Acute sodium overload produces renal tubulointerstitial inflammation in normal rats

The aim of the present study was to determine whether acute sodium overload could trigger an inflammatory reaction in the tubulointerstitial (TI) compartment in normal rats. Four groups of Sprague-Dawley rats received increasing NaCl concentrations by intravenous infusion. Control (C): Na + 0.15M; G1: Na+ 0.5M; G2: Na+ 1.0M; and G3: Na+ 1.5M. Creatinine clearance, mean arterial pressure (MAP), renal blood flow (RBF), and sodium fractional excretion were determined. Transforming growth factor β1 (TGF-β1), α-smooth muscle actin (α-SMA), RANTES, transcription factor nuclear factor-kappa B (NF-κB), and angiotensin II (ANG II) were evaluated in kidneys by immunohistochemistry. Animals with NaCl overload showed normal glomerular function without MAP and RBF modifications and exhibited a concentration-dependent natriuretic response. Plasmatic sodium increased in G2 (P G2>C group. These results suggest that an acute sodium overload is able 'per se' to initiate TI endothelial inflammatory reaction (glomerular and peritubular) and incipient fibrosis in normal rats, independently of hemodynamic modifications. Furthermore, these findings are consistent with the possibility that activation of NF-κB and local ANG II may be involved in the pathway of this inflammatory process.Fil: Roson, Maria Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cavallero, Carmen Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Della Penna, Silvana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Cao, Gabriel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Alemán; ArgentinaFil: Gorzalczany, Susana Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Pandolfo, Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Kuprewicz, A.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Canessa, O.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Toblli, Jorge Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Alemán; ArgentinaFil: Fernandez, Belisario Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentin

Gestión y transferencia del conocimiento en una universidad pública del conurbano bonaerense.

Se propone, a través de esta experiencia en ejecución, describir el estado de avance y factibilidad de impacto de un proyecto de investigación denominado “Gestión y Transferencia del Conocimiento”, código 55B PIDC/184, el que integra el Programa de Investigación: “Gestión y Vinculación del Conocimiento en Ciencia y Tecnología en el marco de una universidad pública del conurbano bonaerense, y continúa la línea de investigación iniciada con los proyectos de investigación 55B PIDC/168 “Gestión del Conocimiento” (2012-2013) y 55B PIDC/169 “Vinculación del Conocimiento” (2012- 2013), ejecutados como Proyectos de Investigación con Dependencia Compartida (PIDC) entre el Departamento de Ciencias Económicas y la Secretaría de Ciencia y Tecnología en la misma universidad. El presente proyecto tiene como objetivo general el desarrollo de actividades de investigación en el marco de cuatro áreas centrales de intervención en el diseño de políticas y procedimientos de gestión en Ciencia y Tecnología a saber: I-Gestión de la investigación científica y tecnológica, II-Gestión de la investigación, III-Formación de Recursos Humanos y IV-Transferencia y vinculación del conocimiento. Estas cuatro áreas de intervención y desarrollo en materia de política y gestión de la ciencia y la tecnología formarán parte de un Plan de Desarrollo Institucional de fortalecimiento y mejora permanente del conjunto de actividades que desarrolla la universidad, en pos de una mayor producción y transferencia de conocimiento al conjunto de la Universidad, sector productivo y comunidad universitaria, de parte del conjunto de docentes investigadores, núcleos de investigación, programas y proyectos dedicados a atender las distintas demandas de producción de conocimiento del conjunto de la comunidad universitaria intra y extra universidad. La perspectiva desde la que se realiza esta investigación, integra los aspectos epistemológicos, históricos y sociales, en los que se pondrán en juego criterios científicos, sociales, éticos, pedagógicos y culturales. La meta, desde una perspectiva de gestión y transferencia del conocimiento, es asegurar la pertinencia académica y social de los saberes que se producen y transmiten en la Universidad, y con ello crear una “cultura del conocimiento” que permita subsumir las otras culturas universitarias en un proyecto al servicio de la sociedad. Se comunicará, en el contexto de esta investigación, los alcances logrados en materia de fortalecimiento de la transferencia de conocimiento a partir de la definición y aplicación de políticas de gestión de la ciencia y la tecnología bajo el modelo de “Gestión del Conocimiento”.publishedVersio

Trabajo global y desigualdades en el mercado laboral

La globalización neoliberal fomentó una paradójica tensión entre las supuestas tendencias hacia la homogeneización y uniformización social, y la aparición de nuevas desigualdades sociales. La sociedad actual, lejos de experimentar las consecuencias del llamado "fin del trabajo", expresa sus efectos en cuanto a las formas d gestión laboral promovidas, la flexibilización, la desregularización de las relaciones laborales y la pérdida de calidad de las ocupaciones

Os registros conventuais como fonte para a história econômica: Aproximações metodológicas a partir do caso de Santa Fé (Argentina), 1700-1850

Objetivo/contexto: El artículo pone el foco en una problemática común a la historia económica de América Latina preestadística: la carestía de fuentes y las dificultades metodológicas para estudiar la evolución de los niveles de vida en el largo plazo. Metodología: Se parte para ello de un estudio de caso, la ciudad de Santa Fe, un enclave comercial del Río de la Plata tardocolonial, donde se asentaron cuatro órdenes religiosas desde el siglo XVII. Se exponen series seculares (1700-1850) de precios de dos alimentos básicos (yerba mate y azúcar), elaboradas a partir de libros contables de conventos, con la intención de demostrar las ventajas y las dificultades que presenta esta fuente para el estudio de los hábitos de consumo, la evolución de los precios de los alimentos y de las condiciones de vida en determinados ámbitos urbanos de la época colonial. La presentación incluye comparaciones de los precios en distintos conventos a lo largo del período, y se discuten específicamente las dificultades para la construcción de índices ponderados. Originalidad: Si bien se trata de una fuente ampliamente utilizada por la literatura académica que analizó el período, nunca se habían realizado comparaciones específicas entre las contabilidades de las distintas órdenes religiosas, en particular para una ciudad periférica del Virreinato del Río de la Plata. Conclusiones: Los resultados obtenidos no sólo muestran la utilidad de la fuente, sino también evidencian las dificultades que existen para la construcción de series que permitan analizar niveles de vida en el largo plazo. Alertan en este sentido sobre la necesidad de estudiar detalladamente las particularidades de cada caso antes de realizar grandes comparaciones internacionales.Objective/context: This article focuses on a problem common to the pre-statistical economic history of Latin America: the scarcity of sources and the methodological difficulties in studying the evolution of standards of living over time. Methodology: We begin with a case study done on the city of Santa Fe, a commercial enclave of the late-colonial Río de la Plata, where four religious orders had settled since the 17th century. Long-term records (1700-1850) from accounting books of convents, which included prices of two basic foodstuffs (yerba mate and sugar), are shown in order to demonstrate the advantages and difficulties of using this source in studying habits of consumption, the evolution of food prices and living conditions in certain urban areas of the colonial era. The exposition includes comparisons of the prices in different convents throughout the period, and specifically discusses the challenges in constructing the weighted indexes. Originality: Although these records are widely used by the academic literature analyzing this period, no specific comparisons had been made between the accounts of the different religious orders, particularly for a peripheral city of the Viceroyalty of the Río de la Plata. Conclusions: The final results show not only the usefulness of the source, but also the difficulties in constructing long run series to analyze living standards. Specific and detailed case studies are useful tools in order to improve broad international comparisons.Objetivo/contexto: O artigo coloca o foco numa problemática comum à história econômica da América Latina do período pré-estatístico: a falta de fontes e as dificuldades metodológicas para estudar a evolução dos níveis de vida a longo prazo. Metodologia: Para isso, parte-se de um estudo de caso: a cidade de Santa Fé, uma estratégica praça comercial do Rio da Prata no período colonial tardio, onde desde o século XVII se instalaram quatro ordens religiosas desde o século XVII. Apresentam-se séries seculares (1700-1850) de preços de dois alimentos básicos (erva-mate e açúcar), elaboradas a partir de livros contábeis de conventos, com a intenção de demonstrar as vantagens e as dificuldades que essa fonte apresenta para o estudo dos hábitos de consumo, da evolução dos preços dos alimentos e das condições de vida em determinados âmbitos urbanos da época colonial. O estudo inclui comparações dos preços em diferentes conventos ao longo do período e analisa vários quesitos que devem ser atendidos na construção de índices ponderados. Originalidade: Apesar de ser uma fonte amplamente utilizada pela literatura acadêmica que analisou o período, nunca foram realizadas comparações específicas entre as contabilidades das diferentes ordens religiosas, em particular para uma cidade periférica do Vice-reinado do Rio da Prata. Conclusões: Os resultados obtidos não somente mostram a utilidade da fonte, mas também evidenciam as dificuldades que existem para a construção de séries que permitam analisar níveis de vida a longo prazo. Alertam, nesse sentido, sobre a necessidade de estudar detalhadamente as peculiaridades de cada caso antes de realizar grandes comparações internacionais.Fil: Djenderedjian, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto de Historia Argentina y Americana "Dr. Emilio Ravignani". Universidad de Buenos Aires. Facultad de Filosofía y Letras. Instituto de Historia Argentina y Americana "Dr. Emilio Ravignani"; ArgentinaFil: Frid, Carina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario; ArgentinaFil: Martiren, Juan Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto de Historia Argentina y Americana "Dr. Emilio Ravignani". Universidad de Buenos Aires. Facultad de Filosofía y Letras. Instituto de Historia Argentina y Americana "Dr. Emilio Ravignani"; Argentin

Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires

The production of tt‾ , W+bb‾ and W+cc‾ is studied in the forward region of proton–proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fb−1 . The W bosons are reconstructed in the decays W→ℓν , where ℓ denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of $t\overline{t}$, $W+b\overline{b}$ and $W+c\overline{c}$ is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 $\pm$ 0.02 \mbox{fb}^{-1}. The $W$ bosons are reconstructed in the decays $W\rightarrow\ell\nu$, where $\ell$ denotes muon or electron, while the $b$ and $c$ quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages

Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages

Observation of the B0 → ρ0ρ0 decay from an amplitude analysis of B0 → (π+π−)(π+π−) decays

Proton–proton collision data recorded in 2011 and 2012 by the LHCb experiment, corresponding to an integrated luminosity of 3.0 fb−1 , are analysed to search for the charmless B0→ρ0ρ0 decay. More than 600 B0→(π+π−)(π+π−) signal decays are selected and used to perform an amplitude analysis, under the assumption of no CP violation in the decay, from which the B0→ρ0ρ0 decay is observed for the first time with 7.1 standard deviations significance. The fraction of B0→ρ0ρ0 decays yielding a longitudinally polarised final state is measured to be fL=0.745−0.058+0.048(stat)±0.034(syst) . The B0→ρ0ρ0 branching fraction, using the B0→ϕK⁎(892)0 decay as reference, is also reported as B(B0→ρ0ρ0)=(0.94±0.17(stat)±0.09(syst)±0.06(BF))×10−6

Precise measurements of the properties of the B-1(5721)(0,+) and B-2*(5747)(0,+) states and observation of B-+,B-0 pi(-,+) mass structures

Invariant mass distributions of $B^+\pi^-$ and $B^0\pi^+$ combinations are investigated in order to study excited B mesons. The analysis is based on a data sample corresponding to $3.0 fb^{-1}$ of $pp$ collision data, recorded by the LHCb detector at centre-of-mass energies of 7 and 8 TeV. Precise measurements of the masses and widths of the $B_1(5721)^{0,+}$ and $B_2^*(5747)^{0,+}$ states are reported. Clear enhancements, particularly prominent at high pion transverse momentum, are seen over background in the mass range $5850$-$6000$ MeV in both $B^+\pi^-$ and $B^0\pi^+$ combinations. The structures are consistent with the presence of four excited B mesons, labelled $B_J(5840)^{0,+}$ and $B_J(5960)^{0,+}$, whose masses and widths are obtained under different hypotheses for their quantum numbers.Invariant mass distributions of B$^{+}$ π$^{−}$ and B$^{0}$ π$^{+}$ combinations are investigated in order to study excited B mesons. The analysis is based on a data sample corresponding to 3.0 fb$^{−1}$ of pp collision data, recorded by the LHCb detector at centre-of-mass energies of 7 and 8 TeV. Precise measurements of the masses and widths of the B$_{1}$(5721)$^{0,+}$ and B$^{2}$(5747)$^{0,+}$ states are reported. Clear enhancements, particularly prominent at high pion transverse momentum, are seen over background in the mass range 5850-6000 MeV in both B$^{+}$ π$^{−}$ and B$^{0}$ π$^{+}$ combinations. The structures are consistent with the presence of four excited B mesons, labelled B$_{J}$ (5840)$^{0,+}$ and B$_{J}$ (5960)$^{0,+}$, whose masses and widths are obtained under different hypotheses for their quantum numbers.Invariant mass distributions of B+pi- and B0pi+ combinations are investigated in order to study excited B mesons. The analysis is based on a data sample corresponding to 3.0 fb-1 of pp collision data, recorded by the LHCb detector at centre-of-mass energies of 7 and 8 TeV. Precise measurements of the masses and widths of the B_1(5721)^(0,+) and B_2*(5747)^(0,+) states are reported. Clear enhancements, particularly prominent at high pion transverse momentum, are seen over background in the mass range 5850--6000 MeV in both B+pi- and B0pi+ combinations. The structures are consistent with the presence of four excited B mesons, labelled B_J(5840)^(0,+) and B_J(5960)^(0,+), whose masses and widths are obtained under different hypotheses for their quantum numbers