Effect of H3 haplocopy on lipid traits (mean ± SD).

<p>Effect of H3 haplocopy on lipid traits (mean ± SD).</p

Association between median lipid traits and single SNPs, using an extended region of interest (p-values from a linear regression model in PLINK).

<p>Association between median lipid traits and single SNPs, using an extended region of interest (p-values from a linear regression model in PLINK).</p

Patient characteristics.

<p>T CHOL: total cholesterol; LDL-C: low density lipoprotein cholesterol; HDL-C: high density lipoprotein cholesterol; TG: triglyceride.</p

Association between modeled lipid trait and single SNPs, over the same extended region of interest shown in Table 4 (Kruskal-Wallis p-values are shown).

<p>Association between modeled lipid trait and single SNPs, over the same extended region of interest shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015779#pone-0015779-t004" target="_blank">Table 4</a> (Kruskal-Wallis p-values are shown).</p

Association between CNR1 haplotype and median lipid traits (p-values are shown, calculated using a linear regression model in PLINK).

<p>*adjusted by age, gender, BMI, calories from fat and sport index.</p>†<p>Designation in Tes Baye paper (2008).</p>§<p>SNPs that used for haplotype construction (5′-3′): rs806370, rs806369, rs1049353, rs12720071, rs806368, rs806366.</p

Replication and refinement of the model (p-values are shown, calculated using a linear regression model in PLINK).

<p>Replication and refinement of the model (p-values are shown, calculated using a linear regression model in PLINK).</p

Scatterplot showing the relationship between BMI and dietary fat intake for PMRP participants.

<p>Using the entire PMRP biobank<b> (n = 20,000)</b>, percentage of daily calories due to fat has been plotted against BMI at the time of study entry. Trend-line is added (r = 0.086).</p

Gender stratified distribution of Body Mass Index (BMI) within the entire population-based PMRP biobank.

<p>All subjects with BMI>40 kg/m² (n = 477 female participants, and 168 male participants) were included in the current study cohort.</p

Tag SNP minor allele frequencies.

<p>All SNPs used for haplotype construction are bold.</p>1<p>anticipated MAF based on CEPH cohort (abstracted from ABI website/product catalog).</p>2<p>observed MAF within 645 PMRP study subjects with Class 3 Obesity (BMI>40 kg/m²).</p

Principal component analysis (PCA) of 5090 samples (glaucoma cases and controls) from eMERGE network.

<p>Eigenvector 1 is on x-axis and eigenvector 2 is on y-axis. Each point is a sample and they are color coded by case and control status.</p