Means and percent distributions of socioeconomic status indicators and cardiovascular risk factors for the entire sample and by gender.

<p>3C study (France, 1999−2001).</p>*<p>p-value for differences between gender (Kruskall-Wallis test for continuous variables and Chi² test for categorical variables).</p

Associations between socioeconomic status and carotid intima media thickness. Values are differences in carotid intima media thickness measured inµm (95% CI) 3C study (France, 1999−2001).

*<p>p<0.05 **p<0.01.</p><p>All models are adjusted for age and center.</p>a<p>smoking; alcohol intake; body mass index; systolic BP; antihypertensive treatment; diabetes; hypercholesterolemia.</p><p>b Socioeconomic status of the neighborhood measured as the proportion of adults with secondary education.</p

Baseline characteristics of 3C participants.

<p>Baseline characteristics of 3C participants.</p

Cumulative incidence of dementia according to lipid concentrations (triglycerides, HDL-C, LDL-C, total cholesterol).

<p>These graphs are based on age-, sex-, and education-adjusted Cox models (from which indicated <i>p</i>-values were extracted). TG: blue, <1.44 mmol/l (women) or <1.55 mmol/l (men), versus pink, ≥1.44 mmol/l (women) or ≥1.55 mmol/l (men); <i>p</i>-values: <i>p =</i> 0.0046 (all dementia), <i>p =</i> 0.2745 (AD), <i>p =</i> 0.0623 (mixed or vascular dementia). HDL-C: blue, >1.46 mmol/l (women) or >1.20 mmol/l (men), versus pink, ≤1.46 mmol/l (women) or ≤1.20 (men); <i>p</i>-values: <i>p =</i> 0.0528 (all dementia), <i>p =</i> 0.2599 (AD), <i>p =</i> 0.5250 (mixed or vascular dementia). LDL-C: blue, <4.25 mmol/l (women) or <4.00 mmol/l (men), versus pink, ≥4.25 mmol/l (women) or ≥4.00 mmol/l (men); <i>p</i>-values: <i>p =</i> 0.0065 (all dementia), <i>p =</i> 0.0028 (AD), <i>p =</i> 0.5691 (mixed or vascular dementia).TC: blue, <6.60 mmol/l (women) or <6.10 mmol/l (men), versus pink, ≥6.60 mmol/l (women) or ≥6.10 mmol/l (men); <i>p</i>-values: <i>p =</i> 0.0210 (all dementia), <i>p =</i> 0.0383 (AD), <i>p =</i> 0.3259 (mixed or vascular dementia). AD, Alzheimer disease; dem., dementia; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; MoVD, mixed or vascular dementia; TC, total cholesterol; TG, triglycerides.</p

Associations between baseline lipid concentrations and 13-y incident dementia using Cox models.

<p>Associations between baseline lipid concentrations and 13-y incident dementia using Cox models.</p

Baseline characteristics of the 5135 female participants according to their use of hormone treatment.

<p>Baseline characteristics of the 5135 female participants according to their use of hormone treatment.</p

Baseline characteristics of the 5135 female participants according to their mortality status at follow-up.

<p>Baseline characteristics of the 5135 female participants according to their mortality status at follow-up.</p

Cox proportional hazard models for the risk of all-cause deaths according to the use of hormone treatment at baseline.

a<p>Adjusted for age, education, recruitment centre, living situation, incapacities, comorbidity, depressive symptoms and cognitive impairment.</p>b<p>With reference to never users.</p>c<p>113 (89%) used transdermal estradiol treatment and 14 (11%) oral estradiol.</p>d<p>The 27 women who currently used other types of HT were not included in this analysis;</p

Cox proportional hazard models^a for the risk of dying associated with the use of current hormone treatment (versus non-current use) at baseline, stratified by estrogen receptor genotype.

a<p>This analysis was carried out on a sub-population of 4463 women for whom genotyping data was available.</p>b<p>Adjusted for age, education, living status, recruitment centre, incapacities, comorbidity, depressive symptoms and cognitive impairment.</p

Cause of death according to the use of hormone treatment at baseline.

a<p>Unadjusted chi-squared analysis for the difference in the frequency of deaths according to HT use.</p