Information Utility, Reader Interest, Publication Rating and Student Newspaper Readership

This article investigates student motivations for reading a college student paper, including evaluations of performance and content preferences. The declining interest in newspaper readership, particularly among college-age readers has attracted concern among scholars in recent years. In a democracy founded on freedom of the press, fewer than 40% of adults today under the age of 30 subscribe to a paper. This suggests that time spent with newspapers continues to decline even as new media use accounts for the bulk of audience leisure

Factors Affecting Affiliate Station Loyalty Towards Broadcast Television Networks

This article examines factors that may influence the future ties between television networks and their affiliate stations. In particular, it examines affiliate loyalty, or willingness to maintain symbiotic relations with their affiliated network. Due to the sparsity of theories addressing network affiliate relations, several factors were broadly clustered into financial, organizational and programming components and developed as proxy measures to assess network-affiliate ties. Results suggest the importance of network entertainment offerings in the network affiliate relations. Such a finding is consistent with conventional industry wisdom, as entertainment programs bring in compensation as well as a large chunk of local advertising revenues for a station

Exploring Bottled Water Purchase Intention via Trust in Advertising, Product Knowledge, Consumer Beliefs and Theory of Reasoned Action

As the bottled water market is projected to grow continuously worldwide, so is the plastic waste that pollutes the environment. The beverage industry’s marketing campaigns have played an important role in sustaining the popularity of bottled water. Social science theory-based empirical research examining how consumers make bottled water consumption decisions remains limited. To help fill this literature gap, the current study tested a conceptual framework to explore the influence of trust in bottled water advertising and perceived product knowledge on consumer beliefs about bottled water, in conjunction with theory of reasoned action. The study surveyed a sample of college students in the U.S. (N = 445). Findings showed that greater trust in bottled water advertising as well as more false knowledge and less factual knowledge were significantly related to consumer beliefs about bottled water’s product content and image. Furthermore, more favorable cognitive beliefs, affective beliefs, attitude and perceived subjective norms toward bottled water consumption were positively related to purchase intention. To reduce bottled water purchase among young adults, it would be beneficial to utilize marketing strategies to popularize and normalize carrying a reusable water bottle as an environmentally friendly habit and a preferred lifestyle choice

Targeting tauopathy with engineered tau-degrading intrabodies

BACKGROUND: The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies. Recently, immunotherapeutic approaches targeting tau have been demonstrated to be beneficial in decreasing tauopathy in animal models. We previously found that passive immunotherapy with anti-tau antibody to human tau or expression of an anti-tau secreted single-chain variable fragment (scFv) in the central nervous system of a mouse model of tauopathy decreased but did not remove all tau-associated pathology. Although these and other studies demonstrate that conventional immunotherapeutic approaches targeting tau can influence tau pathogenesis, the majority of pathological tau remains in the cytosol of cells, not typically accessible to an extracellular antibody. Therefore, we reasoned targeting intracellular tau might be more efficacious in preventing or decreasing tauopathy. METHODS: By utilizing our anti-tau scFv, we generated anti-tau intrabodies for the expression in the cytosol of neurons. To enhance the degradation capacity of conventional intrabodies, we engineered chimeric anti-tau intrabodies fused to ubiquitin harboring distinct mutations that shuttle intracellular tau for either the proteasome or lysosomal mediated degradation. To evaluate the efficacy in delaying or eliminating tauopathy, we expressed our tau degrading intrabodies or controls in human tau transgenic mice by adeno-associated virus prior to overt tau pathology and after tau deposition. RESULTS: Our results demonstrate, the expression of chimeric anti-tau intrabodies significantly reduce tau protein levels in primary neuronal cultures expression human tau relative to a non-modified anti-tau intrabody. We found the expression of engineered tau-degrading intrabodies destined for proteasomal-mediated degradation are more effective in delaying or eliminating tauopathy than a conventional intrabody in aged human tau transgenic mice. CONCLUSION: This study, harnesses the strength of intrabodies that are amendable for targeting specific domains or modifications with the cell-intrinsic mechanisms that regulate protein degradation providing a new immunotherapeutic approach with potentially improved efficacy

Agenda setting and micro-blog use: An analysis of the relationship between Sina Weibo and newspaper agendas in China

The present study investigates the influence of micro-blogs on the major agenda-setting media in China in the immediate aftermath of a catastrophic railway accident. Study findings are based on a content analysis of micro-blog messages and traditional mainstream media reports that were published in the nine days subsequent to the July 23, 2011 bullet train crash accident. Results suggest that, in the immediate aftermath of a catastrophic train wreck, alternative online media played a decisive role in setting mainstream media agendas and providing a citizen forum on a sensitive issue that their conventional counterparts downplayed, ignored, or missed altogether. In particular, the traditional media’s agenda setting power is no longer universal nor singular within micro-blogging outlets. Instead, traditional media—once a monolithic establishment—are now just one of the role players among many competing influences

Expectations of reward and efficacy guide cognitive control allocation

The amount of mental effort we invest in a task is influenced by the reward we can expect if we perform that task well. However, some of the rewards that have the greatest potential for driving these efforts are partly determined by factors beyond ones control. In such cases, effort has more limited efficacy for obtaining rewards. According to the Expected Value of Control theory, people integrate information about the expected reward and efficacy of task performance to determine the expected value of control, and then adjust their control allocation (i.e., mental effort) accordingly. Here we test this theorys key behavioral and neural predictions. We show that participants invest more cognitive control when this control is more rewarding and more efficacious, and that these incentive components separately modulate EEG signatures of incentive evaluation and proactive control allocation. Our findings support the prediction that people combine expectations of reward and efficacy to determine how much effort to invest

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture

Elevated coexpression of colony-stimulating factor receptor (CSF-1R) and its ligand, CSF-1, correlates with invasiveness and poor prognosis of a variety of epithelial tumors (Kacinski, B.M. 1995. Ann. Med. 27:79–85). Apart from recruitment of macrophages to the tumor site, the mechanisms by which CSF-1 may potentiate invasion are poorly understood. We show that autocrine CSF-1R activation induces hyperproliferation and a profound, progressive disruption of junctional integrity in acinar structures formed by human mammary epithelial cells in three-dimensional culture. Acini coexpressing receptor and ligand exhibit a dramatic relocalization of E-cadherin from the plasma membrane to punctate intracellular vesicles, accompanied by its loss from the Triton-insoluble fraction. Interfering with Src kinase activity, either by pharmacological inhibition or mutation of the Y561 docking site on CSF-1R, prevents E-cadherin translocation, suggesting that CSF-1R disrupts cell adhesion by uncoupling adherens junction complexes from the cytoskeleton and promoting cadherin internalization through a Src-dependent mechanism. These findings provide a mechanistic basis whereby CSF-1R could contribute to invasive progression in epithelial cancers