329 research outputs found
Measurement of the hyperfine coupling constants and absolute energies of the and levels in atomic cesium
We report measurements of the hyperfine coupling constant for the $8p \
^2P_{1/2}^{133}\simA = 42.933 \: (8)8p
\ ^2P_{3/2}8p \
^2P_{1/2}8p \ ^2P_{3/2}$ states of cesium.Comment: 8 pages, 7 figures, 5 table
Advances in Hyaluronan Biology: Signaling, Regulation, and Disease Mechanisms
Hyaluronan is an extracellular glycosaminoglycan polymer consisting of linear disaccharide units containing alternating glucuronate and N-acetylglucosamine.Many cell types make hyaluronan, which unlike most other macromolecules is assembled at the plasmamembrane and concurrently translocated through the hyaluronan synthase enzyme. The normal function of large hyaluronan polymers (\u3e1MDa) in tissue cushioning, hydration, and lubrication is well established. The aberrant accumulation and degradation of hyaluronan and the receptor-mediated signaling of smaller hyaluronan fragments have also been extensively implicated in a variety of pathological states including inflammation and cancer. More recently, the discovery that hyaluronan can either be a structural matrix component or appear as smaller processed polymers and oligomers that differentially engage a diverse range of signaling receptors has created an exciting paradigm shift and reenergized hyaluronan research in a broad range of fields. In this special issue, eight review articles focus on summarizing the latest contributions to understanding hyaluronan synthesis and catabolism and the regulation of hyaluronan functions. Seven novel primary research articles also investigate multiple roles of hyaluronan in disease progression and targeting
The Ursinus Weekly, November 24, 1958
Y holds seminar Nov. 19; Marriage problem is topic ⢠Fireside chats to be held Dec. 3 at prof\u27s home ⢠C. Carpenter has poem published in anthology ⢠Administrative regulation ⢠Mayes, Francis \u2762 representatives to MSGA ⢠New pledges announced by Alpha Psi Omega ⢠De Gaulle and France topic at second Forum of Fall semester ⢠Who\u27s who honors 12 leading Ursinus seniors ⢠Senior Ball to be held at Sunnybrook Dec. 5 ⢠W.S.G.A. presents plaque to winning frosh team ⢠Editorial: Thanksgiving ⢠Letters to the editor ⢠Review: Joan of Lorraine ⢠Slightly allegorical ⢠U.C. soccermen lose last three games; Finish 2-6-1 ⢠Prospects for U.C. basketball team looking up ⢠Varsity hockey finishes with 4-2-1; J.V. is 6-0-1 ⢠Football squad drops two games 12-0, 34-6 ⢠Sorority bids ⢠American hist. students begin tour program ⢠Fine art of datinghttps://digitalcommons.ursinus.edu/weekly/1372/thumbnail.jp
Phase I dose escalation study of vinorelbine and topotecan combination chemotherapy in patients with recurrent lung cancer
Costâeffectiveness of realâworld administration of tobacco pharmacotherapy in the United States Veterans Health Administration
Background and aimsCostâeffectiveness studies in randomized clinical trials have shown that tobacco cessation pharmacotherapy is among the most costâeffective of healthâcare interventions. Clinical trial eligibility criteria and treatment protocols may not be followed in actual practice. This study aimed to determine whether tobacco cessation pharmacotherapy is costâeffective in realâworld settings.DesignA retrospective analysis of costs and outcomes.SettingHospitals and clinics of the US Veterans Health Administration, USA.ParticipantsA total of 589â862 US veterans who screened positive for tobacco use in 2011.Intervention and comparatorTobacco users who initiated smoking cessation pharmacotherapy in the 6Â months after screening were compared with those who did not use pharmacotherapy in this period. Pharmacotherapy included nicotine replacement therapy, bupropion (if prescribed at 300Â mg per day or specifically for tobacco cessation) or varenicline.MeasuresEffectiveness was determined from responses to a subsequent tobacco screening conducted between 7 and 18Â months after the treatment observation period. Cost of medications and prescribing healthâcare encounters was determined for the period between initial and followâup tobacco use screening. Multivariate fixedâeffects regression was used to assess the effect of initial treatment status on cost and outcome while controlling for differences in caseâmix with propensity weighting to adjust for confounding by indication.FindingsThirteen per cent of participants received tobacco cessation pharmacotherapy within 6Â months of initial screening. After an average of an additional 218.1Â daysâ followâup, those who initially received pharmacotherapy incurred 4705 per quit. The upper limit of the 99.9% confidence region was 7144 per quit, with the upper limit of the 99.9% confidence region 4705 per quit.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150598/1/add14621_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150598/2/add14621.pd
Advances in Hyaluronan Biology: Signaling, Regulation, and Disease Mechanisms
Hyaluronan is an extracellular glycosaminoglycan polymer consisting of linear disaccharide units containing alternating glucuronate and N-acetylglucosamine.Many cell types make hyaluronan, which unlike most other macromolecules is assembled at the plasmamembrane and concurrently translocated through the hyaluronan synthase enzyme. The normal function of large hyaluronan polymers (\u3e1MDa) in tissue cushioning, hydration, and lubrication is well established. The aberrant accumulation and degradation of hyaluronan and the receptor-mediated signaling of smaller hyaluronan fragments have also been extensively implicated in a variety of pathological states including inflammation and cancer. More recently, the discovery that hyaluronan can either be a structural matrix component or appear as smaller processed polymers and oligomers that differentially engage a diverse range of signaling receptors has created an exciting paradigm shift and reenergized hyaluronan research in a broad range of fields. In this special issue, eight review articles focus on summarizing the latest contributions to understanding hyaluronan synthesis and catabolism and the regulation of hyaluronan functions. Seven novel primary research articles also investigate multiple roles of hyaluronan in disease progression and targeting
Transtheoretical Model-based multiple behavior intervention for weight management: Effectiveness on a population basis
Background: The increasing prevalence of overweight and obesity underscores the need for evidence-based, easily disseminable interventions for weight management that can be delivered on a population basis. The Transtheoretical Model (TTM) offers a promising theoretical framework for multiple behavior weight management interventions.
Methods: Overweight or obese adults (BMI 25â39.9; n = 1277) were randomized to no-treatment control or home-based, stage-matched multiple behavior interventions for up to three behaviors related to weight management at 0, 3, 6, and 9 months. All participants were re-assessed at 6, 12, and 24 months.
Results: Significant treatment effects were found for healthy eating (47.5% versus 34.3%), exercise (44.90% versus 38.10%), managing emotional distress (49.7% versus 30.30%), and untreated fruit and vegetable intake (48.5% versus 39.0%) progressing to Action/Maintenance at 24 months. The groups differed on weight lost at 24 months. Co-variation of behavior change occurred and was much more pronounced in the treatment group, where individuals progressing to Action/Maintenance for a single behavior were 2.5â5 times more likely to make progress on another behavior. The impact of the multiple behavior intervention was more than three times that of single behavior interventions.
Conclusions: This study demonstrates the ability of TTM-based tailored feedback to improve healthy eating, exercise, managing emotional distress, and weight on a population basis. The treatment produced a high level of population impact that future multiple behavior interventions can seek to surpass
Progressive regression of left ventricular hypertrophy two years after bariatric surgery.
BACKGROUND: Obesity is a systemic disorder associated with an increase in left ventricular mass and premature death and disability from cardiovascular disease. Although bariatric surgery reverses many of the hormonal and hemodynamic derangements, the long-term collective effects on body composition and left ventricular mass have not been considered before. We hypothesized that the decrease in fat mass and lean mass after weight loss surgery is associated with a decrease in left ventricular mass.
METHODS: Fifteen severely obese women (mean body mass index [BMI]: 46.7+/-1.7 kg/m(2)) with medically controlled hypertension underwent bariatric surgery. Left ventricular mass and plasma markers of systemic metabolism, together with body mass index (BMI), waist and hip circumferences, body composition (fat mass and lean mass), and resting energy expenditure were measured at 0, 3, 9, 12, and 24 months.
RESULTS: Left ventricular mass continued to decrease linearly over the entire period of observation, while rates of weight loss, loss of lean mass, loss of fat mass, and resting energy expenditure all plateaued at 9 [corrected] months (P \u3c.001 for all). Parameters of systemic metabolism normalized by 9 months, and showed no further change at 24 months after surgery.
CONCLUSIONS: Even though parameters of obesity, including BMI and body composition, plateau, the benefits of bariatric surgery on systemic metabolism and left ventricular mass are sustained. We propose that the progressive decrease of left ventricular mass after weight loss surgery is regulated by neurohumoral factors, and may contribute to improved long-term survival
Exploring the dynamics of compliance with community penalties
In this paper, we examine how compliance with community penalties has been theorized hitherto and seek to develop a new dynamic model of compliance with community penalties. This new model is developed by exploring some of the interfaces between existing criminological and socio-legal work on compliance. The first part of the paper examines the possible definitions and dimensions of compliance with community supervision. Secondly, we examine existing work on explanations of compliance with community penalties, supplementing this by drawing on recent socio-legal scholarship on private individualsâ compliance with tax regimes. In the third part of the paper, we propose a dynamic model of compliance, based on the integration of these two related analyses. Finally, we consider some of the implications of our model for policy and practice
concerning community penalties, suggesting the need to move
beyond approaches which, we argue, suffer from compliance myopia; that is, a short-sighted and narrowly focused view of the issues
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