Baseline characteristics stratified according to tertiles of CASP-12 scores (lowest, middle and highest subjective wellbeing) Total N = 12,246.

<p>Baseline characteristics stratified according to tertiles of CASP-12 scores (lowest, middle and highest subjective wellbeing) Total N = 12,246.</p

Childhood circumstances among members of the MRC National Survey of Health and Development who provided mental wellbeing data in 2006–11.

<p><b>Notes:</b> mean (sd) = mean (standard deviation)</p><p>Childhood circumstances among members of the MRC National Survey of Health and Development who provided mental wellbeing data in 2006–11.</p

Odds ratios and 95% CIs for the relation of between common mental disorder among non-obese subjects at baseline (1984) and the development of global or abdominal obesity at re-survey (1991).

<p>GHQ: 30 items General health questionnaire. BMI: body mass index. WC: waist circumference.</p><p>Multinomial logistic regression models were used with subjects having a body mass index between 18.5 and 24.9 kg/m² (both gender) or a waist circumference < 94 cm (men) /80 cm (women) being the reference.</p><p>Model 1: Adjusted for baseline age</p><p>Model 2: adjusted for baseline age, marital status, socio-economic status, alcohol consumption, tobacco smoking and physical activity.</p><p>Odds ratios and 95% CIs for the relation of between common mental disorder among non-obese subjects at baseline (1984) and the development of global or abdominal obesity at re-survey (1991).</p

Odds ratios and 95% CIs for the relation between general or abdominal obesity among subjects free of common mental disorders at baseline (1984) and the development of common mental disorders at the re-survey study (1991).

<p>GHQ: 30 items General health questionnaire. BMI: body mass index. WC: waist circumference.</p><p>Model 1: Adjusted for baseline age</p><p>Model 2: adjusted for baseline age, marital status, socio-economic status, alcohol consumption, tobacco smoking and physical activity.</p><p>Odds ratios and 95% CIs for the relation between general or abdominal obesity among subjects free of common mental disorders at baseline (1984) and the development of common mental disorders at the re-survey study (1991).</p

Participants selection flow in the HALS.

<p>*These subjects with missing data for any of the following covariates: age, general health questionnaire, marital status, occupational social class, alcohol consumption, smoking status, height, weight and waist circumference.</p

Results of regression analyses of measures of atherosclerosis in the carotid and peripheral arteries in relation to intelligence in childhood.

<p>Results of regression analyses of measures of atherosclerosis in the carotid and peripheral arteries in relation to intelligence in childhood.</p

Heat map of associations between the polygenic profile scores for neurodegenerative disease and cognitive ability and physical health.

<p>Stronger associations are indicated by darker shades, red indicates a positive association, blue indicates a negative association. AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; FTD, frontotemporal dementia; TMT B-A, trail-making part B–part A; TMT B, trail making part B; TMT A, trail making part A; DSS, digit symbol substitution; VNR, verbal numerical reasoning; FVC, forced vital capacity; PEF, peak expiratory flow; FEV1, forced expiratory volume in 1s. *, significant association after FDR correction (p-value ≤ 0.018 (AD), 0.024 (ALS), or 0.0041 (FTD)). Full results can be found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0198187#pone.0198187.s001" target="_blank">S1 Table</a>.</p

Correlations between intelligence at age 11 years and measures of atherosclerosis at age 73.

<p>Correlations between intelligence at age 11 years and measures of atherosclerosis at age 73.</p

Cognitive and physical variable comparison between high Alzheimer’s disease (AD) polygenic risk, amyotrophic lateral sclerosis (ALS) polygenic risk, and frontotemporal dementia (FTD) polygenic risk, N for each group is shown.

<p>Cognitive and physical variable comparison between high Alzheimer’s disease (AD) polygenic risk, amyotrophic lateral sclerosis (ALS) polygenic risk, and frontotemporal dementia (FTD) polygenic risk, N for each group is shown.</p

Characteristics of the study participants (n = 713).

<p>*based on 654 people</p><p>^†based on 680 people</p><p>Characteristics of the study participants (n = 713).</p