Educating Souls, Selves, or Minds?

ABSTRACT Margaret Carmody: Educating Souls, Selves, or Minds? (Under the direction of Madeleine Grumet) At the beginning of the twentieth century, the term “soul” was virtually deleted from curriculum theory and replaced with the categories of “self” and “mind” from the learning sciences. This dissertation is a hermeneutic study undertaken to explore inviting the term back as a structuring concept in curriculum theory without privileging specific religious beliefs and to address those aesthetic, subjective, moral, and somatic dimensions of human experience that often do not get addressed in curricula focused on minds and selves. I explore how a fusion of Waldorf School founder Rudolf Steiner’s theory of soul, Waldorf curriculum theory, psychotherapist Mari Ruti’s theory of a post-humanist soul, and philosopher Kieran Egan’s curriculum theory may provide a new horizon to which curriculum theory may direct its efforts to educate human beings to be more open to what is unknown and learn to respond to difference in caring, creative, and conscious ways. Keywords: Soul, Rudolf Steiner, Mari Ruti, Kieran Egan, Elementary School Curriculum Theory, Waldorf Education.Doctor of Philosoph

The Medical Action Ontology: A tool for annotating and analyzing treatments and clinical management of human disease.

BACKGROUND: Navigating the clinical literature to determine the optimal clinical management for rare diseases presents significant challenges. We introduce the Medical Action Ontology (MAxO), an ontology specifically designed to organize medical procedures, therapies, and interventions. METHODS: MAxO incorporates logical structures that link MAxO terms to numerous other ontologies within the OBO Foundry. Term development involves a blend of manual and semi-automated processes. Additionally, we have generated annotations detailing diagnostic modalities for specific phenotypic abnormalities defined by the Human Phenotype Ontology (HPO). We introduce a web application, POET, that facilitates MAxO annotations for specific medical actions for diseases using the Mondo Disease Ontology. FINDINGS: MAxO encompasses 1,757 terms spanning a wide range of biomedical domains, from human anatomy and investigations to the chemical and protein entities involved in biological processes. These terms annotate phenotypic features associated with specific disease (using HPO and Mondo). Presently, there are over 16,000 MAxO diagnostic annotations that target HPO terms. Through POET, we have created 413 MAxO annotations specifying treatments for 189 rare diseases. CONCLUSIONS: MAxO offers a computational representation of treatments and other actions taken for the clinical management of patients. Its development is closely coupled to Mondo and HPO, broadening the scope of our computational modeling of diseases and phenotypic features. We invite the community to contribute disease annotations using POET (https://poet.jax.org/). MAxO is available under the open-source CC-BY 4.0 license (https://github.com/monarch-initiative/MAxO). FUNDING: NHGRI 1U24HG011449-01A1 and NHGRI 5RM1HG010860-04

Introducing BASE: the Biomes of Australian Soil Environments soil microbial diversity database

Background: Microbial inhabitants of soils are important to ecosystem and planetary functions, yet there are large gaps in our knowledge of their diversity and ecology. The 'Biomes of Australian Soil Environments' (BASE) project has generated a database of microbial diversity with associated metadata across extensive environmental gradients at continental scale. As the characterisation of microbes rapidly expands, the BASE database provides an evolving platform for interrogating and integrating microbial diversity and function. Findings: BASE currently provides amplicon sequences and associated contextual data for over 900 sites encompassing all Australian states and territories, a wide variety of bioregions, vegetation and land-use types. Amplicons target bacteria, archaea and general and fungal-specific eukaryotes. The growing database will soon include metagenomics data. Data are provided in both raw sequence (FASTQ) and analysed OTU table formats and are accessed via the project's data portal, which provides a user-friendly search tool to quickly identify samples of interest. Processed data can be visually interrogated and intersected with other Australian diversity and environmental data using tools developed by the 'Atlas of Living Australia'. Conclusions: Developed within an open data framework, the BASE project is the first Australian soil microbial diversity database. The database will grow and link to other global efforts to explore microbial, plant, animal, and marine biodiversity. Its design and open access nature ensures that BASE will evolve as a valuable tool for documenting an often overlooked component of biodiversity and the many microbe-driven processes that are essential to sustain soil function and ecosystem services

Introducing BASE: the Biomes of Australian Soil Environments soil microbial diversity database

Microbial inhabitants of soils are important to ecosystem and planetary functions, yet there are large gaps in our knowledge of their diversity and ecology. The ‘Biomes of Australian Soil Environments’ (BASE) project has generated a database of microbial diversity with associated metadata across extensive environmental gradients at continental scale. As the characterisation of microbes rapidly expands, the BASE database provides an evolving platform for interrogating and integrating microbial diversity and function

Introducing BASE: the Biomes of Australian Soil Environments soil microbial diversity database

Corrected by: Erratum: Introducing BASE: The Biomes of Australian Soil Environments soil microbial diversity database [GigaScience. 5, 1, (2016) (1-11)] DOI: 10.1186/s13742-016-0126-5. In GigaScience 6(5):1, the authorship list should have included Leon Court, who was responsible for sample collection and preparation, sampling design and sequencing method design. The authors regret this omission.BACKGROUND Microbial inhabitants of soils are important to ecosystem and planetary functions, yet there are large gaps in our knowledge of their diversity and ecology. The ‘Biomes of Australian Soil Environments’ (BASE) project has generated a database of microbial diversity with associated metadata across extensive environmental gradients at continental scale. As the characterisation of microbes rapidly expands, the BASE database provides an evolving platform for interrogating and integrating microbial diversity and function. FINDINGS BASE currently provides amplicon sequences and associated contextual data for over 900 sites encompassing all Australian states and territories, a wide variety of bioregions, vegetation and land-use types. Amplicons target bacteria, archaea and general and fungal-specific eukaryotes. The growing database will soon include metagenomics data. Data are provided in both raw sequence (FASTQ) and analysed OTU table formats and are accessed via the project’s data portal, which provides a user-friendly search tool to quickly identify samples of interest. Processed data can be visually interrogated and intersected with other Australian diversity and environmental data using tools developed by the ‘Atlas of Living Australia’. CONCLUSIONS Developed within an open data framework, the BASE project is the first Australian soil microbial diversity database. The database will grow and link to other global efforts to explore microbial, plant, animal, and marine biodiversity. Its design and open access nature ensures that BASE will evolve as a valuable tool for documenting an often overlooked component of biodiversity and the many microbe-driven processes that are essential to sustain soil function and ecosystem services.Andrew Bissett, Anna Fitzgerald, Thys Meintjes, Pauline M. Mele, Frank Reith, Paul G. Dennis, Martin F. Breed, Belinda Brown, Mark V. Brown, Joel Brugger, Margaret Byrne, Stefan Caddy-Retalic, Bernie Carmody, David J. Coates, Carolina Correa, Belinda C. Ferrari, Vadakattu V. S. R. Gupta, Kelly Hamonts, Asha Haslem, Philip Hugenholtz, Mirko Karan, Jason Koval, Andrew J. Lowe, Stuart Macdonald, Leanne McGrath, David Martin, Matt Morgan, Kristin I. North, Chanyarat Paungfoo-Lonhienne, Elise Pendall, Lori Phillips, Rebecca Pirzl, Jeff R. Powell, Mark A. Ragan, Susanne Schmidt, Nicole Seymour, Ian Snape, John R. Stephen, Matthew Stevens, Matt Tinning, Kristen Williams, Yun Kit Yeoh, Carla M. Zammit, and Andrew Youn

Associations between depressive symptoms and disease progression in older patients with chronic kidney disease: results of the EQUAL study

Background Depressive symptoms are associated with adverse clinical outcomes in patients with end-stage kidney disease; however, few small studies have examined this association in patients with earlier phases of chronic kidney disease (CKD). We studied associations between baseline depressive symptoms and clinical outcomes in older patients with advanced CKD and examined whether these associations differed depending on sex. Methods CKD patients (>= 65 years; estimated glomerular filtration rate <= 20 mL/min/1.73 m(2)) were included from a European multicentre prospective cohort between 2012 and 2019. Depressive symptoms were measured by the five-item Mental Health Inventory (cut-off <= 70; 0-100 scale). Cox proportional hazard analysis was used to study associations between depressive symptoms and time to dialysis initiation, all-cause mortality and these outcomes combined. A joint model was used to study the association between depressive symptoms and kidney function over time. Analyses were adjusted for potential baseline confounders. Results Overall kidney function decline in 1326 patients was -0.12 mL/min/1.73 m(2)/month. A total of 515 patients showed depressive symptoms. No significant association was found between depressive symptoms and kidney function over time (P = 0.08). Unlike women, men with depressive symptoms had an increased mortality rate compared with those without symptoms [adjusted hazard ratio 1.41 (95% confidence interval 1.03-1.93)]. Depressive symptoms were not significantly associated with a higher hazard of dialysis initiation, or with the combined outcome (i.e. dialysis initiation and all-cause mortality). Conclusions There was no significant association between depressive symptoms at baseline and decline in kidney function over time in older patients with advanced CKD. Depressive symptoms at baseline were associated with a higher mortality rate in men

The Private Use of Public Power: The Private University and the Power of Eminent Domain

The study which follows attempts to trace, in a necessarily limited fashion, the evolving use of eminent domain on behalf of private interest groups throughout the last century and a half of American legal history. Part One of the study traces the broadening scope of eminent domain in the United States during the 19th and 20th centuries, focusing on the direct use of eminent domain by private interest groups as a key element in the increasing breadth of the power. Part Two delineates the process whereby one modern private interest group-an informal aggregation of American colleges and universities-succeeded in acquiring access to the states\u27power of eminent domain through Section 112 of the federal urban renewal program. Although Section 112 has received surprisingly little attention from students of the urban renewal program, within ten years of its inception the statute had been used to generate three quarters of a billion dollars worth of federal matching money for participating communities and to acquire thousands of acres of privately owned urban land for university expansion.\u27 Part Three of the present work seeks to trace the process whereby the city of Nashville, Tennessee, sought to participate in just such a Section 112 urban renewal project. The case study of Nashville\u27s experience with Section 112 focuses upon the process by which one community resolved to commit its power of eminent domain to assist the expansion of a private university and the tensions within the community produced by that decision. Although Nashville\u27s experience with Section 112 is by no means necessarily typical of those of the hundreds of other cities that participated in the program, it would seem to indicate that in at least one community, the federal urban renewal process combined with local circumstances to cause those persons who were affected most directly by the project to have the least practical influence in the political and administrative decisions that were eventually to lead to the loss of their property.Moreover, Nashville\u27s experience would seem to suggest that while the use of eminent domain on behalf of private institutions has been an integral part of American legal history, a vocal minority of citizens continues to resist the process on philosophic grounds that recall the attitude of Blackstone and the 18th century legal system towards private property. In large measure because they believed that eminent domain should not be exercised on behalf of a private university, a small number of persons whose land was to be taken by the Nashville project continued to resist the plan for seven years after its implementation had already begun. Their political and legal struggles were ultimately fruitless, but the time and energy required to reopen and resolve the issue of the project\u27s validity represented a considerable cost to the participants in the struggle as well as to the community as a whole. Nashville\u27s protracted struggle with its Section 112 urban renewal project would thus seem to indicate that a considerable social tension continues to exist be-tween a legal system which recognizes the use of eminent domain on behalf of private institutions and a system of personal values that continues to place a premium upon the inviolacy of private property. The tension between the two and the social struggle it perhaps inevitably creates must, in the end, be recognized as one of the inherent costs of using eminent domain to assist the activities of particular private institutions.This study does not attempt to trace all the benefits or effects flowing from a Section 112 urban renewal project and the use of eminent domain. The major focus is upon the concerns and social costs to the community, the residents and the private institutions involved. To this end, the authors have attempted to present, objectively, the practical results of the program\u27s implementation as well as the legal results determined by the judicial system

A psychometric appraisal of the DREEM

<p>Abstract</p> <p>Background</p> <p>The quality of the Educational environment is a key determinant of a student centred curriculum. Evaluation of the educational environment is an important component of programme appraisal. In order to conduct such evaluation use of a comprehensive, valid and reliable instrument is essential. One of most widely used contemporary tools for evaluation of the learning environment is the Dundee Ready Education Environment Measure (DREEM). Apart from the initial psychometric evaluation of the DREEM, few published studies report its psychometric properties in detail. The aim of this study was to examine the psychometric quality of the DREEM measure in the context of medical education in Ireland and to explore the construct validity of the device.</p> <p>Methods</p> <p>239 final year medical students were asked to complete the DREEM inventory. Anonymised responses were entered into a database. Data analysis was performed using PASW 18 and confirmatory factor analysis performed.</p> <p>Results</p> <p>Whilst the total DREEM score had an acceptable level of internal consistency (alpha 0.89), subscale analysis shows that two subscales had sub-optimal internal consistency. Multiple group confirmatory factor analysis (using Fleming's indices) shows an overall fit of 0.76, representing a weak but acceptable level of fit. 17 of the 50 items manifest fit indices less than 0.70. We sought the best fitting oblique solution to the 5-subscale structure, which showed large correlations, suggesting that the independence of the separate scales is open to question.</p> <p>Conclusions</p> <p>There has perhaps been an inadequate focus on establishing and maintaining the psychometric credentials of the DREEM. The present study highlights two concerns. Firstly, the internal consistency of the 5 scales is quite variable and, in our sample, appears rather low. Secondly, the construct validity is not well supported. We suggest that users of the DREEM will provide basic psychometric appraisal of the device in future published reports.</p