New Completeness Methods for Estimating Exoplanet Discoveries by Direct Detection

We report new methods for evaluating realistic observing programs that search stars for planets by direct imaging, where observations are selected from an optimized star list, and where stars can be observed multiple times. We show how these methods bring critical insight into the design of the mission & its instruments. These methods provide an estimate of the outcome of the observing program: the probability distribution of discoveries (detection and/or characterization), & an estimate of the occurrence rate of planets (eta). We show that these parameters can be accurately estimated from a single mission simulation, without the need for a complete Monte Carlo mission simulation, & we prove the accuracy of this new approach. Our methods provide the tools to define a mission for a particular science goal, for example defined by the expected number of discoveries and its confidence level. We detail how an optimized star list can be built & how successive observations can be selected. Our approach also provides other critical mission attributes, such as the number of stars expected to be searched, & the probability of zero discoveries. Because these attributes depend strongly on the mission scale, our methods are directly applicable to the design of such future missions & provide guidance to the mission & instrument design based on scientific performance. We illustrate our new methods with practical calculations & exploratory design reference missions for JWST operating with a distant starshade to reduce scattered and diffracted starlight on the focal plane. We estimate that 5 habitable Earth-mass planets would be discovered & characterized with spectroscopy, with a probability of 0 discoveries of 0.004, assuming a small fraction of JWST observing time (7%), eta=0.3, and 70 observing visits, limited by starshade fuel.Comment: 27 pages, 4 figures, 6 tables, accepted for publication by Ap

Postsynaptic Elevation of Calcium Induces Persistent Depression of Developing Neuromuscular Synapses

AbstractSynaptic activity is known to modulate neuronal connectivity in the nervous system. At developing Xenopus neuromuscular synapses in culture, repetitive postsynaptic application of ACh near the synapse leads to immediate and persistent synaptic depression, which was shown to be caused by reduction of presyaptic evoked transmitter release. However, little depression was found when ACh was applied to the muscle 20 μm or further from the synapse. Fluorescence imaging of cytosolic Ca2+ ([Ca2+]i) showed that each ACh pulse induced a transient elevation of myocyte [Ca2+]i that spread approximately 20 μm. Local photoactivated release of Ca2+ from the caged Ca2+ chelators nitr-5 or nitrophen in the postsynaptic cell was sufficient to induce persistent synaptic depression. These results support a model in which localized Ca2+ influx into the postsynaptic myocyte initiates transsynaptic retrograde modulation of presynaptic secretion mechanisms

Compatibility studies of several molten uranium and thorium alloys in niobium, tantalum, and yttrium

Niobium, tantalum, yttrium, and Inconel have been used to contain molten aluminum, lead, tin, zinc, and several of their respective uranium and thorium alloys for various times up to 3000 hours and at temperatures ranging from 600 to 1100° C. Altogether 76 capsule tests were run, almost all in a static isothermal condition. Tantalum showed the best resistance followed by niobium, Inconel, and yttrium respectively. The systems, lead in tantalum and lead in niobium, showed the greatest potentials for possible liquid-metal fuel carrier systems. An alloy of uranium-bismuth-tin contained in tantalum also exhibited promising possibilities . The tabulated test data include a classification of the type of corrosion attack which occurred and a measured value of the amount of corrosive penetration. Each test was also given an arbitrary rating for easy reference comparisons. A number of photomicrographs are included for each set of tests

Groundbreaking Regional Water Planning in Georgia: Lessons from the Middle Chattahoochee, Upper Flint and Lower Flint Ochlockonee Regional Water Councils

2012 S.C. Water Resources Conference - Exploring Opportunities for Collaborative Water Research, Policy and Managemen