reported.Comment: 5 pages, 4 figure
Miglioramento dell'efficienza tecnica e ambientale degli adesivi utilizzati nel settore del mobile
Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair
Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood. We previously showed that the adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for SC development and myelination. Interestingly, the expression of Gpr126 is maintained in adult SCs, suggestive of a function in the mature nerve. We therefore investigated the role of Gpr126 in nerve repair by studying an inducible SC-specific Gpr126 knock-out mouse model. Here, we show that remyelination is severely delayed after nerve-crush injury. Moreover, we also observe noncell-autonomous defects in macrophage recruitment and axon regeneration in injured nerves following loss of Gpr126 in SCs. This work demonstrates that Gpr126 has critical SC-autonomous and SC-nonautonomous functions in remyelination and peripheral nerve repair. SIGNIFICANCE STATEMENT Lack of robust remyelination represents one of the major barriers to recovery of neurological functions in disease or following injury in many disorders of the nervous system. Here we show that the adhesion class G protein-coupled receptor (GPCR) Gpr126/Adgrg6 is required for remyelination, macrophage recruitment, and axon regeneration following nerve injury. At least 30% of all approved drugs target GPCRs; thus, Gpr126 represents an attractive potential target to stimulate repair in myelin disease or following nerve injury
Step-by-step design of new theranostic nanoformulations: Multifunctional nanovectors for radio-chemo-hyperthermic therapy under physical targeting
Organic matter in forest arrangements within the Crop-Livestock-Forest Integration System in Mato Grosso State.
In Mato Grosso State, the main objectives of this integration are the shading provided to the animals, the improvement in the pastures? fertility, and the availability of wood for use at the property
Soil P, K, and Al contents in a Crop-Livestock-Forest integration system in Mato Grosso State.
The objective of this study was to evaluate the soil P, K, and Al contents in a CLFi system established in Nova Canaã do Norte-MT, Brazil
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