Module-trait relationships.

<p>(<b>A</b>) mRNA module MEs are correlated (Pearson) to AD case-status (Class), brain pH, PMI, Age, RIN and subject smoking status to assess for confounding. P-values shown are unadjusted for multiple testing. After adjusting for number of modules tested, ME_{<i>turquoise</i>}, ME_{<i>yellow</i>}, ME_{<i>grey60</i>}, ME_<i>pink</i>, ME_<i>green</i> and ME_{<i>salmon</i>} are significantly correlated with AD case-status (Class). (<b>B</b>). Similarly, after adjusting p-values for number of modules tested, miRNAs ME_{<i>yellow</i>}, ME_<i>blue</i> and ME_<i>brown</i> modules are significantly correlated with AD case-status (Class).</p

eQTL (chr2:170783092:D) effect on the expression of the glutamate decarboxylase (GAD1) gene.

<p>The bar plot depicts the differential expression of GAD1 among homozygote for the major (11, red), heterozygote (12, green) and homozygote for the minor alleles (22, blue) subjects.</p

(A). rs11626307 effect on the hsa-miR-134-5p (A) and hsa-miR-370-3p (B) expressions.

<p>(A). rs11626307 effect on the hsa-miR-134-5p (A) and hsa-miR-370-3p (B) expressions.</p

(A) Cluster dendrogram and module assignment for mRNA modules from WGCNA. Topological overlap dissimilarity measure is clustered by average linkage hierarchical clustering and module assignments (dynamic hybrid algorithm) are denoted in the color bar (bottom). 4571 transcripts were assigned to one of 24 modules including Mgrey. (B). Following the same outline, 240 miRNAs are assigned to one of 12 modules indicated by color (including Mgrey).

<p>(A) Cluster dendrogram and module assignment for mRNA modules from WGCNA. Topological overlap dissimilarity measure is clustered by average linkage hierarchical clustering and module assignments (dynamic hybrid algorithm) are denoted in the color bar (bottom). 4571 transcripts were assigned to one of 24 modules including Mgrey. (B). Following the same outline, 240 miRNAs are assigned to one of 12 modules indicated by color (including Mgrey).</p

Brain list enrichment for cell type specific modules.

<p>Brain list enrichment for cell type specific modules.</p