FILIPINO TIKTOK INFLUENCERS AND PURCHASING BEHAVIOR OF YOUNG PROFESSIONALS

The traditional use of conventional media by businesses for audience targeting has shifted with the rise of influencer marketing, notably on platforms like TikTok, posing challenges in content adaptation and technological adaptation. Albert Bandura's Social Cognitive Theory examines factors shaping purchasing behavior, particularly relevant for young professionals. A quantitative correlational study focused on young professionals engaging with TikTok and influenced by Filipino TikTok creators, revealing education level as a key determinant of purchasing behavior. Extended TikTok engagement positively correlates with increased purchasing likelihood. Filipino TikTok influencers significantly impact young professionals' purchasing decisions, emphasizing the need for tailored marketing strategies targeting this demographic. Recommendations were provided for effective influencer and digital marketing strategies targeting young professionals

Automatic brake system (ABS).

There have been many safety features built for automobiles over the past years. Air bags, seatbelts and Antilock Braking System (ABS) are some examples them. But no one has yet created an Automatic Brake System. Only recently did developers tried to build such systems. Some prototypes have been developed but were not made available in the market. It may take a long period of time before this technology is perfected. Automatic Brake System would prove to be very useful in the world. This will help lessen the occurrence of car accidents. People, especially those, who spend most of their life on the road, would be aided by such system. Lesser chances of car crashes. Lesser events of hit and runs. Lesser people hit by car. Lesser deaths brought about by car accidents. These could also be of use to old people, crippled, people with eye problem, people with leg problems, drunks, and people not concentrating on the road while driving because reaction time for applying brakes would be faster than usual. the system could also be applied to other vehicles like trains and other land vehicles. Such system could be applied to other fields like autonomous robotic system and navigation. These will certainly pose a major breakthrough in technology. The proposed project intends to make this dream a reality. It may not totally eliminate car accidents but lessens the danger in the open road. The system may not also be fully functional but will be a stepping stone for future developers. This thesis document discusses the details of the study. The objective of this document is to provide information to those who are willing and interested to this kind of technology. It also aims to educate future developers of systems similar to technology discussed. Chapter 1, Introduction , informs readers on the background of study. How the study came to being and what is its connection to the current state of technology is also discussed. Objectives both general and specific, and the project\u27s scope and limitation are tackled in this chapter. Methodologies, the proponents followed in order to come up with the solutions to problems, are stated in this section of the document. Chapter 2, Related Theories , deals with the theoretical background that leads to the development and design of the proposed system. It is in the subtopics of this chapter that the theories are being discussed. Chapter 3, The System , the design of the system is discussed in this chapter. Block diagram of the system and subsystems is further explained in this section. The proposed system\u27s functions and applications are tackled in this chapter. Chapter 4, Performance Analysis , explains the experiments and tests made to prove the reliability and feasibility of the system. Chapter 5, Conclusion , summary of the first four chapter and the concluding remarks about the system is taken up in this chapter

Pharmacy to patient (P2P) drug monitoring: Inventory management system and app-enabled medication adherance monitoring system

The Pharmacy-to-Patient (P2P) drug monitoring : Inventory Management System and App-Enabled Medication Adherence Monitoring System consists of two studies, one to improve management of drug stocking in pharmacies, and another to develop a way to observe compliance to treatment regimens with increased reliability. Drug restocking will be based from data analysis of sales to increase the efficiency of drug flow in the inventory, thus, lessening overstocking of drugs. On medication adherence, a mobile application will be programmed to remind patients to drink their medicine in the right intervals as well as alert and send videos to DOTS representatives for proper checking. The study aims to ensure that the pharmacy will always have enough stock and show the trends of sales of the medicines. Information concluded by experts based on the graphs may lead to better service and improvement of healthcare of patients in the area. The medical adherence application\u27s goal is to allow the patients to take their DOTS medication anywhere. They no longer need to visit the DOTS centers just to drink the medicine. Doctors and health officers will also have less work in checking because they do not need to have set appointments to see the patients personally

Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo.

UnlabelledAdeno-associated virus 2 (AAV2) and adenovirus 5 (Ad5) are promising gene therapy vectors. Both display liver tropism and are currently thought to enter hepatocytes in vivo through cell surface heparan sulfate proteoglycans (HSPGs). To test directly this hypothesis, we created mice that lack Ext1, an enzyme required for heparan sulfate biosynthesis, in hepatocytes. Ext1(HEP) mutant mice exhibit an 8-fold reduction of heparan sulfate in primary hepatocytes and a 5-fold reduction of heparan sulfate in whole liver tissue. Conditional hepatocyte Ext1 gene deletion greatly reduced AAV2 liver transduction following intravenous injection. Ad5 transduction requires blood coagulation factor X (FX); FX binds to the Ad5 capsid hexon protein and bridges the virus to HSPGs on the cell surface. Ad5.FX transduction was abrogated in primary hepatocytes from Ext1(HEP) mice. However, in contrast to the case with AAV2, Ad5 transduction was not significantly reduced in the livers of Ext1(HEP) mice. FX remained essential for Ad5 transduction in vivo in Ext1(HEP) mice. We conclude that while AAV2 requires HSPGs for entry into mouse hepatocytes, HSPGs are dispensable for Ad5 hepatocyte transduction in vivo. This study reopens the question of how adenovirus enters cells in vivo.ImportanceOur understanding of how viruses enter cells, and how they can be used as therapeutic vectors to manage disease, begins with identification of the cell surface receptors to which viruses bind and which mediate viral entry. Both adeno-associated virus 2 and adenovirus 5 are currently thought to enter hepatocytes in vivo through heparan sulfate proteoglycans (HSPGs). However, direct evidence for these conclusions is lacking. Experiments presented herein, in which hepatic heparan sulfate synthesis was genetically abolished, demonstrated that HSPGs are not likely to function as hepatocyte Ad5 receptors in vivo. The data also demonstrate that HSPGs are required for hepatocyte transduction by AAV2. These results reopen the question of the identity of the Ad5 receptor in vivo and emphasize the necessity of demonstrating the nature of the receptor by genetic means, both for understanding Ad5 entry into cells in vivo and for optimization of Ad5 vectors as therapeutic agents

Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo

Adeno-associated virus 2 (AAV2) and adenovirus 5 (Ad5) are promising gene therapy vectors. Both display liver tropism and are currently thought to enter hepatocytes in vivo through cell surface heparan sulfate proteoglycans (HSPGs). To test directly this hypothesis, we created mice that lack Ext1, an enzyme required for heparan sulfate biosynthesis, in hepatocytes. Ext1(HEP) mutant mice exhibit an 8-fold reduction of heparan sulfate in primary hepatocytes and a 5-fold reduction of heparan sulfate in whole liver tissue. Conditional hepatocyte Ext1 gene deletion greatly reduced AAV2 liver transduction following intravenous injection. Ad5 transduction requires blood coagulation factor X (FX); FX binds to the Ad5 capsid hexon protein and bridges the virus to HSPGs on the cell surface. Ad5.FX transduction was abrogated in primary hepatocytes from Ext1(HEP) mice. However, in contrast to the case with AAV2, Ad5 transduction was not significantly reduced in the livers of Ext1(HEP) mice. FX remained essential for Ad5 transduction in vivo in Ext1(HEP) mice. We conclude that while AAV2 requires HSPGs for entry into mouse hepatocytes, HSPGs are dispensable for Ad5 hepatocyte transduction in vivo. This study reopens the question of how adenovirus enters cells in vivo. IMPORTANCE Our understanding of how viruses enter cells, and how they can be used as therapeutic vectors to manage disease, begins with identification of the cell surface receptors to which viruses bind and which mediate viral entry. Both adeno-associated virus 2 and adenovirus 5 are currently thought to enter hepatocytes in vivo through heparan sulfate proteoglycans (HSPGs). However, direct evidence for these conclusions is lacking. Experiments presented herein, in which hepatic heparan sulfate synthesis was genetically abolished, demonstrated that HSPGs are not likely to function as hepatocyte Ad5 receptors in vivo. The data also demonstrate that HSPGs are required for hepatocyte transduction by AAV2. These results reopen the question of the identity of the Ad5 receptor in vivo and emphasize the necessity of demonstrating the nature of the receptor by genetic means, both for understanding Ad5 entry into cells in vivo and for optimization of Ad5 vectors as therapeutic agents