Measurement of Circumstellar Disk Sizes in the Upper Scorpius OB Association with ALMA

We present detailed modeling of the spatial distributions of gas and dust in 57 circumstellar disks in the Upper Scorpius OB Association observed with ALMA at sub-millimeter wavelengths. We fit power-law models to the dust surface density and CO $J$ = 3-2 surface brightness to measure the radial extent of dust and gas in these disks. We found that these disks are extremely compact: the 25 highest signal-to-noise disks have a median dust outer radius of 21 au, assuming an $R^{-1}$ dust surface density profile. Our lack of CO detections in the majority of our sample is consistent with these small disk sizes assuming the dust and CO share the same spatial distribution. Of seven disks in our sample with well-constrained dust and CO radii, four appear to be more extended in CO, although this may simply be due to higher optical depth of the CO. Comparison of the Upper Sco results with recent analyses of disks in Taurus, Ophiuchus, and Lupus suggests that the dust disks in Upper Sco may be $\sim3$ times smaller in size than their younger counterparts, although we caution that a more uniform analysis of the data across all regions is needed. We discuss the implications of these results for disk evolution.Comment: 15 pages of text, 7 figures, 3 tables. Accepted in Ap

The AdHOC study of older adults’ adherence to medication in 11 countries

BACKGROUND: Compared with the resources expended developing, evaluating and making clinical decisions about prescribing medication, we know little about what determines whether people take it. Older adults are prescribed more medication than any other group. Poor adherence is a common reason for nonresponse to medication. OBJECTIVES: To investigate cross-nationally the impact of demographic, psychiatric (including cognitive), physical health, behavioural and medication factors on adherence to medication in older adults. METHODS: Researchers interviewed 3881 people over 65 who receive home care services using a structured interview at participants’ places of residence in eleven countries. The main outcome measure was the percentage participants not adherent to medication. RESULTS: 12.5% (n= 456) of people reported they were not fully adherent to medication. Non-adherence was predicted by problem drinking (OR=3.6), not having a doctor review medication (OR=3.3), dementia (OR=1.4 for every one point increase in impairment), good physical health (OR=1.2), resisting care (OR=2.1) being married (OR=2.3) and living in the Czech Republic (OR=4.7) or Germany (OR=1.4). CONCLUSION: People, who screen positive for problem drinking and with dementia, often undiagnosed are less likely to adhere to medication. Therefore doctors should consider dementia and problem drinking when prescribing for older adults. Interventions to improve adherence in older adults might be more effective if 4 targeted at these groups. It is possible that medication review enhances adherence, by improving the patient-doctor relationship, or by emphasising the relevance of medications

The Spectroscopically Determined Substellar Mass Function of the Orion Nebula Cluster

We present a spectroscopic study of candidate brown dwarf members of the Orion Nebula Cluster (ONC). We obtained new J- and/or K-band spectra of ~100 objects within the ONC which are expected to be substellar based on their K,(H-K) magnitudes and colors. Spectral classification in the near-infrared of young low mass objects is described, including the effects of surface gravity, veiling due to circumstellar material, and reddening. From our derived spectral types and existing near-infrared photometry we construct an HR diagram for the cluster. Masses are inferred for each object and used to derive the brown dwarf fraction and assess the mass function for the inner 5.'1 x 5.'1 of the ONC, down to ~0.02 solar masses. The derived logarithmic mass function rises to a peak at ~0.2 solar masses, similar to previous IMF determinations derived from purely photometric methods, but falls off more sharply at the hydrogen-burning limit before leveling through the substellar regime. We compare the mass function derived here for the inner ONC to those presented in recent literature for the sparsely populated Taurus cloud members and the rich cluster IC 348. We find good agreement between the shapes and peak values of the ONC and IC 348 mass distributions, but little similarity between the ONC and Taurus results.Comment: Accepted for Publication in Apj. Added Erratu

The circumbinary disk of HD 98800B: Evidence for disk warping

The quadruple young stellar system HD 98800 consists of two spectroscopic binary pairs with a circumbinary disk around the B component. Recent work by Boden and collaborators using infrared interferometry and radial velocity data resulted in a determination of the physical orbit for HD 98800B. We use the resulting inclination of the binary and the measured extinction toward the B component stars to constrain the distribution of circumbinary material. Although a standard optically and geometrically thick disk model can reproduce the spectral energy distribution, it cannot account for the observed extinction if the binary and the disk are coplanar. We next constructed a dynamical model to investigate the influence of the A component, which is not in the Ba‐Bb orbital plane, on the B disk. We find that these interactions have a substantial impact on the inclination of the B circumbinary disk with respect to the Ba‐Bb orbital plane. The resulting warp would be sufficient to place material into the line of sight and the noncoplanar disk orientation may also cause the upper layers of the disk to intersect the line of sight if the disk is geometrically thick. These simulations also support that the dynamics of the Ba‐Bb orbit clear the inner region to a radius of~3 AU. We then discuss whether the somewhat unusual properties of the HD 98800B disk are consistent with material remnant from the star formation process or with more recent creation by collisions from larger bodies

Recognition of 3-D Objects from Multiple 2-D Views by a Self-Organizing Neural Architecture

The recognition of 3-D objects from sequences of their 2-D views is modeled by a neural architecture, called VIEWNET that uses View Information Encoded With NETworks. VIEWNET illustrates how several types of noise and varialbility in image data can be progressively removed while incornplcte image features are restored and invariant features are discovered using an appropriately designed cascade of processing stages. VIEWNET first processes 2-D views of 3-D objects using the CORT-X 2 filter, which discounts the illuminant, regularizes and completes figural boundaries, and removes noise from the images. Boundary regularization and cornpletion are achieved by the same mechanisms that suppress image noise. A log-polar transform is taken with respect to the centroid of the resulting figure and then re-centered to achieve 2-D scale and rotation invariance. The invariant images are coarse coded to further reduce noise, reduce foreshortening effects, and increase generalization. These compressed codes are input into a supervised learning system based on the fuzzy ARTMAP algorithm. Recognition categories of 2-D views are learned before evidence from sequences of 2-D view categories is accumulated to improve object recognition. Recognition is studied with noisy and clean images using slow and fast learning. VIEWNET is demonstrated on an MIT Lincoln Laboratory database of 2-D views of jet aircraft with and without additive noise. A recognition rate of 90% is achieved with one 2-D view category and of 98.5% correct with three 2-D view categories.National Science Foundation (IRI 90-24877); Office of Naval Research (N00014-91-J-1309, N00014-91-J-4100, N00014-92-J-0499); Air Force Office of Scientific Research (F9620-92-J-0499, 90-0083

Carboxyl-modified single-wall carbon nanotubes improve bone tissue formation in vitro and repair in an in vivo rat model.

The clinical management of bone defects caused by trauma or nonunion fractures remains a challenge in orthopedic practice due to the poor integration and biocompatibility properties of the scaffold or implant material. In the current work, the osteogenic properties of carboxyl-modified single-walled carbon nanotubes (COOH-SWCNTs) were investigated in vivo and in vitro. When human preosteoblasts and murine embryonic stem cells were cultured on coverslips sprayed with COOH-SWCNTs, accelerated osteogenic differentiation was manifested by increased expression of classical bone marker genes and an increase in the secretion of osteocalcin, in addition to prior mineralization of the extracellular matrix. These results predicated COOH-SWCNTs' use to further promote osteogenic differentiation in vivo. In contrast, both cell lines had difficulties adhering to multi-walled carbon nanotube-based scaffolds, as shown by scanning electron microscopy. While a suspension of SWCNTs caused cytotoxicity in both cell lines at levels >20 μg/mL, these levels were never achieved by release from sprayed SWCNTs, warranting the approach taken. In vivo, human allografts formed by the combination of demineralized bone matrix or cartilage particles with SWCNTs were implanted into nude rats, and ectopic bone formation was analyzed. Histological analysis of both types of implants showed high permeability and pore connectivity of the carbon nanotube-soaked implants. Numerous vascularization channels appeared in the formed tissue, additional progenitor cells were recruited, and areas of de novo ossification were found 4 weeks post-implantation. Induction of the expression of bone-related genes and the presence of secreted osteopontin protein were also confirmed by quantitative polymerase chain reaction analysis and immunofluorescence, respectively. In summary, these results are in line with prior contributions that highlight the suitability of SWCNTs as scaffolds with high bone-inducing capabilities both in vitro and in vivo, confirming them as alternatives to current bone-repair therapies

Spin transition in Gd3_3N@C80_{80}, detected by low-temperature on-chip SQUID technique

We present a magnetic study of the Gd$_3$N@C$_{80}$ molecule, consisting of a Gd-trimer via a Nitrogen atom, encapsulated in a C$_{80}$ cage. This molecular system can be an efficient contrast agent for Magnetic Resonance Imaging (MRI) applications. We used a low-temperature technique able to detect small magnetic signals by placing the sample in the vicinity of an on-chip SQUID. The technique implemented at NHMFL has the particularity to operate in high magnetic fields of up to 7 T. The Gd$_3$N@C$_{80}$ shows a paramagnetic behavior and we find a spin transition of the Gd$_3$N structure at 1.2 K. We perform quantum mechanical simulations, which indicate that one of the Gd ions changes from a $^8S_{7/2}$ state ($L=0, S=7/2$) to a $^7F_{6}$ state ($L=S=3, J=6$), likely due to a charge transfer between the C$_{80}$ cage and the ion

Phase transitions and phase diagram of the ferroelectric perovskite NBT-BT by anelastic and dielectric measurements

The complex elastic compliance and dielectric susceptibility of (Na_{0.5}Bi_{0.5})_{1-x}Ba_{x}TiO_{3} (NBT-BT) have been measured in the composition range between pure NBT and the morphotropic phase boundary included, 0 <= x <= 0.08. The compliance of NBT presents sharp peaks at the rhombohedral/tetragonal and tetragonal/cubic transitions, allowing the determination of the tetragonal region of the phase diagram, up to now impossible due to the strong lattice disorder and small distortions and polarizations involved. In spite of ample evidence of disorder and structural heterogeneity, the R-T transition remains sharp up to x = 0.06, whereas the T-C transition merges into the diffuse and relaxor-like transition associated with broad maxima of the dielectric and elastic susceptibilities. An attempt is made at relating the different features in the anelastic and dielectric curves to different modes of octahedral rotations and polar cation shifts. The possibility is also considered that the cation displacements locally have monoclinic symmetry, as for PZT near the morphotropic phase boundary.Comment: 11 pages, 9 figures, submitted to Phys. Rev.

Proto-planetary disks with CARMA: sub-arsecond observations at millimeter wavelengths

Using the Combined Array for Research in Millimeter-wave Astronomy (CARMA) we observed several proto-planetary disks in the dust continuum emission at 1.3 and 2.8 mm (Isella et al. 2009a, 2009b). The observations have angular resolution between 0.15 and 0.7 arcsecond, corresponding to spatial scales spanning from about the orbit of Saturn up to about the orbital radius of Pluto. The observed disks are characterized by a variety of radial profiles for the dust density. We observe inner disk clearing as well as smooth density profiles, suggesting that disks may form, or evolve, in different ways. Despite that, we find that the characteristic disk radius is correlated with the stellar age increasing from 20 AU to 100 AU over about 5 Myr. Interpreting our results in terms of the temporal evolution of a viscous α-disk, we estimate that (i) at the beginning of the disk evolution about 60% of the circumstellar material was located inside radii of 25-40 AU, (ii) that disks formed with masses from 0.05 to 0.4 solar masses and (iii) that the viscous timescale at the disk initial radius is about 0.1-0.3 Myr. Viscous disk models tightly link the surface density Σ(R) with the radial profile of the disk viscosity ν(R)∝ Rγ. We find values of γ ranging from -0.8 to 0.8, suggesting that the viscosity dependence on the orbital radius can be very different in the observed disks. We demonstrate that the similarity solution for the surface density for γ < 0 can explain the properties of some “transitional” disks without requiring discontinuities in the disk surface density. In the case of LkCa 15, a smooth distribution of material from few stellar radii to about 240 AU can produce both the observed SED and the spatially resolved continuum emission at millimeter wavelengths. For two sources, RY Tau and DG Tau, we observed the dust emission with a resolution as high as 0.15 arcsecond, which corresponds to a spatial scale of 20 AU at the distance of the two stars. The achieved angular resolution is a factor 2 higher than any existing observation of circumstellar disks at the same wavelengths and enable us to investigate the disk structure with unprecedent details. In particular, we present a first attempt to derive the radial profile of the slope of the dust opacity β. We find mean values of β of 0.5 and 0.7 for DG Tau and RY Tau respectively and we exclude that β may vary by more than ±0.4 between 20-70 AU. This implies that the circumstellar dust has a maximum grain size between 10 μm and few centimeters