Negative affective environments improve complex solving performance

Based on recent affect-cognition theories (Bless et al., 1996; Fiedler, 2001; Sinclair, 1988), the present study predicted and showed a differentiated influence of nice and nasty environments on complex problem solving (CPS). Environments were constructed by manipulating the target value ‘capital’ of a complex scenario: Participants in the nice environment (N=42) easily raised the capital and received positive feedback, whereas those in the nasty environment (N=42) hardly enhanced the capital and got negative feedback. The results showed that nasty environments increased negative and decreased positive affect. The reverse was true for nice environments. Furthermore, nasty environments influenced CPS by leading to a higher information retrieval and a better CPS performance. Surprisingly, the influence of environment on CPS was not mediated through affect (cf. Soldat & Sinclair, 2001), as recent affect-cognition theories suggest. The missing influence of affect and the strong impact of environment are discussed

Botanisch-vegetationskundliche Untersuchung der Kernzone Steinkopf im Biosphärenreservat Rhön

Es wurden während der Vegetationsperiode des Jahres 2002 im NSG „Steinkopf“ bei Wüstensachsen botanisch-vegetationskundliche Untersuchungen sowie eine Erhebung biotischer und abiotischer Strukturparameter durchgeführt. Nach Auswertung vorhandener Daten und der Anpassung der Untersuchungsinhalte und -methoden an vorhandene Ergebnisse sowie Untersuchungsziele liegt das Ziel dieser Untersuchungen in der Erarbeitung einer soliden und detaillierten Datengrundlage für faunistische Untersuchungs- und Biomonitoring-Projekte sowie ökologische Umweltbeobachtung und andere ökosystemare Untersuchungen. Die Ergebnisse sollen in Abstimmung mit der Biosphärenreservatsverwaltung, der HLFWW sowie der Naturwaldreservatsforschung im Senckenberg-Institut benutzerorientiert dargestellt werden

Optimization as an analysis tool for human complex decision making

We present a problem class of mixed-integer nonlinear programs (MINLPs) with nonconvex continuous relaxations which stem from economic test scenarios that are used in the analysis of human complex problem solving. In a round-based scenario participants hold an executive function. A posteriori a performance indicator is calculated and correlated to personal measures such as intelligence, working memory, or emotion regulation. Altogether, we investigate 2088 optimization problems that differ in size and initial conditions, based on real-world experimental data from 12 rounds of 174 participants. The goals are twofold. First, from the optimal solutions we gain additional insight into a complex system, which facilitates the analysis of a participant’s performance in the test. Second, we propose a methodology to automatize this process by providing a new criterion based on the solution of a series of optimization problems. By providing a mathematical optimization model and this methodology, we disprove the assumption that the “fruit fly of complex problem solving,” the Tailorshop scenario that has been used for dozens of published studies, is not mathematically accessible—although it turns out to be extremely challenging even for advanced state-of-the-art global optimization algorithms and we were not able to solve all instances to global optimality in reasonable time in this study. The publicly available computational tool Tobago [TOBAGO web site https://sourceforge.net/projects/tobago] can be used to automatically generate problem instances of various complexity, contains interfaces to AMPL and GAMS, and is hence ideally suited as a testbed for different kinds of algorithms and solvers. Computational practice is reported with respect to the influence of integer variables, problem dimension, and local versus global optimization with different optimization codes

Resequencing of VAX1 in patients with nonsyndromic cleft lip with or without cleft palate

BACKGROUND: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common of all congenital anomalies, and has a multifactorial etiology involving both environmental and genetic factors. Recent genome-wide association studies (GWAS) identified strong association between a locus on chromosome 10q25.3 and NSCL/P in European samples. One gene at 10q25.3, the ventral anterior homeobox 1 (VAX1) gene, is considered a strong candidate gene for craniofacial malformations. The purpose of the present study was to provide further evidence that VAX1 is the causal gene at the 10q25.3 locus through identification of an excess of rare mutations in patients with NSCL/P. METHODS: The 5'UTR, complete coding regions, and adjacent splice sites of the two known VAX1 isoforms were sequenced in 384 patients with NSCL/P and 384 controls of Central European descent. Observed variants were investigated with respect to familial cosegregation or de novo occurrence, and in silico analyses were performed to identify putative effects on the transcript or protein level. RESULTS: Eighteen single-base variants were found, 15 of them rare and previously unreported. In the long VAX1 isoform, predicted functionally relevant variants were observed more often in NSCL/P cases, although this difference was not significant (p = 0.17). Analysis of family members demonstrated incomplete cosegregation in most pedigrees. CONCLUSION: Our data do not support the hypothesis that highly penetrant rare variants in VAX1 are a cause of NSCL/P. To determine whether VAX1 is the causative gene at 10q25.3 further research, in particular into the biologic function of its long isoform, is warranted. Birth Defects Research (Part A), 2012. (c) 2012 Wiley Periodicals, Inc