72 research outputs found

    Fort Berthold Dam Site v. The Garrison Dam Site Statement of Fact and Law. Amended and Extended, 1947

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    Statement of Fact concerning the Fort Berthold site v. The Garrison Dam site presented by the Indian People of Fort Berthold Reservation, North Dakota that has been extended and amended. Headers include: Impending losses of Indian lands, Impending Danger Garrison Dam Site of Opinions of Army and Other Engineers for the inadequacy of the site foundation, Discussion, The unnecessity of Garrison Dam, The Alternate Offer of the Fort Berthold Dam site, The prohibition from Congrees for use of money to construct the dam, The War Department offer of Lieu Lands, Interior Department Declination of War Department Offer, Losses Sustained by Construction of Garrison Dam, Losses to North Dakota, Losses to the United States, Losses to the Indians of Fort Berthold Reservation, North Dakota, and The Remedy. See also: Fort Berthold Dam Site v. The Garrison Dam Site Statement of Fact and Law.https://commons.und.edu/langer-papers/1148/thumbnail.jp

    Outline of Contract, The United States of America with the Three Affiliated Tribes of Fort Berthold Reservation, September, 1947

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    This document, undated but determined to have been prepared in September, 1947, by Ralph H. Case, General Counsel for the Three Affiliated Tribes of the Fort Berthold Reservation, North Dakota, outlines the provisions of a contract between the United States of America and the Three Affiliated Tribes by which the Tribes would exchange title for a section of the Fort Berthold Reservation in exchange for $5,105,625 in order to make way for a dam and reservoir on the Missouri River. The provisions include definitions of terms and physical boundaries of the taking area, mechanisms for reappraisal, details regarding where funds will reside and rate of interest, settlement of estates, disbursement of shares, period of occupation before inundation, rights to salvage, relocation and housing of residents, rights to timber, lignite, sand, gravel, and future subsurface discoveries, disinterment and re-interment of ancestors, use of shorelands, hunting and fishing rights, operation of harbors, supplying of electrical light and power, irrigation, agency structures including schools hospitals, roads, bridges and ferries, operation of the dam and reservoir, and rules regarding ratification, post-ratification acceptance and re-ratification, if necessary, of the contract, and the transferring of title. While this document is not dated, based on references in related documents it has been determined to have been prepared in September of 1947. See also: Letter from Ralph H. Case to Senator Langer Regarding Questionnaire Regarding Creation of Contract to Receive Compensation in Return for Land Taken for the Garrison Dam Project, October 3, 1947 An Act to Vest Title to Certain Lands of the Three Affiliated Tribes of the Fort Berthold Reservation, North Dakota, in the United States, and to Provide Compensation Thereforhttps://commons.und.edu/langer-papers/1997/thumbnail.jp

    Letter from Ralph H. Case to Senator Langer Regarding Questionnaire Regarding Creation of Contract to Receive Compensation in Return for Land Taken for the Garrison Dam Project, October 3, 1947

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    This letter dated October 3, 1947, from Ralph H. Case, general counsel for the Three Affiliated Tribes of the Fort Berthold Reservation to United States (US) Senator William Langer, Case makes reference to a new draft he is enclosing of a questionnaire he has revised by adding an amendment suggested by Langer and thanks Langer for his careful study of the questionnaire, his very valuable suggestion, and his words of commendation, adding that it is indeed a difficult task to explain all things to all men. The enclosed questionnaire covers cover such things as the reader\u27s awareness that the Garrison Dam will be built, what its effects will be, what the US Government is proposing as compensation, what the Tribes\u27 response should be, and whether the Tribal Council and the tribes\u27 attorney should be authorized to write a counteroffer in the form of a contract to be approved or disapproved by members by vote. Other questions deal with whether the reader owns land in the taking area, the reader\u27s preference for a monetary settlement or land to replace the tribal lands to be inundated, what accommodations should be made for landless tribal members, and how income from timber and lignite should be treated. The questionnaire also gives information on provisions likely to be included in the proposed contract, including the construction of new homes, supplying of electricity and water for irrigation, oil and gas rights, the construction of new roads and operation of ferries to cross the reservoir, and a variety of other matters. See also: Questionnaire Regarding Creation of Contract to Receive Compensation in Return for Land Taken for the Garrison Dam Project, October 1947 Outline of Contract, The United States of America with the Three Affiliated Tribes of Fort Berthold Reservation, September, 1947https://commons.und.edu/langer-papers/2000/thumbnail.jp

    Letter from Ralph H. Case to Ben Reifel Regarding Questionnaire Regarding Creation of Contract to Receive Compensation in Return for Land Taken for the Garrison Dam Project, October 3, 1947

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    This letter, dated October 3, 1947, from Ralph H. Case, general counsel for the Three Affiliated Tribes of the Fort Berthold Reservation, North Dakota, to Ben Reifel, Superintendent of the Fort Berthold Indian Agency, makes reference to a letter Case sent the previous day to Reifel. Case explains that since that letter was sent, he has met with United States (US) Senator William Langer for an hour about the questionnaire Case has been working on regarding tribal members\u27 willingness to formulate a contract dictating the terms of their compensation for lands taken from them by the US government for the Garrison Dam and accompanying reservoir, and about the outline of the proposed contract. Case writes that Langer agrees to give the matter his full support. Case goes on to explain that, in going over the questionnaire, Langer pointed out a section where the wording was potentially misleading, so Case therefore amended the questionnaire to address Langer\u27s concern, and has enclosed with this letter the new paragraph to be amended to the questionnaire. Case also references a voucher for reimbursement he has enclosed regarding payment to an engineer employed by the Three Affiliated Tribes, which he asks Reifel to present to the Tribal Council, along with a resolution of approval, at their next meeting on October 9, and then to mail the resolution and voucher to Case, so that he can present it to the Indian Office for payment. The voucher for reimbursement Case mentions was not found with this letter in the Langer papers. See also: Questionnaire Regarding Creation of Contract to Receive Compensation in Return for Land Taken for the Garrison Dam Project, October 1947 Outline of Contract, The United States of America with the Three Affiliated Tribes of Fort Berthold Reservation, September, 1947https://commons.und.edu/langer-papers/2002/thumbnail.jp

    Fort Berthold Dam Site v. The Garrison Dam Site Statement of Fact and Law, 1947

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    Statement of Fact concerning the Fort Berthold Dam site v. the Garrison Dam site presented by The Indian People of Fort Berthold Reservation, North Dakota. The statement concerns Congress\u27s authorization for the construction of five dams on the Missouri river across North Dakota and South Dakota. The statement headlines involve: impending losses, alternate offers of plans and dam locations, prohibition of money for the Garrison Dam construction according to section 6 of the act of May 2, 1946, War Department offer of lieu lands, losses sustained to North Dakota and to the United States, and a remedy. The War Departments decline of offer letter sent by J.A. Kava, Secretary of the Interior, is included. The statement is a gathering of facts and argument presented by Fort Berthold Reservation to the opposition of the Garrison Dam construction. See also: Fort Berthold Dam Site v. The Garrison Dam Site Statement of Fact and Law. Amended and Extendedhttps://commons.und.edu/langer-papers/1143/thumbnail.jp

    Phase II study of fosaprepitant + 5HT3 receptor antagonist + dexamethasone in patients with germ cell tumors undergoing 5-day cisplatin-based chemotherapy: A Hoosier Cancer Research Network Study

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    Purpose A phase III study adding aprepitant to a 5HT3 receptor antagonist (5HT3-RA) plus dexamethasone in germ cell tumor (GCT) patients treated with 5-day cisplatin combination chemotherapy demonstrated a significant improvement in complete response (CR) (J Clin Onc 30:3998-4003, 2012). Fosaprepitant has demonstrated non-inferiority compared to aprepitant in single-day cisplatin chemotherapy and is approved as a single-dose alternative. This single-arm phase II study is the first clinical trial evaluating fosaprepitant in patients receiving multi-day cisplatin regimen. Methods GCT patients receiving a 5-day cisplatin combination chemotherapy were enrolled. Fosaprepitant 150 mg was given IV on days 3 and 5. A 5HT3-RA days 1–5 (days 1, 3, and 5, if palonosetron) plus dexamethasone 20 mg days 1 and 2 and 4 mg po bid days 6, 7, and 8 was administered. Rescue antiemetics were allowed. The primary objective was to determine the CR rate—no emetic episodes or use of rescue medications. Accrual of 64 patients was planned with expected CR > 27 %. Results Sixty-five patients were enrolled of whom 54 were eligible for analysis. Median age was 33. Fifty-one patients received bleomycin, etoposide, and cisplatin (BEP) chemotherapy. CR was observed in 13 (24.1 %) patients (95 % Agresti-Coull binomial C.I. 14.5 %, 37.1 %). Conclusion The data in this phase II study, in contrast to our prior phase III study, appears to indicate a lower CR rate with the substitution of fosaprepitant for aprepitant. It is unknown whether the substitution of fosaprepitant for aprepitant provides the same benefit in multi-day cisplatin that was achieved with single-day cisplatin

    Report of Second Meeting for the Purpose of Obtaining the Views of the Three Affiliated Tribes of the Fort Berthold Reservation on the Lieu Lands Offered by the Secretary of War, 1946

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    Report of the second meeting held in the office of Assistant Secretary of the Interior C. Girard Davidson for the purpose of obtaining the views of the Three Affiliated Tribes of the Fort Berthold Reservation of the lieu lands offered by the Secretary of War. Includes a list of attendees and a transcript of the meeting discussing the Three Affiliated Tribes\u27 rejection of the offer of lieu lands made by the Secretary of Interior and Department of War to the Fort Berthold Reservation. See also: Report of Meeting for the Purpose of Obtaining the Views of the Three Affiliated Tribes of the Fort Berthold Reservation on the Lieu Lands Offered by the Secretary of War, 1946https://commons.und.edu/langer-papers/1147/thumbnail.jp

    Type IV Secretion-Dependent Activation of Host MAP Kinases Induces an Increased Proinflammatory Cytokine Response to Legionella pneumophila

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    The immune system must discriminate between pathogenic and nonpathogenic microbes in order to initiate an appropriate response. Toll-like receptors (TLRs) detect microbial components common to both pathogenic and nonpathogenic bacteria, whereas Nod-like receptors (NLRs) sense microbial components introduced into the host cytosol by the specialized secretion systems or pore-forming toxins of bacterial pathogens. The host signaling pathways that respond to bacterial secretion systems remain poorly understood. Infection with the pathogen Legionella pneumophila, which utilizes a type IV secretion system (T4SS), induced an increased proinflammatory cytokine response compared to avirulent bacteria in which the T4SS was inactivated. This enhanced response involved NF-κB activation by TLR signaling as well as Nod1 and Nod2 detection of type IV secretion. Furthermore, a TLR- and RIP2-independent pathway leading to p38 and SAPK/JNK MAPK activation was found to play an equally important role in the host response to virulent L. pneumophila. Activation of this MAPK pathway was T4SS-dependent and coordinated with TLR signaling to mount a robust proinflammatory cytokine response to virulent L. pneumophila. These findings define a previously uncharacterized host response to bacterial type IV secretion that activates MAPK signaling and demonstrate that coincident detection of multiple bacterial components enables immune discrimination between virulent and avirulent bacteria
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