Cosmic Gravitational Shear from the HST Medium Deep Survey

We present a measurement of cosmic shear on scales ranging from 10\arcsec to 2\arcmin in 347 WFPC2 images of random fields. Our result is based on shapes measured via image fitting and on a simple statistical technique; careful calibration of each step allows us to quantify our systematic uncertainties and to measure the cosmic shear down to very small angular scales. The WFPC2 images provide a robust measurement of the cosmic shear signal decreasing from $5.2$ at 10\arcsec to $2.2$ at 130\arcsec .Comment: 4 pages 2 Postscript figures, uses emulateapj.cls Astrophysical Journal Letters, December 1, 200

Optical Identification of Cepheids in 19 Host Galaxies of Type Ia Supernovae and NGC 4258 with the Hubble Space Telescope

We present results of an optical search for Cepheid variable stars using the Hubble Space Telescope (HST) in 19 hosts of Type Ia supernovae (SNe Ia) and the maser-host galaxy NGC 4258, conducted as part of the SH0ES project (Supernovae and H0 for the Equation of State of dark energy). The targets include 9 newly imaged SN Ia hosts using a novel strategy based on a long-pass filter that minimizes the number of HST orbits required to detect and accurately determine Cepheid properties. We carried out a homogeneous reduction and analysis of all observations, including new universal variability searches in all SN Ia hosts, that yielded a total of 2200 variables with well-defined selection criteria -- the largest such sample identified outside the Local Group. These objects are used in a companion paper to determine the local value of H0 with a total uncertainty of 2.4%.Comment: ApJ, in press. v2 adds missing co-author to arXiv metadata and text in acknowledgment

A New H I Survey of Active Galaxies

We have conducted a new Arecibo survey for H I emission for 113 galaxies with broad-line (type 1) active galactic nuclei (AGNs) out to recession velocities as high as 35,000 km/s. The primary aim of the study is to obtain sensitive H I spectra for a well-defined, uniformly selected sample of active galaxies that have estimates of their black hole masses in order to investigate correlations between H I properties and the characteristics of the AGNs. H I emission was detected in 66 out of the 101 (65%) objects with spectra uncorrupted by radio frequency interference, among which 45 (68%) have line profiles with adequate signal-to-noise ratio and sufficiently reliable inclination corrections to yield robust deprojected rotational velocities. This paper presents the basic survey products, including an atlas of H I spectra, measurements of H I flux, line width, profile asymmetry, optical images, optical spectroscopic parameters, as well as a summary of a number of derived properties pertaining to the host galaxies. To enlarge our primary sample, we also assemble all previously published H I measurements of type 1 AGNs for which can can estimate black hole masses, which total an additional 53 objects. The final comprehensive compilation of 154 broad-line active galaxies, by far the largest sample ever studied, forms the basis of our companion paper, which uses the H I database to explore a number of properties of the AGN host galaxies.Comment: To appear in ApJS; 31 pages. Preprint will full-resolution figures can be downloaded from http://www.ociw.edu/~lho/preprints/ms1.pd

Molecular hydrogen beyond the optical edge of an isolated spiral galaxy

We know little about the outermost portions of galaxies because there is little light coming from them. We do know that in many cases atomic hydrogen (HI) extends well beyond the optical radius \cite{Casertano91}. In the centers of galaxies, however, molecular hydrogen (H2) usually dominates by a large factor, raising the question of whether H2 is abundant also in the outer regions but hitherto unseen.Here we report the detection of emission from carbon monoxide (CO), the most abundant tracer of H2, beyond the optical radius of the nearby galaxy NGC 4414. The molecular clouds probably formed in the regions of relatively high HI column density and in the absence of spiral density waves. The relative strength of the lines from the two lowest rotational levels indicates that both the temperature and density of the H2 are quite low compared to conditions closer to the center. The inferred surface density of the molecular material continues the monotonic decrease from the inner regions. We conclude that while molecular clouds can form in the outer region of this galaxy, there is little mass associated with them.Comment: 3 Nature page

HST Measurements of the Expansion of NGC 6543: Parallax Distance and Nebular Evolution

The optical expansion parallax of NGC 6543 has been detected and measured using two epochs of HST images separated by a time baseline of only three years. We have utilized three separate methods of deriving the angular expansion of bright fiducials, the results of which are in excellent agreement. We combine our angular expansion estimates with spectroscopically obtained expansion velocities to derive a distance to NGC 6543 of 1001$\pm$269 pc. The deduced kinematic age of the inner bright core of the nebula is 1039$\pm$259 years; however, the kinematic age of the polar caps that surround the core is larger - perhaps the result of deceleration or earlier mass ejection. The morphology and expansion patterns of NGC 6543 provide insight into a complex history of axisymmetric, interacting stellar mass ejections.Comment: Accepted for publication in AJ. 18 pages. 6 figure

Extinction Curves, Distances, and Clumpiness of Diffuse Interstellar Dust Clouds

We present CCD photometry in UBVRI of several thousand Galactic field stars in four large (>1 degree^2) regions centered on diffuse interstellar dust clouds, commonly referred to as ``cirrus'' clouds (with optical depth A_V less than unity). Our goal in studying these stars is to investigate the properties of the cirrus clouds. A comparison of the observed stellar surface density between on-cloud and off-cloud regions as a function of apparent magnitude in each of the five bands effectively yields a measure of the extinction through each cloud. For two of the cirrus clouds, this method is used to derive UBVRI star counts-based extinction curves, and U-band counts are used to place constraints on the cloud distance. The color distribution of stars and their location in (U-B, B-V) and (B-V, V-I) color-color space are analyzed in order to determine the amount of selective extinction (reddening) caused by the cirrus. The color excesses, A_lambda-A_V, derived from stellar color histogram offsets for the four clouds, are better fit by a reddening law that rises steeply towards short wavelengths [R_V==A_V/E(B-V)<=2] than by the standard law (R_V=3.1). This may be indicative of a higher-than-average abundance of small dust grains relative to larger grains in diffuse cirrus clouds. The shape of the counts-based effective extinction curve and a comparison of different estimates of the dust optical depth (extinction optical depth derived from background star counts/colors; emission optical depth derived from far infrared measurements), are used to measure the degree of clumpiness in clouds. The set of techniques explored in this paper can be readily adapted to the Sloan Digital Sky Survey data set in order to carry out a systematic, large-scale study of cirrus clouds.Comment: 22 pages, 13 figures (postscript, gif, jpg). Accepted for publication in the Astronomical Journal, scheduled for the May 1999 issue. Full resolution postscript versions of all figures are available at http://www.ucolick.org/~arpad

Dual targeting of ptp1b and aldose reductase with marine drug phosphoeleganin: A promising strategy for treatment of type 2 diabetes

An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AR) enzymes, including analysis of the insulin signalling pathway, of phosphoeleganin, a marine-derived phosphorylated polyketide, was achieved. Phosphoeleganin was demonstrated to inhibit both enzymes, acting respectively as a pure non-competitive inhibitor of PTP1B and a mixed-type inhibitor of AR. In addition, in silico docking analyses to evaluate the interaction mode of phosphoeleganin with both enzymes were performed. Interestingly, this study showed that phosphoeleganin is the first example of a dual inhibitor polyketide extracted from a marine invertebrate, and it could be used as a versatile scaffold structure for the synthesis of new designed multiple ligands