Identifying Emotions in Social Media: Comparison of Word-emotion lexica

In recent years, emotions expressed in social media messages have become a vivid research topic due to their influence on the spread of misinformation and online radicalization over online social networks. Thus, it is important to correctly identify emotions in order to make inferences from social media messages. In this paper, we report on the performance of three publicly available word-emotion lexicons (NRC, DepecheMood, EmoSenticNet) over a set of Facebook and Twitter messages. To this end, we designed and implemented an algorithm that applies natural language processing (NLP) techniques along with a number of heuristics that reflect the way humans naturally assess emotions in written texts. In order to evaluate the appropriateness of the obtained emotion scores, we conducted a questionnaire-based survey with human raters. Our results show that there are noticeable differences between the performance of the lexicons as well as with respect to emotion scores the human raters provided in our surve

The insider on the outside: a novel system for the detection of information leakers in social networks

Confidential information is all too easily leaked by naive users posting comments. In this paper we introduce DUIL, a system for Detecting Unintentional Information Leakers. The value of DUIL is in its ability to detect those responsible for information leakage that occurs through comments posted on news articles in a public environment, when those articles have withheld material non-public information. DUIL is comprised of several artefacts, each designed to analyse a different aspect of this challenge: the information, the user(s) who posted the information, and the user(s) who may be involved in the dissemination of information. We present a design science analysis of DUIL as an information system artefact comprised of social, information, and technology artefacts. We demonstrate the performance of DUIL on real data crawled from several Facebook news pages spanning two years of news articles

When the Few Outweigh the Many: Illicit Content Recognition with Few-Shot Learning

The anonymity and untraceability benefits of the Dark web account for the exponentially-increased potential of its popularity while creating a suitable womb for many illicit activities, to date. Hence, in collaboration with cybersecurity and law enforcement agencies, research has provided approaches for recognizing and classifying illicit activities with most exploiting textual dark web markets' content recognition; few such approaches use images that originated from dark web content. This paper investigates this alternative technique for recognizing illegal activities from images. In particular, we investigate label-agnostic learning techniques like One-Shot and Few-Shot learning featuring the use Siamese neural networks, a state-of-the-art approach in the field. Our solution manages to handle small-scale datasets with promising accuracy. In particular, Siamese neural networks reach 90.9% on 20-Shot experiments over a 10-class dataset; this leads us to conclude that such models are a promising and cheaper alternative to the definition of automated law-enforcing machinery over the dark web

The applicability of a hybrid framework for automated phishing detection

peer reviewedPhishing attacks are a critical and escalating cybersecurity threat in the modern digital landscape. As cybercriminals continually adapt their techniques, automated phishing detection systems have become essential for safeguarding Internet users. However, many current systems rely on single-analysis models, making them vulnerable to sophisticated bypass attempts by hackers. This research delves into the potential of hybrid approaches, which combine multiple models to enhance both the robustness and effectiveness of phishing detection. It highlights existing hybrid models' limitations that focus primarily on effectiveness while ignoring broader applicability. To address these gaps, we introduce a novel framework explicitly designed for applicability in the real world, which poses the foundation for practical and robust phishing detection architectures. We develop a proof of concept to evaluate its effectiveness, robustness, and detection speed. Additionally, we introduce an innovative methodology for simulating bypass attacks on single-analysis base models. Our experiments demonstrate that the proposed hybrid framework outperforms individual models, displaying higher effectiveness, robustness against bypassing attempts, and real-time detection capabilities. Our proof of concept achieves an accuracy of 97.44% thereby outperforming the current state-of-the-art approach while requiring less computational time. The results provide insights into the multifaceted factors of hybrid models, extending beyond mere effectiveness, and emphasize the importance of holistic applicability in hybrid approaches to address the critical need for robust defenses against phishing attacks

Fotemustine plus etoposide, cytarabine and melphalan (FEAM) as a new conditioning regimen for lymphoma patients undergoing auto-SCT: A multicenter feasibility study

BEAM is a widely used conditioning regimen for relapsed/refractory lymphoma patients undergoing auto-SCT. We conducted a multicenter study with an alternative regimen (fotemustine plus etoposide, cytarabine and melphalan (FEAM)) in which BCNU was substituted by the chloroethylnitrosourea fotemustine (FTM). Eighty-four patients with relapsed/refractory Hodgkin's (n20) and non-Hodgkin's lymphoma (n64) were conditioned with a FEAM regimen (FTM 150 mg/m 2 on days -7, -6, etoposide 200 mg/m 2 and cytarabine 400 mg/m 2 on days -5, -4, -3, -2 and melphalan 140 mg/m 2 on day -1). Patients were evaluated for toxicity and engraftment parameters. Median times to neutrophil (500 × 10 9 /l) and plt (20 000 × 10 9 /l) engraftment were 11 and 13 days, respectively. Grade 3 mucositis occurred in 19 patients (23%), while G3 nausea/vomiting and G3 diarrhea were observed in 13 (15%) and 6 (7%) patients, respectively. No severe hepatic, renal or pulmonary toxicity was detected. Seven patients (7%) experienced G4 mucositis, while no other G4 toxicities or unexpected adverse events of any grade were recorded. Transplant-related mortality was 2.4%. We conclude that a FEAM regimen is feasible and safe. Although toxicity and engraftment times compared favorably with BEAM, longer follow-up is needed to evaluate fully its efficacy and long-term safety. © 2010 Macmillan Publishers Limited All rights reserved

Longitudinal Study of Optic Disk Perfusion and Retinal Structure in Leber's Hereditary Optic Neuropathy

PURPOSE. The purpose of this study was to evaluate optic disk perfusion and neural retinal structure in patients with subacute Leber's hereditary optic neuropathy (LHON) and LHON carriers, as compared with healthy controls. METHODS. This study included 8 patients with LHON in the subacute stage, 10 asymptomatic carriers of a LHON-associated mitochondrial DNA mutation, and 40 controls. All subjects underwent measurement of the retinal nerve fiber layer (RNFL) thickness, the ganglion cell-inner plexiform layer (GCIPL) thickness using optical coherence tomography and optic disk microvascular perfusion (Mean Tissue [MT]) using laser speckle flowgraphy (LSFG). Patients were re-examined after a median interval of 3 months from the baseline visit. RESULTS. LHON carriers had higher values of RNFL thickness, GCIPL thickness, and disk area than controls (P < 0.05), whereas MT was not different between the two groups (P = 0.936). Median MT and RNFL thickness were 32% and 15% higher in the early subacute stage of the disease than in controls (P < 0.001 and P = 0.001). MT declined below the values of controls during the late subacute stage (P = 0.024), whereas RNFL thickness declined later during the dynamic stage (P < 0.001). GCIPL thickness was lower in patients with LHON than in controls independently of the stage of the disease (P < 0.001). CONCLUSIONS. The high blood flow at the optic disk during the early subacute stage may be the consequence of vasodilation due to nitric oxide release as compensation to mitochondrial impairment. Optic disk perfusion as measured by LSFG is a promising biomarker for LHON diagnosis and monitoring as well as an objective outcome measure for assessing response to therapies

Absolute monocyte count and lymphocyte-monocyte ratio predict outcome in nodular sclerosis Hodgkin lymphoma: Evaluation based on data from 1450 patients

Objective: To verify whether absolute monocyte count (AMC) and lymphocyte-monocyte ratio (LMR) at diagnosis are valid prognostic parameters in classical Hodgkin lymphoma (cHL). Patients and Methods: Data were collected from 1450 patients with cHL treated in Israel and Italy from January 1, 1988, through December 31, 2007. Results: The median age of the patients was 33 years (range, 17-72 years), and 70% (1017) of the patients had nodular sclerosis (NS); the median follow-up duration was 87 months. The best cutoff value for AMC was 750 cells/mm3, and the best ratio for LMR was 2.1. The adverse prognostic impact of an AMC of more than 750 cells/mm(3) was confirmed for the entire cohort, and its clinical significance was particularly evident in patients with NS histology. The progression-free survival (PFS) at 10 years for an AMC of more than 750 cells/mm(3) was 65% (56%-72%), and the PFS at 10 years for an AMC of 750 cells/mm(3) or less was 81% (76%-84%; P<.001). The overall survival (OS) at 10 years for an AMC of more than 750 cells/mm3 was 78% (70%-85%), and the OS at 10 years for an AMC of 750 cells/mm(3) or less was 88% (84%-90%; P=.01). In multivariate analysis, both AMC and LMR maintained prognostic significance for PFS (hazard ratio [HR], 1.54, P=.006, and HR, 1.50, P=.006) after adjusting for the international prognostic score, whereas the impact on OS was confirmed (HR, 1.56; P=.04) only in patients with NS and an AMC of more than 750 cells/mm(3). Conclusion: This study confirms that AMC has prognostic value in cHL that is particularly significant in patients with NS subtype histology. This finding links the known impact of macrophages and monocytes in Hodgkin lymphoma with routine clinical practice

Retinal vascular impairment in Wolfram syndrome: an optical coherence tomography angiography study

To evaluate differences in macular and optic disc circulation in patients affected by Wolfram Syndrome (WS) employing optical coherence tomography-angiography (OCTA) imaging. In this retrospective study, 18 eyes from 10 WS patients, 16 eyes of 8 patients affected by type I diabetes and 17 eyes from 17 healthy controls were enrolled. All patients were imaged through OCT and OCTA and vascular parameters, as perfusion density (PD) and vessel length density (VLD) were measured. OCTA showed reduced PD in WS patients at the macular superficial capillary plexus (SCP, 27.8 ± 5.3%), deep vascular complex (DVC, 33.2 ± 1.9%) and optic nerve head (ONH, 21.2 ± 9.1%) compared to both diabetic patients (SCP 33.9 ± 1.9%, P &lt; 0.0001; DVC 33.2 ± 0.7%, P = 1.0; ONH 33.9 ± 1.3, P &lt; 0.0001) and healthy controls (SCP 31.6 ± 2.5, P = 0.002; DVC 34.0 ± 0.7%, P = 0.089; ONH 34.6 ± 0.8%, P &lt; 0.0001). Similarly, VLD was lower in WS patients at the SCP (10.9 ± 2.7%) and ONH levels (7.5 ± 4.1%) compared to diabetic patients (SCP 13.8 ± 1.2%, P = 0.001; DVC 13.8 ± 0.2%, P &lt; 0.0001; ONH 13.0 ± 0.7%, P = &lt; 0.0001), but higher in DVC (15.7 ± 1.2%, P &lt; 0.0001). Furthermore, VLD was lower in WS patients in all the vascular parameters compared to controls (SCP 13.8 ± 1.5%, P &lt; 0.0001; DVC 17.3 ± 0.6%, P &lt; 0.0001; ONH 15.7 ± 0.5%, P &lt; 0.0001). A significant microvasculature impairment in the macular SCP and ONH microvasculature was demonstrated in eyes affected by WS. Microvascular impairment may be considered a fundamental component of the neurodegenerative changes in WS

Capturing the Pattern of Transition From Carrier to Affected in Leber Hereditary Optic Neuropathy

center dot PURPOSE: To capture the key features patterning the transition from unaffected mutation carriers to clinically affected Leber hereditary optic neuropathy (LHON), as investigated by optical coherence tomography. center dot DESIGN: Observational case series. center dot METHODS: Four unaffected eyes of 4 patients with LHON with the first eye affected were followed across conversion to affected, from 60 days before to 170 days after conversion. The primary outcome measures were multiple timepoints measurements of peripapillary retinal nerve fiber layer (RNFL) thickness for temporal emiside of the optic nerve (6 sectors from 6-11, clockwise for the right eye and counterclockwise for the left eye) in all patients and nasal emi-macular RNFL and ganglion cell layer (GCL) thickness in 2 patients. center dot RESULTS: While the presymptomatic stage was characterized by a dynamic thickening of sector 8, the beginning of the conversion coincided with an increase in the thickness of the sectors bordering the papillo-acular bundle (6 and 7 for the inferior sectors, 10 and 11 for the superior sectors) synchronous with the thinning of sectors 8 and then 9. Conversely, the GCL did not undergo significant changes until the onset of visual loss when a significant reduction of thickness became evident. center dot CONCLUSION: In this study we demonstrated that the thinning of sector 8 can be considered the structural hallmark of the conversion from the presymptomatic to the affected state in LHON. It is preceded by its own progressive thickening extending from th