Alteración estructural del colorante azul de metileno con compuestos orgánicos

Las diversas estructuras que presentan la mayoría de los colorantes sintéticos les confiere una gran estabilidad. La presencia de grupos cromóforos es la consecuencia de la generación de un determinado color, así como la existencia de grupos auxocromos que determinan la intensidad del color. (F. Klages, 1968) el presente trabajo tiene como objetivo el uso de compuestos orgánicos, tipo α-diiminas, con la finalidad de provocar una alteración estructural del colorante azul de metileno; proponiendo dicha modificación como clave para la pérdida o cambio de algunas propiedades físicas o químicas de este colorante; ocasionando con esto una variación en su estabilidad. La reacción entre las α diiminas sintetizadas y el colorante azul de metileno fue evaluada por espectroscopia UV-visible, observando disminuciones significativas en la absorbancia.The various structures which have the most synthetic dyes present them great stability. The presence of chromophore groups is due to the generation of a certain color, and the existence of auxochrome groups determining color intensity. This work aims to use α diimine, organic compounds, such in order to cause a structural alteration of methylene blue dye; proposing this amendment as the key to the loss or change of some physical or chemical properties of this dye; with this causing a variation in its stability. The reaction between the α-diimine synthesized and methylene blue dye was evaluated at different times by UV- visible spectroscopy, observing significant decreases in absorbance

Síntesis de Iminas

El presente trabajo tiene como objetivo la síntesis de iminas en microondas a partir de 4-aminobifenil con cinamaldehído y 4-aminobifenil con p-dimetilbenzaldehído, las reacciones fueron monitoreadas por cromatografía en capa fina, finalmente fueron purificadas y caracterizadas por espectroscopia de rutina.This paper aims at the synthesis of imines in microwave from 4-aminobiphenyl with cinnamaldehyde and 4-aminobiphenyl with p-dimethylbenzaldehyde, the reactions were monitored by thin layer chromatography, finally purified and characterized by spectroscopy routine

Green Production of Indolylquinones, Derivatives of Perezone, and Related Molecules, Promising Antineoplastic Compounds

A green approach to produce the indolyl derivatives from four natural quinones (perezone, isoperezone, menadione, and plumbagin) was performed; in this regard, a comparative study was accomplished among the typical mantle heating and three nonconventional activating modes of reaction (microwave, near-infrared, and high speed ball milling or tribochemical), under solventless conditions and using bentonitic clay as a catalyst. In addition, the tribochemical production of isoperezone from perezone is also commented on. It is also worth noting that the cytotoxicity of the synthesized indolylquinones in human breast cancer cell was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, with the 3-indolylisoperezone being the most active. The structural attribution of the target molecules was performed by typical spectroscopic procedures; moreover, the experimental and computed 1H and 13C NMR chemical shifts data, with previous acquisition of the corresponding minimum energetic structures, were in good agreement