Is Apremilast (Otezla) Effective in Reducing Pruritus in Adults over 18 Years Old with Plaque Psoriasis?

OBJECTIVE: The objective of this selective EBM review is to determine whether or not apremilast (Otezla) is effective in reducing pruritus in adults over 18 years old with plaque psoriasis STUDY DESIGN: This review is based on three randomized controlled trials (RCTs) published in 2012, and 2015. DATA SOURCES: Three randomized controlled trials comparing the effectiveness of apremilast to a placebo in reducing pruritus in adults over 18 years old with plaque psoriasis, found using PubMed. OUTCOMES MEASURED: The outcome studied was improvement of the psoriatic plaques based on reduction in pruritus measured by the Pruritus Visual Analogue Scale (VAS) score and Psoriasis Area and Severity Index (PASI) score. RESULTS: Papp et al. (2012) showed a significant reduction in pruritus while using 30 mg of apremilast BID (p\u3c0.0004). The study by Papp et al. (2015) showed that apremilast resulted in a significantly greater improvement compared to placebo, in reducing pruritus (p\u3c0.0001). The study by Paul et al. displayed significant improvements in pruritus when compared to the placebo (p\u3c0.001) CONCLUSIONS: Results of all three studies demonstrate that 30mg of apremilist BID is effective in reducing pruritus in adults with plaque psoriasis. Each study showed improvement of pruritus with minimal side effects

What Happens When Insurers Make Insurance Laws? State Legislative Agendas and the Occupational Makeup of Government

Do the occupational backgrounds of politicians affect the government’s agenda? Businesses have long thought so. The first occupational data on state legislators were collected by the Insurance Information Institute, an interest group representing major insurance companies. In this paper, we test one potential motive for these kinds of efforts: the idea that the occupational makeup of governments affects the agendas they pursue, an argument that has been largely neglected in research on politicians’ occupational backgrounds. We focus here on the insurance industry. Using original data, we find that state legislatures with more former insurers consider fewer bills regulating insurance (negative agenda control), that former insurers play a disproportionate role in drafting the insurance bills that are introduced (positive agenda control), and that the bills former insurers introduce tend to be more favorable to the industry than those that their colleagues introduce (positive agenda control). The occupational makeup of legislatures may indeed affect their agendas, as industry groups have long suspected

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers.

Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine. To realize this potential, however, targeted nanocarriers must simultaneously overcome multiple challenges, including specificity, stability and a high capacity for disparate cargos. Here we report porous nanoparticle-supported lipid bilayers (protocells) that synergistically combine properties of liposomes and nanoporous particles. Protocells modified with a targeting peptide that binds to human hepatocellular carcinoma exhibit a 10,000-fold greater affinity for human hepatocellular carcinoma than for hepatocytes, endothelial cells or immune cells. Furthermore, protocells can be loaded with combinations of therapeutic (drugs, small interfering RNA and toxins) and diagnostic (quantum dots) agents and modified to promote endosomal escape and nuclear accumulation of selected cargos. The enormous capacity of the high-surface-area nanoporous core combined with the enhanced targeting efficacy enabled by the fluid supported lipid bilayer enable a single protocell loaded with a drug cocktail to kill a drug-resistant human hepatocellular carcinoma cell, representing a 10(6)-fold improvement over comparable liposomes

Technology, time and transition in higher education : two different realities of everyday Facebook use in the first year of university in the UK.

Within the range of websites and apps that are part of first-year undergraduates’ digital environments, the social network site Facebook is perhaps the most popular and prominent. As such, the ubiquitous nature of Facebook in the higher education landscape has drawn much attention from scholars. Drawing on data from a longitudinal connective ethnography, this paper uses two ethnographic stories to explore further the realities of social media usage by newly enrolled undergraduate students in a UK university. These ethnographic stories tell two differing tales - one of connection, intent, use and organisation - the other, of disconnection, disengagement and unrealised expectations. Facebook structures students’ time at university both through connection and disconnection practices and examples of these are presented under two headings ‘I’m always on it’ and ‘Being academic’. First-year student experiences of Higher Education and social media use are not uniform, but nuanced and responsive to their specific ecosocial systems