Reporting guideline and clinical trial registration adherence in nephrology journals: Results of a preliminary systematic review

Background: Clinicians rely on relevant, high-quality research to inform their decisions regarding patient care. This research is held to a higher standard when journals implement reporting guidelines and clinical trial registration into article submission requirements. Due to the small number of nephrology journals — and the growing yet still limited research in the field — it is of the utmost importance for these journals to apply stringent guidelines to ensure the publication of limited bias and high quality research. However, the extent of reporting guideline adoption and clinical trial registration policies among nephrology journals is unknown. Therefore, the purpose of this study is to examine the recommendation or requirement of reporting guidelines and clinical trial registration in nephrology journals.Methods: The 2021 Scopus CiteScore Tool was used to identify 62 journals in the “Nephrology” subcategory. In a masked, duplicate fashion, we examined the “Instructions for Authors'' webpage of each included journal to determine whether the following reporting guidelines — outlined by the Enhancing the Quality and Transparency of health Research (EQUATOR) Network — were recommended or required: PRISMA, CONSORT, PRISMA-P, STARD, TRIPOD, MOOSE, ARRIVE, CHEERS, QUOROM, STROBE, CARE, SRQR, SPIRIT, and COREQ. Clinical trial registration statements were investigated in a similar fashion. Journal statements were documented as “Not mentioned”, “Recommended”, “Required”, or “Does Not Require”. Stata 17.0 was used to analyze the data. To minimize bias, all journals were contacted to confirm their accepted article types.Results: The most frequently mentioned guidelines were CONSORT, STROBE, and PRISMA. Of the 62 nephrology journals investigated, CONSORT was required by 11 (18%) and recommended by 34 (55%) journals. Furthermore, STROBE was required by 7 (11%) and recommended by 27 (44%) journals, and PRISMA was required by 8 (13%) and recommended by 18 (29%) journals. The least frequently mentioned guidelines were QUOROM (0/62, 0%), PRISMA-P (24/60, 40%), and MOOSE (26/62, 42%). Finally, 32 (52%) of journals required and 19 (31%) of journals recommended clinical trial registration.Discussion: These findings illuminate the variable adoption of reporting guidelines and inconsistent clinical trial registration policies across nephrology journals. We recommend that journal editors in this field require more author adherence to guidelines to improve the quality of research submitted to and published by their journals

Vertebrate Natural History Notes from Arkansas, 2020

Smaller details of natural history often go undocumented to science if those details are not parts of larger studies, but small details can provide insights that lead to interesting questions about ecological relationships or environmental change. We have compiled recent important observations of distribution and reproduction of fishes and mammals. Included are new distributional records of mammals, and observations of reproduction in several mammals for which few data exist in Arkansas. A rare record of the Long-tailed weasel, a special of special concern in Arkansas, is documented from Newton Co. We also provide evidence that Seminole bats likely reproduce in Arkansas

VCU Jazz Orchestra I

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Antibodies Against Human BLyS and APRIL Attenuate EAE Development in Marmoset Monkeys

B lymphocyte stimulator (BLyS, also indicated as BAFF (B-cell activating factor) and CD257), and A Proliferation Inducing Ligand (APRIL, CD256) are two members of the TNF superfamily with a central role in B cell survival. Antibodies against these factors have potential therapeutic relevance in autoimmune inflammatory disorders with a proven pathogenic contribution of B cells, such as multiple sclerosis (MS). In the current study we performed a multi-parameter efficacy comparison of monoclonal antibodies against human anti-BLyS and anti-APRIL in a common marmoset (Callithrix jacchus) model of experimental autoimmune encephalomyelitis (EAE). A MS-like disease was induced by immunization with recombinant human myelin/oligodendrocyte glycoprotein (rhMOG) in complete Freund's adjuvant. The results show that the anti-BLyS and anti-APRIL antibody cause significant depletion of circulating CD20+ B cells, but a small subset of CD20 + CD40highB cells was not depleted. Induction of CD20+ B cell depletion from lymph nodes was only observed in the anti-BLyS treated monkeys. Both antibodies had a significant inhibitory effect on disease development, but all monkeys developed clinically evident EAE. Anti-BLyS treated monkeys were sacrificed with the same clinical signs as saline-treated monkeys, but nevertheless displayed significantly reduced spinal cord demyelination. This effect was not observed in the anti-APRIL treated monkeys. The two antibodies had a different effect on T cell subset activation and the profiles of ex vivo released cytokines. In conclusion, treatment with anti-BLyS and anti-APRIL delays the development of neurological disease in a relevant preclinical model of MS. The two mAbs achieve this effect via different mechanisms

Survival among older adults with kidney failure is better in the first three years with chronic dialysis treatment than not

Comparisons of survival between dialysis and nondialysis care for older adults with kidney failure have been limited to those managed by nephrologists, and are vulnerable to lead and immortal time biases. So we compared time to all-cause mortality among older adults with kidney failure treated vs. not treated with chronic dialysis. Our retrospective cohort study used linked administrative and laboratory data to identify adults aged 65 or more years of age in Alberta, Canada, with kidney failure (2002-2012), defined by two or more consecutive outpatient estimated glomerular filtration rates less than 10 mL/min/1.73m2, spanning 90 or more days. We used marginal structural Cox models to assess the association between receipt of dialysis and all-cause mortality by allowing control for both time-varying and baseline confounders. Overall, 838 patients met inclusion criteria (mean age 79.1; 48.6% male; mean estimated glomerular filtration rate 7.8 mL/min/1.73m2). Dialysis treatment (vs. no dialysis) was associated with a significantly lower risk of death for the first three years of follow-up (hazard ratio 0.59 [95% confidence interval 0.46-0.77]), but not thereafter (1.22 [0.69-2.17]). However, dialysis was associated with a significantly higher risk of hospitalization (1.40 [1.16-1.69]). Thus, among older adults with kidney failure, treatment with dialysis was associated with longer survival up to three years after reaching kidney failure, though with a higher risk of hospital admissions. These findings may assist shared decision-making about treatment of kidney failure

The Lantern, 2017-2018

On Dissociation • Untouchable • After Rocket Man • The Science Fair • Cardinal Rule at Stephen J. Memorial • Quentin & Sylvie • Cabello • The Get Out • Painting Day • Black, White and Grey • Family Pruning • How to Remove a Stain • Becoming Ourselves • Wonderbread U • Overture • Pescadero • Gross • Stage Fright • Lucky Daddy • Sarah • Rumble • Silvermine • The Green Iguana • A Poem for Ghost Children • A Poem for Lost Boys • Mother • Drop of Grease • Don\u27t Wanna be White • I • Amelia Earhart Disappeared Into My Vagina: An Ode to Cunts, Menstrual Cups and All Things Woman • Suburban Summer • Nightmares and Dreams Induced by My Mother • Teacups, Skins, etc. • Three Thoughts About My Bedroom • Dear Siri • 2 Queens (Beyonce in Reference to Sonia Sanchez) • Voyeurs • In Front of the Bathroom Mirror • To a Rose • Howl • Mice • Mirror • Language Accordion Volcano Mouth • Lucky Woman • Butterscotch • To Persephone • Wolf • Notes Never Passed • Topple • Bust • Kyoto • Identity • Sunflower • Tornabuoni Bubbles • Olympia • Decayed Hall • Perspectivehttps://digitalcommons.ursinus.edu/lantern/1186/thumbnail.jp