TECHNICAL PROGRESS IN THE SETE TRAWL FISHERY, 1985-1999

Fisheries throughout the world have long been subject to overfishing and excess capacity, which has generated substantial and increasing concern about biological and economic performance ramifications. These problems in part stem from substantial investment in technical improvements to boats and equipment in fishing fleets. Such technical change exacerbates the extent of excess fishing capacity, as well as low returns to fishing effort and investment due to catch limitations from both regulatory constraints and overfished stocks. However, economists have not yet attempted to quantify the extent or effects of technical change in fisheries. In this paper we use detailed data on innovation patterns for 19 vessels in the Sete trawl fleet of Southern France to evaluate the contributions of embodied and disembodied technical change to catch rates. We find that embodied technical change enhanced productivity by approximately 1 percent per year between 1985-99, but that external (disembodied) events counteracted this by causing a net output decline of about 3 percent per year. Neither efficiency nor output composition changes appear to have had a substantive effect on observed performance levels.Research and Development/Tech Change/Emerging Technologies, Resource /Energy Economics and Policy,

Stapleless Laparoscopic Sleeve Gastrectomy : Reasoning and Technical Insights

Open access via Springer Compact AgreementPeer reviewedPublisher PD

Advanced multi-targeted composite biomaterial dressing for pain and infection control in chronic leg ulcers

This study aimed to develop advanced biomaterial polysaccharide based dressings to manage pain associated with infected chronic leg ulcers in older adults. Composite carrageenan (CARR) and hyaluronic acid (HA) dressings loaded with lidocaine (LID) and AgNPs were formulated as freeze-dried wafers and functionally characterized for porous microstructure (morphology), mechanical strength, moisture handling properties, swelling, adhesion and lidocaine release. Antimicrobial activity of AgNPs was evaluated (turbidity assay) against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus whilst cell viability studies (MTT) was performed on normal adult human primary epidermal keratinocyte cells. The wafers were soft, flexible and elegant in appearance. HA affected the wafer structure by increasing the resistance to compression but still possessed a balance between toughness and flexibility to withstand normal stresses and prevent damage to newly formed skin tissue respectively. Water uptake was influenced by HA, whilst equilibrium water content and LID release were similar for all the formulations, showing controlled release up to 6 h. AgNPs loaded CARR/HA wafers were effective in inhibiting the growth of both Gram positive and Gram negative bacteria. MTT assay showed evidence that the AgNPs/ LID loaded wafers did not interfere with cell viability and growth. CARR/HA wafers seem to be a promising system to simultaneously deliver LID and AgNPs, directly to infected chronic leg ulcers

Development of advanced analgesic dressings for chronic wound healing

Background: Pain is a ubiquitous problem in patients with chronic leg wounds. Recent studies have reported that 17 - 65% of patients experience severe or continuous pain that, associated with other characteristics of chronic ulcers such as odour, have debilitating effects on the patients including both their mental and psychological wellbeing. The aim of this work is to develop advanced wound dressings for local delivery of an analgesic drug that can help to manage pain associated with chronic leg ulcers in older adults. The addition of hyaluronic acid (HA) in the composition added beneficial and well recognized HA properties in the wound healing process. Methods: Advanced dressings loaded with an analgesic drug (lidocaine) were formulated as lyophilised xerogels (wafers) by freeze-drying. Different HA ratios by weight were used to improve the wafer characteristics. The dressings were tested for functional characteristics including mechanical strength, porous microstructure, stability, polymorphic/amorphous transitions, hydration, swelling and in vitro mucoadhesion. An HPLC method was developed to assess lidocaine release from wafers. Results: On the basis of feasibility study of the use of analgesic dressings in older adults with leg ulcers, an advanced dressing loaded with lidocaine was formulated. Wafers, due to their porous nature, have proved to be suitable for medium to high exuding wounds (common in leg ulcers), whilst still maintaining their physical integrity. Both blank and drug-loaded wafers were soft, flexible, elegant in appearance and non-brittle in nature. The addition of HA had an influence on wafer structure changing their properties, but mechanical characterisation demonstrated that the wafers were strong enough to withstand normal stresses but also flexible to prevent damage to newly formed skin tissue. The lidocaine release from the optimised dressing showed continuous release for over 12 h. Conclusions: Wafer seems to be a very promising system for delivery of analgesic drug to the wound. Further studies are in progress to evaluate in vitro activity of the dressings and role of HA in the wound healing process

3D-printed scaffold composites for the stimuli-induced local delivery of bioactive adjuncts

Polysaccharide scaffolds have been successfully employed to reconstruct environments that sustain skin tissue regeneration after injuries. Three-dimensional (3D) advanced additive manufacturing technologies allow creating scaffolds with controlled and reproducible macro- and micro-structure that improve the quality of the restored tissue to favor spontaneous repair. However, when persistent inflammation occurs, the physiological tissue healing capacity is reduced, like in the presence of pathologies like diabetes, vascular diseases, chronic infection, and others. In these circumstances, the bioavailability of therapeutic adjuncts like the growth factors in addition to the standard treatments represents undoubtedly a promising strategy to accelerate the healing of skin lesions. Precisely designed polysaccharide scaffolds obtained by 3D printing represent a robust platform that can be further implemented with the controlled delivery of bioactive adjuncts. Human elastin-like polypeptides (HELPs) are stimuli-responsive biopolymers. Their structure allows the integration of domains endowed with biological functionality, making them attractive compounds to prepare composites with smart properties. In the present study, 3D-printed alginate and chitosan scaffolds were combined with the HELP components. The HELP biopolymer was fused to the epidermal growth factor (EGF) as the bioactive domain. Different constructs were prepared and the stimuli-responsive behavior as well as the biological activity were evaluated, suggesting that these smart bioactive composites are suitable to realize multifunctional dressings that sustain the local release of therapeutic adjuncts

Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application

In this contribution we describe the preparation and characterization of a series of cross-linked films based on the combination of an elastin-derived biomimetic polypeptide (Human elastin-like polypeptide (HELP)) with alginate (ALG) to obtain a composite with enhanced properties. ALG/HELP composite films loaded with the hydrophobic natural antioxidant curcumin were prepared by solvent casting method followed by the cross-linking with calcium chloride. The compatibility between the two components as well as the final properties was evaluated. The micro-morphological study of films showed a homogeneous structure, but the film tensile strength decrease with HELP content and elongation at break was adversely affected by biopolymer addition. Spectroscopic and thermal analyses confirmed an interaction between ALG and HELP which also causes a modification in swelling kinetics and faster degradation. Moreover, the study of curcumin release showed a controlled delivery up to 10\u202fdays with a faster release rate in the presence of HELP. Human Dermal Fibroblasts (hDF) were used to test the in vitro cytocompatibility. The antioxidant activity correlated to the increase of HELP content suggested the applicability of these composites to develop smart biomaterials. Overall, these features indicated how this composite material has considerable potential as customizable platforms for various biomedical applications

Applying an Established Exposure Response Prevention Protocol for Young People With Tourette Syndrome in an Intensive, Group Format: A Feasibility Study

Background: The motor and vocal tics that characterise Tourette syndrome are stigmatizing and impact on quality of life. Behavioural interventions such as Exposure Response Prevention or Comprehensive Behavioural Interventions for Tics are first line treatment for Tourette syndrome, but availability is limited. This study is the first to explore the impact of an established manualised Exposure Response Prevention treatment protocol, developed for individual therapy, but here uniquely delivered intensively, to a group. // Methods: A naturalistic study comprised of a consecutive series of children (N = 20), aged 8–16 years (M = 12, SD = 2.17) were offered Exposure Response Prevention in one of two groups, delivered in series within a specialist clinic. Young people received the equivalent of 12 sessions (matching the manualised individual protocol). // Results: The YGTSS and Giles de la Tourette Syndrome Quality of Life Scale for Children and Adolescents (Satisfaction Scale) showed significant improvement following treatment with moderate to large effect sizes. Thirty-five percent of children demonstrated a reliable improvement on the YGTSS Global Tic Severity score. // Conclusions: These data suggest an established Exposure Response Prevention protocol can be delivered in an intensive, group setting with a positive clinical outcome. Replication in a randomized controlled trial is an important next step

Fishery Management in the Mediterranean: An Evaluation of French Effort-based Management Systems

The international institutional context for fishery management in the Mediterranean is changing due to the evolution of the General Fisheries Commission for the Mediterranean and the review of the Common Fisheries Policy due in 2002. This changing context offers an ideal opportunity to re-consider the fundamental fishery management strategy. It is widely proposed that only an effort-based management system can succeed in the Mediterranean. Yet in the fishery management literature and in practice in other fisheries around the world, it seems increasingly accepted that effort-based systems suffer significant drawbacks compared to other kinds of system. This paper evaluates the limits and advantages of an effort-based system given the particular nature of Mediterranean fisheries.Keywords: Mediterranean, fishing effort, management, Franc

Cost-effectiveness of a mental health drop-in center for young people with long-term physical conditions

BACKGROUND: Paediatric patients being treated for long-term physical health conditions (LTCs) have elevated mental health needs. However, mental health services in the community are difficult to access in the usual course of care for these patients. The Lucy Project – a self-referral drop-in access point—was a program to address this gap by enrolling patients for low-intensity psychological interventions during their treatment for LTCs. In this paper, we evaluate the cost-effectiveness of the Lucy Project. METHODS: Using a pre-post design, we evaluate the cost-effectiveness of the intervention by calculating the base-case incremental cost-effectiveness ratio (ICER) using outcomes data and expenses recorded by project staff. The target population was paediatric patients enrolled in the program with an average age of 9 years, treated over a time horizon of 6 months. Outcome data were collected via the Paediatric Quality of Life Inventory, which was converted to health utility scores using an instrument found in the literature. The QALYs were estimated using these health utility scores and the length of the intervention. We calculate a second, practical-case incremental cost-effectiveness ratio using streamlined costing figures with maximum capacity patient enrolment within a one-year time horizon, and capturing lessons learned post-trial. RESULTS: The base-case model showed an ICER of £21,220/Quality Adjusted Life Years (QALY) gained, while the practical model showed an ICER of £4,359/QALY gained. The practical model suggests the intervention garners significant gains in quality of life at an average cost of £309 per patient. Sensitivity analyses reveal use of staff time was the greatest determinant of the ICER, and the intervention is cost-effective 75% of the time in the base-case model, and 94% of the time in the practical-case model at a cost-effectiveness threshold of £20,000/QALY gained. CONCLUSIONS: We find the base-case intervention improves patient outcomes and can be considered cost-effective according to the National Institute for Health and Care Excellence (NICE) threshold of £20,000—£30,000/QALY gained, and the practical-case intervention is roughly four times as cost-effective as the base-case. We recommend future studies incorporate a control group to corroborate the effect size of the intervention