"A Prison within a Prison”?: Examining the enfolding spatialities of care and control in the Barlinnie Special Unit

This paper uses one of Scotland's most controversial experiments in penal reform – the Barlinnie Special Unit – to examine the enfolding nature of care and control in carceral space. Connecting with recent arguments relating to “caring architecture” and using the framework of historical carceral geographies, it showcases the spatial complexities of implementing caring practices alongside reforming tactics. Beginning with a discussion of the care and control nexus within institutional spaces and its historical legacy, it considers the use of small units within the Scottish Prison System. Using the Barlinnie Special Unit as a pivot, the paper opens up the complex spatial arrangements and spatial tactics of experimental prison reform. It first examines the spatial and architectural dimensions of the Special Unit. Second, the paper focuses on issues of routine and inhabitation and the emotional uncertainty this generated for prisoners. Overall, this paper seeks to argue the importance of examining experimental spatial practices in prison reform history to highlight the interwoven spatialities of care and control in every‐day institutional life

Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

The serine proteases sequentially activated to form a fibrin clot are inhibited primarily by members of the serpin family, which use a unique β-sheet expansion mechanism to trap and destroy their targets. Since the discovery that serpins were a family of serine protease inhibitors there has been controversy as to the role of conformational change in their mechanism. It now is clear that protease inhibition depends entirely on rapid serpin β-sheet expansion after proteolytic attack. The regulatory advantage afforded by the conformational mobility of serpins is demonstrated here by the structures of native and S195A thrombin-complexed heparin cofactor II (HCII). HCII inhibits thrombin, the final protease of the coagulation cascade, in a glycosaminoglycan-dependent manner that involves the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. The native structure of HCII resembles that of native antithrombin and suggests an alternative mechanism of allosteric activation, whereas the structure of the S195A thrombin–HCII complex defines the molecular basis of allostery. Together, these structures reveal a multistep allosteric mechanism that relies on sequential contraction and expansion of the central β-sheet of HCII

GALEX J201337.6+092801: The lowest gravity subdwarf B pulsator

We present the recent discovery of a new subdwarf B variable (sdBV), with an exceptionally low surface gravity. Our spectroscopy of J20136+0928 places it at Teff = 32100 +/- 500, log(g) = 5.15 +/- 0.10, and log(He/H) = -2.8 +/- 0.1. With a magnitude of B = 12.0, it is the second brightest V361 Hya star ever found. Photometry from three different observatories reveals a temporal spectrum with eleven clearly detected periods in the range 376 to 566 s, and at least five more close to our detection limit. These periods are unusually long for the V361 Hya class of short-period sdBV pulsators, but not unreasonable for p- and g-modes close to the radial fundamental, given its low surface gravity. Of the ~50 short period sdB pulsators known to date, only a single one has been found to have comparable spectroscopic parameters to J20136+0928. This is the enigmatic high-amplitude pulsator V338 Ser, and we conclude that J20136+0928 is the second example of this rare subclass of sdB pulsators located well above the canonical extreme horizontal branch in the HR diagram.Comment: 5 pages, accepted for publication in ApJ Letter

An analytical approach to characterize morbidity profile dissimilarity between distinct cohorts using electronic medical records

AbstractWe describe a two-stage analytical approach for characterizing morbidity profile dissimilarity among patient cohorts using electronic medical records. We capture morbidities using the International Statistical Classification of Diseases and Related Health Problems (ICD-9) codes. In the first stage of the approach separate logistic regression analyses for ICD-9 sections (e.g., “hypertensive disease” or “appendicitis”) are conducted, and the odds ratios that describe adjusted differences in prevalence between two cohorts are displayed graphically. In the second stage, the results from ICD-9 section analyses are combined into a general morbidity dissimilarity index (MDI). For illustration, we examine nine cohorts of patients representing six phenotypes (or controls) derived from five institutions, each a participant in the electronic MEdical REcords and GEnomics (eMERGE) network. The phenotypes studied include type II diabetes and type II diabetes controls, peripheral arterial disease and peripheral arterial disease controls, normal cardiac conduction as measured by electrocardiography, and senile cataracts

Hydrogen lines in LAMOST low-resolution spectra of RR Lyrae stars

AbstractThe LAMOST pilot survey has produced a data release containing over 600,000 stellar spectra. By cross-checking with a large time series photometric database of RR Lyrae stars in high Galactic latitude regions, we found a total number of 157 RR Lyrae stars that have been observed with LAMOST. In this sample, we successfully captured three RR Lyrae stars in the fast expansion phase, all of them showing hypersonic shock wave features in the Balmer line region. We fit the shape of Hα line region and determine that the emission feature seen within the broadened Hα absorption line suggests hypersonic relative motion in the atmospheres of these three objects. With a further LAMOST survey of millions of stars, we plan to capture a large sample of RR Lyrae stars in their hypersonic expansion phase, and therefore provide a large database for the study of the internal structure and the pulsation mechanism of RR Lyrae stars