Particle Dark Energy

We explore the physics of a gas of particles interacting with a condensate that spontaneously breaks Lorentz invariance. The equation of state of this gas varies from 1/3 to less than -1 and can lead to the observed cosmic acceleration. The particles are always stable. In our particular class of models these particles are fermions with a chiral coupling to the condensate. They may behave as relativistic matter at early times, produce a brief period where they dominate the expansion with w<0 today, and behave as matter at late time. There are no small parameters in our models, which generically lead to dark energy clustering and, depending on the choice of parameters, smoothing of small scale power.Comment: 8 pages, 5 figures; minor update with added refs; version appearing in Phys. Rev.

Injection-Locked Dye Laser Pumped By A Xenon-lon Laser

Injection locking of a dye laser is reported for a 4-minor ring-cavity dye User pumped by a xenon-ion laser. Both a He-Ne laser and tunable CW dye laser were used as the injection sources. Copyright © 1980 by The Institute of Electrical and Electronics Engineers, Inc

Speckle Interferometry of Metal-Poor Stars in the Solar Neighborhood. I

We report the results of speckle-interferometric observations of 109 high proper-motion metal-poor stars made with the 6-m telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences. We resolve eight objects -- G102-20, G191-55, BD+19$^\circ$~1185A, G89-14, G87-45, G87-47, G111-38, and G114-25 -- into individual components and we are the first to astrometrically resolve seven of these stars. New resolved systems included two triple (G111-38, G87-47) and one quadruple (G89-14) star. The ratio of single-to-binary-to-triple-to-quadruple systems among the stars of our sample is equal to 71:28:6:1.Comment: 8 pages, 4 figures, accepted to Astrophysical Bulleti

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

Caseinolytic peptidase P (ClpP), a double-ring peptidase with 14 subunits, collaborates with ATPases associated with diverse activities (AAA+) partners to execute ATP-dependent protein degradation. Although many ClpP enzymes self-assemble into catalytically active homo-tetradecamers able to cleave small peptides, the Mycobacterium tuberculosis enzyme consists of discrete ClpP1 and ClpP2 heptamers that require a AAA+ partner and protein–substrate delivery or a peptide agonist to stabilize assembly of the active tetradecamer. Here, we show that cyclic acyldepsipeptides (ADEPs) and agonist peptides synergistically activate ClpP1P2 by mimicking AAA + partners and substrates, respectively, and determine the structure of the activated complex. Our studies establish the basis of heteromeric ClpP1P2 assembly and function, reveal tight coupling between the conformations of each ring, show that ADEPs bind only to one ring but appear to open the axial pores of both rings, provide a foundation for rational drug development, and suggest strategies for studying the roles of individual ClpP1 and ClpP2 rings in Clp-family proteolysisNational Institutes of Health (U.S.) (NIH Grant GM-101988)Brown UniversityNational Science Foundation (U.S.) (CAREER award)National Institute of General Medical Sciences (U.S.) (Grant P41 GM103403)United States. Dept. of Energy (Contract DE-AC02-06CH11357

Blue Horizontal Branch Stars in Old, Metal-Rich Stellar Systems

Twenty years ago, Burstein et al. (1984)suggested that strong CN and Hbeta absorption meant younger ages among globular clusters in the Andromeda galaxy (M31), unless blue stars above the main-sequence turnoff or on the horizontal branch were uncommonly prominent. Here we test these suggestions by fitting the detailed mid-ultraviolet (2280-3120A) and optical (3850-4750A) spectra of one moderately metal-rich M31 globular cluster, G1. We explore the effects of a wide range of non-solar temperatures and abundance ratios, by combining a small set of theoretical stellar spectra like those of Peterson et al. (2001) that were calculated using extensively updated atomic-line constants. To match the mid-UV fluxes of G1, we find that hot components with Teff >= 8000K must be included. We obtain a very good fit with cool and hot blue horizontal branch (BHB) stars, but less satisfactory fits for blue straggler stars, those hotter than the main-sequence turnoff. The G1 color-magnitude diagram does show cool BHB stars, and the color of its giant branch supports the metallicity of one-sixth the solar value that we deduce. The turnoff temperature of the best-fit model is consistent with that of turnoff stars in galactic globular clusters and the field halo, indicating G1 is comparably old. Because metal-rich cool BHB and extremely blue HB stars have now been found within our own Galaxy, we suggest that these hot horizontal-branch stars be considered in fitting spectra of metal-rich populations such as the Andromeda globular clusters, to avoid possible underestimates of their ages. We plan to make the relevant spectral calculations available as part of our Hubble Treasury Program

Line Broadening in Field Metal-poor Red Giant and Red Horizontal Branch Stars

We report 349 radial velocities for 45 metal-poor field red giant and red horizontal branch stars. We have have identified one new spectroscopic binary, HD 4306, and one possible such system, HD 184711. We also report 57 radial velocities for 11 of the 91 stars reported on previously by Carney et al. (2003). As was found in the previous study, radial velocity "jitter" is present in many of the most luminous stars. Excluding stars showing spectroscopic binary orbital motion, all 7 of the red giants with M(V) <= -2.0 display jitter, as well as 3 of the 14 stars with -2.0 <= M(V) <= -1.4. We have also measured line broadening in all of the new spectra, using synthetic spectra as templates. The most luminous red giants show significant line broadening, as do many of the red horizontal branch stars, and we discuss briefly possible causes.Comment: To appear in the Astronomical Journa

Rubidium and lead abundances in giant stars of the globular clusters M4 and M5

We present measurements of the neutron-capture elements Rb and Pb for bright giants in the globular clusters M4 and M5. The clusters are of similar metallicity ([Fe/H] = -1.2) but M4 is decidedly s-process enriched relative to M5: [Ba/Fe] = +0.6 for M4 but 0.0 for M5. The Rb and Pb abundances were derived by comparing synthetic spectra with high-resolution, high signal-to-noise ratio spectra obtained with MIKE on the Magellan telescope. Abundances of Y, Zr, La, and Eu were also obtained. In M4, the mean abundances from 12 giants are [Rb/Fe] = 0.39 +/- 0.02 (sigma = 0.07), [Rb/Zr] = 0.17 +/- 0.03 (sigma = 0.08), and [Pb/Fe] = 0.30 +/- 0.02 (sigma = 0.07). In M5, the mean abundances from two giants are [Rb/Fe] = 0.00 +/- 0.05 (sigma = 0.06), [Rb/Zr] = 0.08 +/- 0.08 (sigma = 0.11), and [Pb/Fe] = -0.35 +/- 0.02 (sigma = 0.04). Within the measurement uncertainties, the abundance ratios [Rb/Fe], [Pb/Fe] and [Rb/X] for X = Y, Zr, La are constant from star-to-star in each cluster and none of these ratios are correlated with O or Na abundances. While M4 has a higher Rb abundance than M5, the ratios [Rb/X] are similar in both clusters indicating that the nature of the s-products are very similar for each cluster but the gas from which M4's stars formed had a higher concentration of these products.Comment: Accepted for publication in Ap

The rotational velocity of the rapidly oscillating AP star HD 83368

A rotational velocity υrotsini=33±3km s−1 has been measured for the Ap star HD 83368, confirming the prediction of 32 km s−1 (Kurtz) from an ‘oblique pulsator’ model

Restriction of the Conformational Dynamics of the Cyclic Acyldepsipeptide Antibiotics Improves Their Antibacterial Activity

The cyclic acyldepsipeptide (ADEP) antibiotics are a new class of antibacterial agents that kill bacteria via a mechanism that is distinct from all clinically used drugs. These molecules bind and dysregulate the activity of the ClpP peptidase. The potential of these antibiotics as antibacterial drugs has been enhanced by the elimination of pharmacological liabilities through medicinal chemistry efforts. Here, we demonstrate that the ADEP conformation observed in the ADEP–ClpP crystal structure is fortified by transannular hydrogen bonding and can be further stabilized by judicious replacement of constituent amino acids within the peptidolactone core structure with more conformationally constrained counterparts. Evidence supporting constraint of the molecule into the bioactive conformer was obtained by measurements of deuterium-exchange kinetics of hydrogens that were proposed to be engaged in transannular hydrogen bonds. We show that the rigidified ADEP analogs bind and activate ClpP at lower concentrations in vitro. Remarkably, these compounds have up to 1200-fold enhanced antibacterial activity when compared to those with the peptidolactone core structure common to two ADEP natural products. This study compellingly demonstrates how rational modulation of conformational dynamics may be used to improve the bioactivities of natural products.National Science Foundation (U.S.) (NSF CAREER Award)Brown UniversityNational Institutes of Health (U.S.) (NIH Grant GM-101988