Estruturas de governança corporativa em empresas familiares

O presente trabalho analisa o desenvolvimento histórico e a relevância prática da Governança Corporativa e Familiar nos mercados brasileiros e estrangeiros. Através da revisão de literatura e dos principais códigos de melhores práticas, aponta a importância da aplicação de práticas de Governança Corporativa para fins de viabilizar estruturas societárias justas, transparentes, responsáveis e sustentáveis. Ademais, analisa a relevância dos institutos de Governança Familiar, principalmente em mercados nos quais predomina o controle familiar concentrado. Em vista da relevância econômica das empresas familiares no Brasil, da baixa taxa de continuidade dessas empresas a longo prazo e da escassez de instrumentos legais que disponham sobre o assunto, agentes privados têm empenhado seus melhores esforços no desenvolvimento de práticas capazes de mitigar os conflitos de interesses que comumente levam as operações familiares ao declínio. Portanto, em razão do interesse e da necessidade apresentados pelo mercado a respeito do desenvolvimento de medidas que fomentem a sustentabilidade das empresas, a Governança Corporativa e a Governança Familiar tornam-se a base para a prosperidade das atividades empresariais.This study examines the historical development and the practical relevance of the practices of corporate and family governance in the Brazilian and foreign markets. By reviewing literature and the predominant codes of best practices, it indicates the importance of the application of Corporate Governance practices for the purpose of enabling fair, transparent, accountable and sustainable corporate structures. Moreover, it examines the importance of the Family Governance practices, especially in markets in which family ownership concentration prevails. In view of the economic significance of family businesses in Brazil, of the low long-term survival rate of such companies, and the shortage of legal instruments concerning such matters, private agents have put forth their best efforts to develop practices which may mitigate to conflict of interest which commonly lead family businesses to fail. Thus, as result from the market’s interest and urge in relation to the development of practices which assist the sustainability of companies, Corporate Governance and Family Governance evolve into the foundation for the prosperity of corporate enterprises

Patterns of Positive Selection in Six Mammalian Genomes

Genome-wide scans for positively selected genes (PSGs) in mammals have provided insight into the dynamics of genome evolution, the genetic basis of differences between species, and the functions of individual genes. However, previous scans have been limited in power and accuracy owing to small numbers of available genomes. Here we present the most comprehensive examination of mammalian PSGs to date, using the six high-coverage genome assemblies now available for eutherian mammals. The increased phylogenetic depth of this dataset results in substantially improved statistical power, and permits several new lineage- and clade-specific tests to be applied. Of ∼16,500 human genes with high-confidence orthologs in at least two other species, 400 genes showed significant evidence of positive selection (FDR<0.05), according to a standard likelihood ratio test. An additional 144 genes showed evidence of positive selection on particular lineages or clades. As in previous studies, the identified PSGs were enriched for roles in defense/immunity, chemosensory perception, and reproduction, but enrichments were also evident for more specific functions, such as complement-mediated immunity and taste perception. Several pathways were strongly enriched for PSGs, suggesting possible co-evolution of interacting genes. A novel Bayesian analysis of the possible “selection histories” of each gene indicated that most PSGs have switched multiple times between positive selection and nonselection, suggesting that positive selection is often episodic. A detailed analysis of Affymetrix exon array data indicated that PSGs are expressed at significantly lower levels, and in a more tissue-specific manner, than non-PSGs. Genes that are specifically expressed in the spleen, testes, liver, and breast are significantly enriched for PSGs, but no evidence was found for an enrichment for PSGs among brain-specific genes. This study provides additional evidence for widespread positive selection in mammalian evolution and new genome-wide insights into the functional implications of positive selection.</p

Evaluation of the new modular biogents BG-Pro mosquito trap in comparison to CDC, EVS, BG-Sentinel, and BG-Mosquitaire traps

Mosquito surveillance is an essential component of mosquito control and mosquito traps are a universally employed tool to monitor adult populations. The objective of this paper was to evaluate the new modular Biogents BG-Pro mosquito trap (BGP) and compare its performance to 4 widely used traps for adult mosquitoes: the BG-Sentinel (BGS), the BG Mosquitaire (BGM), the CDC miniature light trap (CDC), and the encephalitis vector survey trap (EVS). One semi-field and 9 field Latin square trials were performed in 7 countries. Results showed that the collection performance of the BGP was equivalent to or exceeded that of the BGS, BGM, CDC, and EVS traps in head-to-head comparisons. The BGP uses 35% less power than the CDC and 75% less than the BGS and BGM. This lower power consumption allows it to run at 5 V for 2 days using a small lightweight 10,000-mAh rechargeable power bank. The BG-Pro is an excellent alternative for the surveillance of mosquito species that are usually monitored with BG-Sentinel, CDC, or EVS traps

Analysis of factors influencing the ultrasonic fetal weight estimation

Objective: The aim of our study was the evaluation of sonographic fetal weight estimation taking into consideration 9 of the most important factors of influence on the precision of the estimation. Methods: We analyzed 820 singleton pregnancies from 22 to 42 weeks of gestational age. We evaluated 9 different factors that potentially influence the precision of sonographic weight estimation ( time interval between estimation and delivery, experts vs. less experienced investigator, fetal gender, gestational age, fetal weight, maternal BMI, amniotic fluid index, presentation of the fetus, location of the placenta). Finally, we compared the results of the fetal weight estimation of the fetuses with poor scanning conditions to those presenting good scanning conditions. Results: Of the 9 evaluated factors that may influence accuracy of fetal weight estimation, only a short interval between sonographic weight estimation and delivery (0-7 vs. 8-14 days) had a statistically significant impact. Conclusion: Of all known factors of influence, only a time interval of more than 7 days between estimation and delivery had a negative impact on the estimation

How managers can build trust in strategic alliances: a meta-analysis on the central trust-building mechanisms

Trust is an important driver of superior alliance performance. Alliance managers are influential in this regard because trust requires active involvement, commitment and the dedicated support of the key actors involved in the strategic alliance. Despite the importance of trust for explaining alliance performance, little effort has been made to systematically investigate the mechanisms that managers can use to purposefully create trust in strategic alliances. We use Parkhe’s (1998b) theoretical framework to derive nine hypotheses that distinguish between process-based, characteristic-based and institutional-based trust-building mechanisms. Our meta-analysis of 64 empirical studies shows that trust is strongly related to alliance performance. Process-based mechanisms are more important for building trust than characteristic- and institutional-based mechanisms. The effects of prior ties and asset specificity are not as strong as expected and the impact of safeguards on trust is not well understood. Overall, theoretical trust research has outpaced empirical research by far and promising opportunities for future empirical research exist

Dialogic data innovations for sustainability transformations and flood resilience: the case for waterproofing data

Extreme weather events are becoming more frequent and have increasing impacts, which disproportionately affect marginalised and impoverished communities. This article proposes and assesses a new methodological approach for developing innovative solutions based on urban data analytics to address sustainability challenges in light of changing climate conditions. The approach draws inspiration from Paulo Freire's dialogic pedagogy and has been implemented in the international transdisciplinary project “Waterproofing Data”, with multiple study sites in Brazil. The project has introduced three methodological interventions: making data practices visible, engaging citizens and communities with data, and sharing data stories. Our study demonstrates that these methods have expanded the types of data used in flood risk management and have engaged a wider range of social groups in the generation, circulation, and utilization of data. We present a framework that provides guidance about the ways in which data innovations can contribute to transformative change, aiming to ensure that future development trajectories are just, inclusive, and equitable. The findings provide evidence that our approach not only helps fill existing data gaps and promote more equitable flood risk governance but also democratises decision-making in climate adaptation. Citizens were empowered to take proactive measures to improve resilience to disaster risks, thereby saving lives and safeguarding livelihoods

Syndecan-1 and FGF-2, but Not FGF Receptor-1, Share a Common Transport Route and Co-Localize with Heparanase in the Nuclei of Mesenchymal Tumor Cells

Syndecan-1 forms complexes with growth factors and their cognate receptors in the cell membrane. We have previously reported a tubulin-mediated translocation of syndecan-1 to the nucleus. The transport route and functional significance of nuclear syndecan-1 is still incompletely understood. Here we investigate the sub-cellular distribution of syndecan-1, FGF-2, FGFR-1 and heparanase in malignant mesenchymal tumor cells, and explore the possibility of their coordinated translocation to the nucleus. To elucidate a structural requirement for this nuclear transport, we have transfected cells with a syndecan-1/EGFP construct or with a short truncated version containing only the tubulin binding RMKKK sequence. The sub-cellular distribution of the EGFP fusion proteins was monitored by fluorescence microscopy. Our data indicate that syndecan-1, FGF-2 and heparanase co-localize in the nucleus, whereas FGFR-1 is enriched mainly in the perinuclear area. Overexpression of syndecan-1 results in increased nuclear accumulation of FGF-2, demonstrating the functional importance of syndecan-1 for this nuclear transport. Interestingly, exogenously added FGF-2 does not follow the route taken by endogenous FGF-2. Furthermore, we prove that the RMKKK sequence of syndecan-1 is necessary and sufficient for nuclear translocation, acting as a nuclear localization signal, and the Arginine residue is vital for this localization. We conclude that syndecan-1 and FGF-2, but not FGFR-1 share a common transport route and co-localize with heparanase in the nucleus, and this transport is mediated by the RMKKK motif in syndecan-1. Our study opens a new perspective in the proteoglycan field and provides more evidence of nuclear interactions of syndecan-1

The role of data in transformations to sustainability : a critical research agenda

This article investigates the role of digital technologies and data innovations, such as big data and citizen-generated data, to enable transformations to sustainability. We reviewed recent literature in this area and identified that the most prevailing assumption of work is related to the capacity of data to inform decision-making and support transformations. However, there is a lack of critical investigation on the concrete pathways for this to happen. We present a framework that identifies scales and potential pathways on how data generation, circulation and usage can enable transformations to sustainability. This framework expands the perspective on the role and functions of data, and it is used to outline a critical research agenda for future work that fully considers the socio-cultural contexts and practices through which data may effectively support transformative pathways to sustainable development

Does personality affect premating isolation between locally-adapted populations?

Background: One aspect of premating isolation between diverging, locally-adapted population pairs is female mate choice for resident over alien male phenotypes. Mating preferences often show considerable individual variation, and whether or not certain individuals are more likely to contribute to population interbreeding remains to be studied. In the Poecilia mexicana-species complex different ecotypes have adapted to hydrogen sulfide (H2S)-toxic springs, and females from adjacent non-sulfidic habitats prefer resident over sulfide-adapted males. We asked if consistent individual differences in behavioral tendencies (animal personality) predict the strength and direction of the mate choice component of premating isolation in this system. Results: We characterized focal females for their personality and found behavioral measures of ‘novel object exploration’, ‘boldness’ and ‘activity in an unknown area’ to be highly repeatable. Furthermore, the interaction term between our measures of exploration and boldness affected focal females’ strength of preference (SOP) for the resident male phenotype in dichotomous association preference tests. High exploration tendencies were coupled with stronger SOPs for resident over alien mating partners in bold, but not shy, females. Shy and/or little explorative females had an increased likelihood of preferring the non-resident phenotype and thus, are more likely to contribute to rare population hybridization. When we offered large vs. small conspecific stimulus males instead, less explorative females showed stronger preferences for large male body size. However, this effect disappeared when the size difference between the stimulus males was small. Conclusions: Our results suggest that personality affects female mate choice in a very nuanced fashion. Hence, population differences in the distribution of personality types could be facilitating or impeding reproductive isolation between diverging populations depending on the study system and the male trait(s) upon which females base their mating decisions, respectively