Responses of Serum Lipids and Lipoproteins Following Power-based Resistance Training in Athletes

Athletes often participate in power-based resistance training to improve their athletic performance by simultaneously enhancing strength and power. However, it is unclear whether athletes participating in power-based resistance training can positively alter serum lipid and lipoprotein profiles. Thus, the current study investigated the effects of power-based resistance training on serum lipid and lipoprotein profiles in athletes. Twenty-one healthy collegiate athletes, 12 female soccer players and 9 male football players, between the ages of 18 and 23, participated in the study during the off-season. The power-based resistance training program consisted of a variety of Olympic-style and traditional weightlifting movements along with plyometrics, and was performed for 4 days a week for 6 weeks, with each workout lasting roughly 60 minutes. One-repetition maximum (1-RM) was tested for clean, incline press, and Olympic-style back squat (angle of knee \u3c 90°), and the following weekly undulating periodization was used: week 1 – 70% 1-RM, week 2 – 80% 1-RM, week 3 – 75% 1-RM, week 4 – 90% 1-RM, week 5 – 80% 1-RM, and week 6 – 95% 1-RM. Overnight fasting blood samples were collected before and after the 6-weeks of training to analyze serum lipid and lipoprotein parameters, including TG, TC, VLDL-C, LDL-C, HDL-C, Lp(a), and ox-LDL. A 2 (groups: males and females) X 2 (time: pre- and post-training) repeated measures ANOVA with pairwise comparisons was employed. A p-value of \u3c 0.05 was set for the statistical significance. Serum lipid and lipoprotein parameters remained unchanged, except for ox-LDL, which significantly (p = 0.036) decreased by 1.87 U·L-1 or 3.81% (from 49.05 ± 9.17 to 47.18 ± 9.78 U·L-1) following the 6-weeks of power-based resistance training. Thus, 6-weeks of power-based resistance training can significantly lower ox-LDL, and this exercise-induced reduction in ox-LDL may confer a cardioprotective health benefit by decreasing the progression of atherosclerotic events and the pro-inflammatory state within atherosclerotic lesions

Assessing the Costs and Environmental Consequences of Agricultural Land Use Changes: A Site-Specific, Policy-Scale Modeling Approach

The growth in federal conservation programs has created a need for policy modeling frameworks capable of measuring micro-level behavioral responses and macro-level landscape changes. This paper presents an empirical model that predicts crop choices, crop rotations, and conservation tillage adoption as a function of conservation payment levels, profits, and other variables at more than 42,000 agricultural sites of the National Resource Inventory (NRI) in the Upper Mississippi River Basin. Predicted changes in crop choices and tillage practices are then fed into site-specific environmental production functions to determine changes in nitrate runoff and leaching and in water and wind erosion at each NRI site. This policy-scale model is applied to the case of green payments for the adoption of conservation practices (conservation tillage and crop rotations) in the Upper Mississippi River Basin, a region under scrutiny as a significant source of nutrient loadings to the Mississippi River, causing hypoxia in the Gulf of Mexico. Results from this application suggest that payments for conservation tillage and crop rotations increase the use of these conservation practices. However, the acreage response is inelastic and the programs are not likely to be cost effective on their own for addressing the hypoxia problem in the Gulf of Mexico.agricultural policy, conservation practices, green payments, land use changes, nitrate runoff and leaching, non-point pollution, soil erosion.

Assessing the Costs and Environmental Consequences of Agricultural Land Use Changes: A Site-Specific, Policy-Scale Modeling Approach

The growth in federal conservation programs has created a need for policy modeling frameworks capable of measuring micro-level behavioral responses and macro-level landscape changes. This paper presents an empirical model that predicts crop choices, crop rotations, and conservation tillage adoption as a function of conservation payment levels, profits, and other variables at more than 42,000 agricultural sites of the National Resource Inventory (NRI) in the Upper Mississippi River Basin. Predicted changes in crop choices and tillage practices are then fed into site-specific environmental production functions to determine changes in nitrate runoff and leaching and in water and wind erosion at each NRI site. This policy-scale model is applied to the case of green payments for the adoption of conservation practices (conservation tillage and crop rotations) in the Upper Mississippi River Basin, a region under scrutiny as a significant source of nutrient loadings to the Mississippi River, causing hypoxia in the Gulf of Mexico. Results from this application suggest that payments for conservation tillage and crop rotations increase the use of these conservation practices. However, the acreage response is inelastic and the programs are not likely to be cost effective on their own for addressing the hypoxia problem in the Gulf of Mexico

Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics

Chronic lymphocytic leukemia (CLL) has been consistently at the forefront of genetic research owing to its prevalence and the accessibility of sample material. Recently, genome-wide technologies have been intensively applied to CLL genetics, with remarkable progress. Single nucleotide polymorphism arrays have identified recurring chromosomal aberrations, thereby focusing functional studies on discrete genomic lesions and leading to the first implication of somatic microRNA disruption in cancer. Next-generation sequencing (NGS) has further transformed our understanding of CLL by identifying novel recurrently mutated putative drivers, including the unexpected discovery of somatic mutations affecting spliceosome function. NGS has further enabled in-depth examination of the transcriptional and epigenetic changes in CLL that accompany genetic lesions, and has shed light on how different driver events appear at different stages of disease progression and clonally evolve with relapsed disease. In addition to providing important insights into disease biology, these discoveries have significant translational potential. They enhance prognosis by highlighting specific lesions associated with poor clinical outcomes (for example, driver events such as mutations in the splicing factor subunit gene SF3B1) or with increased clonal heterogeneity (for example, the presence of subclonal driver mutations). Here, we review new genomic discoveries in CLL and discuss their possible implications in the era of precision medicine

Boosting leukemia-specific T cell responses in patients following stem cell transplantation

Whole tumor cell-based vaccines administered within the first 2 to 3 months after allogeneic stem cell transplantation stand out as a promising approach to enhance graft-vs.-leukemia responses. Herein, the implications of this finding for the development of strategies to improve the outcome of patients subjected to allogeneic stem cell transplantation are discussed

Neural Control of Maternal and Paternal Behaviors

Parental care, including feeding and protection of young, is essential for the survival as well as mental and physical well-being of the offspring. A large variety of parental behaviors has been described across species and sexes, raising fascinating questions about how animals identify the young and how brain circuits drive and modulate parental displays in males and females. Recent studies have begun to uncover a striking antagonistic interplay between brain systems underlying parental care and infant-directed aggression in both males and females, as well as a large range of intrinsic and environmentally driven neural modulation and plasticity. Improved understanding of the neural control of parental interactions in animals should provide novel insights into the complex issue of human parental care in both health and disease.Molecular and Cellular BiologyOther Research Uni

Spectroscopy of broad absorption line quasars at 3≲z≲53\lesssim z \lesssim 5 -- I: evidence for quasar winds shaping broad/narrow emission line regions

We present an observational study of 22 broad absorption line quasars (BAL QSOs) at $3\lesssim z \lesssim5$ based on optical/near-IR spectroscopy, aiming to investigate quasar winds and their effects. The near-IR spectroscopy covers the \hb\ and/or \mgii\ broad emission lines (BELs) for these quasars, allowing us to estimate their central black hole (BH) masses in a robust way. We found that our BAL QSOs on average do not have a higher Eddington ratio than that from non-BAL QSOs matched in redshift and/or luminosity. In a subset consisting of seven strong BAL QSOs possessing sub-relativistic BAL outflows, we see the prevalence of large \civ-BEL blueshift ($\sim$3100 km s$^{-1}$) and weak \oiii\ emission (particularly the narrow \oiii$\lambda$5007 component), indicative of nuclear outflows affecting the narrow emission-line (NEL) regions. In another subset consisting of thirteen BAL QSOs having simultaneous observations of \mgii\ and \hb, we found a strong correlation between 3000~\AA\ and 5000~\AA\ monochromatic luminosity, consistent with that from non-BAL QSOs matched in redshift and luminosity; however, there is no correlation between \mgii\ and \hb\ in FWHM, likely due to nuclear outflows influencing the BEL regions. Our spectroscopic investigations offer strong evidence that the presence of nuclear outflows plays an important role in shaping the BEL/NEL regions of these quasars and possibly, regulating the growth of central supermassive black holes (SMBHs). We propose that BEL blueshift and BAL could be different manifestations of the same outflow system viewed at different sightlines and/or phases.Comment: 13 pages, 10 figures. Accepted for publication in Ap

Personal neoantigen cancer vaccines: The momentum builds

Neoantigen-based cancer vaccines designed to target the unique immunogenic mutations arising in each patient’s tumor are breathing new life into a struggling approach. Data continue to demonstrate the importance of neoantigens in immune control of cancer. Despite manufacturing complexity, outstanding questions and desired further improvements, neoantigen vaccines are currently undergoing clinical evaluation

Perivascular mast cells regulate vein graft neointimal formation and remodeling

Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graft neointimal lesion formation, using an optimized local mast cell reconstitution method. Methods and Results. Neointimal hyperplasia was induced by insertion of a vein graft into the right carotid artery in wild type and mast cell deficient KitW−sh/W−sh mice. In some experiments, mast cells were reconstituted systemically (tail vein injection of bone marrow-derived mast cells) or locally (directly into the right neck area) prior to vein grafting. Vein graft neointimal lesion formation was significantly (P < 0.05) reduced in KitW−sh/W−sh mice. Mast cell deficiency reduced the number of proliferating cells, and inhibited L-selectin, CCL2, M-CSF and MIP-3α expression in the vein grafts. Local but not systemic mast cell reconstitution restored a perivascular mast cell population that subsequently promoted neointimal formation in mast cell deficient mice. Conclusion. Our data demonstrate that perivascular mast cells play a key role in promoting neointima formation by inducing local acute inflammatory and proliferative responses. These results suggest that ex vivo intraoperative targeting of mast cells may have therapeutic potential for the prevention of pathological vein graft remodeling