National and Regional Estimates of the Prevalence of Opiate and/or Crack Cocaine use 2008-09: A summary of key findings

<p>This report summarises the results of a follow-up study to a three year project to estimate the prevalence of ‘problem drug use’ (defined as use of opiates and/or crack cocaine) nationally (England only), regionally and locally. The follow-up was carried out two years after the final sweep of the original project, so could therefore be considered as ‘sweep 5’. An overview of the national and regional estimates are presented in this report, as are comparisons with the estimates produced by the third (2006-07) sweep of the study. Estimates for 2007-08 are not available as a study was not commissioned for that year.</p> <p>Information about the number of people who use illicit drugs such as heroin, other opiates or crack cocaine is key to formulating effective policies for tackling drug-related harm as these drugs are associated with the highest levels of harm. It also helps inform service provision at the local level and provides a context in which to understand the population impact of interventions to reduce drug-related harm.</p> <p>Direct enumeration of those engaged in a largely covert activity such as the use of class A drugs is difficult and standard household survey techniques tend to underestimate the extent of such activity. Indirect techniques making use of various data sources offer a more reliable way of calculating prevalence estimates for the use of opiates and/or crack cocaine. The estimates presented in this report are derived using two indirect measurement techniques: the capture-recapture method (CRC ); and the multiple indicator (MIM ) method. These methods are described in detail in Hay et al., 2006 and Hay et al., 2007a. Methodological developments throughout the course of the previous three sweeps are discussed elsewhere (Hay et al., 2007b, Hay et al., 2008). The individuals covered by this study were people aged 15 to 64 and resident in each DAT area, and known to be using heroin, methadone, other opiate drugs or crack cocaine.</p&gt

A Dual Read-Out Assay to Evaluate the Potency of Compounds Active against Mycobacterium tuberculosis

PMCID: PMC3617142This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Searching for Star Formation Beyond Reionization

The goal of searching back in cosmic time to find star formation during the epoch of reionization will soon be within reach. We assess the detectability of high-redshift galaxies by combining cosmological hydrodynamic simulations of galaxy formation, stellar evolution models appropriate for the first generations of stars, and estimates of the efficiency for Lyman alpha to escape from forming galaxies into the intergalactic medium. Our simulated observations show that Lyman alpha emission at z ~ 8 may be observable in the near-infrared with 8-meter class telescopes and present-day technology. Not only is the detection of early star-forming objects vital to understanding the underlying cause of the reionization of the universe, but the timely discovery of a z > 7 star-forming population -- or even an interesting upper limit on the emergent flux from these objects -- will have implications for the design of the next generation of ground- and space-based facilities.Comment: 4 pages, submitted to ApJ Letter

Constraint algebra in LQG reloaded : Toy model of a U(1)^{3} Gauge Theory I

We analyze the issue of anomaly-free representations of the constraint algebra in Loop Quantum Gravity (LQG) in the context of a diffeomorphism-invariant gauge theory in three spacetime dimensions. We construct a Hamiltonian constraint operator whose commutator matches with a quantization of the classical Poisson bracket involving structure functions. Our quantization scheme is based on a geometric interpretation of the Hamiltonian constraint as a generator of phase space-dependent diffeomorphisms. The resulting Hamiltonian constraint at finite triangulation has a conceptual similarity with the "mu-bar"-scheme in loop quantum cosmology and highly intricate action on the spin-network states of the theory. We construct a subspace of non-normalizable states (distributions) on which the continuum Hamiltonian constraint is defined which leads to an anomaly-free representation of the Poisson bracket of two Hamiltonian constraints in loop quantized framework.Comment: 60 pages, 6 figure

Medical symptoms associated with tobacco smoking with and without marijuana abuse among crack cocaine-dependent patients.

Despite the widespread use of tobacco and marijuana by cocaine abusers, it remains unclear whether combined tobacco and marijuana smoking is more harmful than tobacco smoking alone in cocaine abusers. We investigated the differences in medical symptoms reported among 34 crack cocaine abusers who did not smoke tobacco or marijuana (C), 86 crack cocaine abusers who also smoked tobacco (C + T), and 48 crack abusers who smoked both tobacco and marijuana (C + T + M). Medical symptoms were recorded using a 134-item self-report instrument (MILCOM), and drug use was assessed using the Addiction Severity Index (ASI). After controlling for clinical and demographic differences, the C + T + M group reported significantly more total symptoms on the MILCOM as well as on the respiratory, digestive, general, and nose/throat subscales than the C + T or C groups. The C + T group reported higher total and respiratory and nose/throat symptoms than the C group. HOwever, the C group had the highest number of mood symptoms among the three groups. The C + T and C + T + M groups were comparable in number of cigarettes smoked and ASI scores. Although tobacco smoking is associated with higher reports of medical problems in crack abusers, smoking both marijuana and tobacco seems to be associated with greater medical problems than smoking tobacco alone. Tobacco smoking was not related to changes in cocaine use. Also, marijuana smoking does not appear to be associated with a reduction in tobacco or cocaine use

Information Technology Usage In Accounting Firms: The Best Versus The Rest

The purpose of this paper is to analyze information technology expenditures in public accounting firms from a multi-year sample.  This study also focuses on identifying possible IT spending trends in public accounting firms and attempts to determine if additional spending on IT increased the profitability of these firms