Pyrazole derivatives for treating conditions mediated by activation of the adenosine a2b or a3 receptor

Compounds of formula (I) in free or salt form, wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating a condition mediated by activation of the adenosine Alb receptor or the adenosine A3 receptor, particularly an inflammatory or obstructive airways disease. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described

5-phenylthiazole derivatives and their use as p13 kinase inhibitors

Compounds of formula (I) in free or salt form, wherein R1, R2, R3, Wand R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described

5-phenyl-4-methyl-thiazol-2-yl-amine derivatives as inhibitors of phosphatidylinositol 3 kinase enzymes (pi3) for the treatment of inflammatory airway diseases

Compounds of Formula (I) in free or salt form, wherein Ra, Rb, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase such as inflammatory airway diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described

Relative gene expression in <i>Fucus vesiculosus</i> in controlled condition (white square) and exposed to UV-B (black square) during 72 hours are presented for <i>pksIII</i> (a), <i>ast6</i> (b), <i>hsp70</i> (c), and <i>vbpo</i> (d).

<p>The expression of a gene is normalized to the geometric mean of the expression of 2 reference genes (<i>ef1α</i>, <i>tua</i>) in the same algal sample and to the mean of its expression in the three control algae at each time point. Values represent means of three independent replicates and bars represent the SE. Letters indicate significant difference (LSMEANS 0.05).</p

Organic compounds for the treatment of imflammatory or alleric conditions

No description supplie

Photosynthesis efficiency of <i>Fucus vesiculosus</i> under chronic exposure to UV-B radiation during 4 weeks.

<p>The optimal quantum yield (Fv/Fm) of apical parts of <i>F</i>.<i>vesiculosus</i> thalli measured through imaging PAM fluorimetry during exposure to PAR (controls, white losanges) and UV-B condition (black squares).Values represent means of three independent replicates and bars represent the SE. Statistically significant differences (LSMEANS 0.05) between treatments are indicated by stars (*).</p

Quantification of total soluble phenol contents (mg equivalent phloroglucinol.g^-1 DW) before purification in controlled condition (white square) and exposed to UV-B (black square).

<p>Values represent means of three independent replicates and bars represent the SD.</p

X‑ray Diffraction and Density Functional Theory Provide Insight into Vanadate Binding to Homohexameric Bromoperoxidase II and the Mechanism of Bromide Oxidation

X-ray diffraction of native bromoperoxidase II (EC 1.11.1.18) from the brown alga <i>Ascophyllum nodosum</i> reveals at a resolution of 2.26 Å details of orthovanadate binding and homohexameric protein organization. Three dimers interwoven in contact regions and tightened by hydrogen-bond-clamped guanidinium stacks along with regularly aligned water molecules form the basic structure of the enyzme. Intra- and intermolecular disulfide bridges further stabilize the enzyme preventing altogether the protein from denaturing up to a temperature of 90 °C, as evident from dynamic light scattering and the on-gel <i>ortho</i>-dianisidine assay. Every monomer binds one equivalent of orthovanadate in a cavity formed from side chains of three histidines, two arginines, one lysine, serine, and tryptophan. Protein binding occurs primarily through hydrogen bridges and superimposed by Coulomb attraction according to thermochemical model on density functional level of theory (B3LYP/6-311++G**). The strongest attractor is the arginine side chain mimic <i>N</i>-methylguanidinium, enhancing in positive cooperative manner hydrogen bridges toward weaker acceptors, such as residues from lysine and serine. Activating hydrogen peroxide occurs in the thermochemical model by side-on binding in orthovanadium peroxoic acid, oxidizing bromide with virtually no activation energy to hydrogen bonded hypobromous acid

Quantification of soluble phenol contents in semi-purified phlorotannins fractions (mg equivalent phloroglucinol.g^-1 DW) in controlled condition (white square) and exposed to UV-B (black square).

<p>Values represent means of three independent replicates and bars represent the SD. Mean with different letters indicate significant difference between all samples along the kinetic (LSMEANS 0.05). Stars (*) indicate significant difference between control and UV-B treatment (LSMEANS 0.05).</p

Primers used for the qRT-PCR analysis on control and UV-B conditions.

<p>Primers used for the qRT-PCR analysis on control and UV-B conditions.</p