Comparison of Two Reminder Interventions to Achieve Adequate Water Intake and Hydration in Women: A Pilot Study

Introduction: This pilot study examined the effectiveness of 2 different 5-week reminder interventions to achieve adequate water intake and hydration in women as well as the effects of body composition and self-efficacy on hydration. Methods: Twenty-two apparently healthy adult women were randomly assigned to the 64 oz. motivational water bottle group (n = 11), or the water reminder – daily tracker app group (n = 11). Body composition, predicted VO2max, and self-efficacy were assessed at baseline, post 5-week intervention, and after a 30-day follow-up period. Urine markers (color, specific gravity, and pH) were reported at baseline, weekly throughout the 5-week intervention, and the last 3 days of the 30-day follow-up period. During the interventions, participants self-reported daily step count, resting heart rate, water intake, and symptoms of dehydration. Results: Both 5-week reminder interventions successfully increased water intake by an average of 29% with a mean daily consumption of 72.05 + 18.75 ounces, meeting recommendations. Based on regression analysis, self-efficacy predicted daily water intake at the end of the 5-week intervention (p = 0.03). Urine markers of hydration classified several participants as dehydrated at the end of 5 weeks. In addition, there was a significant inverse relationship between BMI and Ucol at baseline (p = 0.05), week 5 (p = 0.05), and follow-up (p = 0.04), indicating that women with a higher BMI were more dehydrated. In hydrated participants, memory and ability to concentrate significantly improved (p = 0.019). Results indicated there were no significant differences in water intake and hydration between the 2 groups at baseline, week 5, and follow-up. Conclusions: Both 5-week interventions successfully increased water intake. However, based on urine markers of hydration women may be more prone to involuntary, chronic dehydration due to a higher body fat percentage

Microclustering: When the Cluster Sizes Grow Sublinearly with the Size of the Data Set

Most generative models for clustering implicitly assume that the number of data points in each cluster grows linearly with the total number of data points. Finite mixture models, Dirichlet process mixture models, and Pitman--Yor process mixture models make this assumption, as do all other infinitely exchangeable clustering models. However, for some tasks, this assumption is undesirable. For example, when performing entity resolution, the size of each cluster is often unrelated to the size of the data set. Consequently, each cluster contains a negligible fraction of the total number of data points. Such tasks therefore require models that yield clusters whose sizes grow sublinearly with the size of the data set. We address this requirement by defining the \emph{microclustering property} and introducing a new model that exhibits this property. We compare this model to several commonly used clustering models by checking model fit using real and simulated data sets

Population based screening for chronic kidney disease: cost effectiveness study

Objective To determine the cost effectiveness of one-off population based screening for chronic kidney disease based on estimated glomerular filtration rate

Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1

Presenilin (PS1 or PS2) is an essential component of the active γ-secretase complex that liberates the Aβ peptides from amyloid precursor protein (APP). PS1 is regarded as an atypical aspartyl protease harboring two essential aspartic acids in the context of the sequence D257LV and D385FI, respectively, rather than the typical DTG...DTG catalytic motif of classical aspartyl proteases. In the present studies, we introduced the sequence DTG in PS1 at and around the catalytic D257 and D385 residues to generate three PS1 mutants: D257TG, D385TG, and the double-mutant D257TG/D385TG. The effects of these changes on the γ-secretase activity in the presence or absence of γ-secretase inhibitors and modulators were investigated. The results showed that PS1 mutants having D385TG robustly enhanced Aβ42 production compared to the wild type (wt), and were more sensitive than wt to inhibition by a classical aspartyl protease transition state mimic, and fenchylamine, a sulfonamide derivative. Unlike wt PS1 and some of its clinical mutants, all three PS1 artificial mutants decreased cleavage of Notch S3-site, suggesting that these artificial mutations may trigger conformational changes at the substrate docking and catalytic site that cause alteration of substrate specificity and inhibition pattern. Consistent with this notion, we have found that NSAID enzymatic inhibitors of COX, known modulators of the γ-secretase activity, cause PS1 mutants containing D385TG to produce higher levels of both Aβ38 and Aβ42, but to reduce levels of Aβ39, showing a pattern of Aβ formation different from that observed with wild type PS1 and its clinical mutants. This study provides an important structural clue for the rational design of drugs to inhibit processing of APP at the γ-site without interfering with Notch processing

Escaping Poverty Traps and Unlocking Prosperity in the Face of Climate Risk: Lessons from Index-Based Livestock Insurance

This Element outlines the origins and evolution of an international award-winning development intervention, index-based livestock insurance (IBLI), which scaled from a small pilot project in Kenya to a design that underpins drought risk management products and policies across Africa. General insights are provided on i) the economics of poverty, risk management, and drylands development; ii) the evolving use of modern remote sensing and data science tools in development; iii) the science of scaling; and iv) the value and challenges of integrating research with operational implementation to tackle development and humanitarian challenges in some of the world's poorest regions. This title is also available as Open Access on Cambridge Core

Global distribution of invasive serotype 35D streptococcus pneumoniae isolates following introduction of 13-valent pneumococcal conjugate vaccine

A newly recognized pneumococcal serotype 35D, which differs from the 35B polysaccharide in structure and serology by not binding to factor serum 35a, was recently reported. The genetic basis for this distinctive serology is due to the presence of an inactivating mutation in wciG, which encodes an O-acetyltransferase responsible for O-acetylation of a galactofuranose. Here, we assessed the genomic data of a worldwide pneumococcal collection to identify serotype 35D isolates and understand their geographical distribution, genetic background and invasiveness potential. Of 21,980 pneumococcal isolates, 444 were originally typed as serotype 35B by PneumoCaT. Analysis of wciGrevealed 23 isolates from carriage (n=4) and disease (n=19) with partial or complete loss-of-funtion mutations, including mutations resulting in pre-mature stop codons (n=22) and an in-frame mutation (n=1). These were selected for further analysis. The putative 35D isolates were geographically widespread and 65.2% (15/23) of them was recovered after PCV13 introduction. Compared with serotype 35B, putative serotype 35D isolates have higher invasive disease potentials based on odds ratio (OR) (11.58; 95% CI, 1.42-94.19 vs 0.61; 95% CI, 0.40-0.92) and a higher prevalence of macrolide resistance mediated by mefA (26.1% vs 7.6%, p=0.009). Using Quellung, 50% (10/20) of viable isolates were serotype 35D, 25% (5/20) serotype 35B, and 25% (5/20) a mixture of 35B/35D. The discrepancy between phenotype and genotype requires further investigation. These findings illustrated a global distribution of an invasive serotype 35D among young children post-PCV13 introduction and underlined the invasive potential conferred by the loss of O-acetylation in the pneumococcal capsule

Collage Concert 2021

An exciting highlight of each season, Collage is the signature annual production of the School of Music. All proceeds and donations support student scholarships. This unique production features over 200 student and faculty performers. The featured highlighted ensembles include jazz, orchestra, choir, band, percussion, opera, chamber groups, and much more. This year, Collage is free and you may live-stream the event from the comfort of your home.https://digitalcommons.kennesaw.edu/musicprograms/2368/thumbnail.jp

Halogen Oxidation Reactions of (C5Ph5)Cr(CO)3 and Lewis Base Addition To [(C5Ph5)Cr(μ-X)X]2: Electrochemical, Magnetic, and Raman Spectroscopic Characterization of [(C5Ph5)CrX2]2 and (C5Ph5)CrX2(THF) (X = Cl, Br, I). X-ray Crystal Structure of [(C5Ph5)Cr(μ-Cl)Cl]2

The 17-electron complex (C5Ph5)Cr(CO)3 reacts with halogens (C6H5I•Cl2, Br2, and I2) in C6H6 to yield the dimeric oxidation products [(C5Ph5)Cr(m-X)X]2 as thermally stable solids. Reactions with other chlorinating agents similarly yield [(C5Ph5)CrCl2]2. An X-ray crystal structure of [(C5Ph5)Cr(m-Cl)Cl]2 was obtained. The magnetic properties of the Cl2 bridged dimer have been determined and modeled using the usual isotropic hamiltonian which yields J/k = –30 K. Low-temperature (77 K) Raman spectra of solid [(C5Ph5)CrX2]2 (X = Cl, I) allow assignments to be made for the metal-ring and metal halogen stretching modes in the low frequency region (\u3c 600 cm-1). Tetrahydrofuran (THF) cleaves these dimers to yield complexes of the form (C5Ph5)CrX2(THF)