Geographic representation of East Gippsland, considered endemic for BU as of 2012.

<p>East Gippsland: East of Sale and south of the great divide.</p

The IP for BU infection in the study population.

<p>The IP range (X-axis) for each patient (Y-axis) is demonstrated, arranged from shortest to longest IP. IP range midpoint values are marked as the middle line of each bar.</p

Geographic representation of Bellarine Peninsula, considered endemic for BU as of 2012.

<p>Bellarine Peninsula – east of line from Geelong to Torquay. Mornington and Westernport – southwest of line from Hampton to Tooradin (including Phillip Island).</p

Regions within Eastern Australia defined as endemic for <i>M.ulcerans</i>.

<p>Regions within Eastern Australia defined as endemic for <i>M.ulcerans</i>.</p

The IP according to variables investigated.

<p><b>Abbreviations:</b> Bellarine, Bellarine Peninsula; Mornington, Mornington Peninsula; NT, Northern Territory; NQLD, Northern Queensland; X, median; M, mean; d, days; m, months.</p>a<p><b>Mean</b>: The mean IP for each variable.</p>b<p><b>Range</b>: Shortest and longest incubation period recorded for specific variable,</p

Characteristics of the 23 cases of BU included in the study cohort.

a<p>Three cases had 2 single visit exposures to endemic areas. The causative single visit endemic area exposure was determined via VNTR sequencing.</p>b<p>Clinical presentation was described by patient as the most prominent clinical presentation. Oedematous form was noted in two of the patients with cellulitis.</p

Clinical details for BU patients enrolled in the study.

<p>*STR = WHO recommended treatment of 8 weeks streptomycin and rifampicin;</p>#<p>‘Category’ refers to WHO clinical severity scoring system for BU E = edematous, N = nodule, Q = Plaque, U = ulcerative.</p

Average incubation period in combined cohorts (n = 43) according to variables investigated.

<p>Average incubation period in combined cohorts (n = 43) according to variables investigated.</p

Regions near Melbourne considered endemic for <i>Mycobacterium ulcerans</i>.

<p>Image with adapted text from Trubiano et al. [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006323#pntd.0006323.ref015" target="_blank">15</a>] as per the Creative Commons Attribution license. Small endemic region of East Gippsland not shown, 250km east of Melbourne.</p

Characteristics of 43 cases from Trubiano et al. [15] and current study cohorts.

<p>Characteristics of 43 cases from Trubiano et al. [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006323#pntd.0006323.ref015" target="_blank">15</a>] and current study cohorts.</p