Main demographic and clinical characteristics of the RA study cohort.

<p>Main demographic and clinical characteristics of the RA study cohort.</p

Factors associated with radiographic progression by the Sharp-van der Heijde score (total and by subscales): results of the bivariate analysis.

<p>Factors associated with radiographic progression by the Sharp-van der Heijde score (total and by subscales): results of the bivariate analysis.</p

Factors associated with radiographic progression by the Sharp-van der Heijde score (total and by subscales): results of the multivariate regression models by backward stepwise selection.

<p>Factors associated with radiographic progression by the Sharp-van der Heijde score (total and by subscales): results of the multivariate regression models by backward stepwise selection.</p

Combined analysis of <i>CD247</i> polymorphisms according to disease and serological status.

<p>Controls are used as reference for all comparisons.</p>*<p>Allelic Mantel-Haenszel fixed effects model.</p><p>RA, rheumatoid arthritis; RF, rheumatoid factor; anti-CCP, anti-cyclic citrullinated peptide; +, positive; −, negative; P_BD, Breslow-Day P-Value.</p

IFN-γ levels (pg/ml) in patients without CV events (left) or with CV events (right) according to genotypes and allele distribution of rs3430561 polymorphism.

<p>IFN-γ levels (pg/ml) in patients without CV events (left) or with CV events (right) according to genotypes and allele distribution of rs3430561 polymorphism.</p

Comparison of IFN-γ levels in patients with or without CV events according to <i>IFNG</i> rs2430561 alleles in an adjusted ANCOVA model.

*<p>Analyses adjusted for gender, age at rheumatoid arthritis diagnosis, follow-up time from disease diagnosis, and classic cardiovascular risk factors: hypertension, diabetes mellitus, dyslipidemia, obesity and smoking habit.</p

Comparison of carotid artery intima media thickness (IMT) according to <i>IFNG</i> rs2430561 variant.

<p>Comparison of carotid artery intima media thickness (IMT) according to <i>IFNG</i> rs2430561 variant.</p

IFN-γ serum levels (pg/ml) in a subsample of patients (n = 153) with RA stratified according to the presence or absence of CV events.

*<p>Analyses adjusted for gender, age at RA diagnosis, follow-up time from the disease diagnosis, presence or absence of shared epitope, and classic cardiovascular risk factors.</p

Comparison of carotid artery intima-media thickness (cIMT) according to <i>CD154</i> rs3092920 and rs3092952 SNPs.

<p>Comparison of carotid artery intima-media thickness (cIMT) according to <i>CD154</i> rs3092920 and rs3092952 SNPs.</p

Differences in genotype and allele frequencies of <i>IFNG</i> rs2430561 functional gene variant between RA patients with CV events <i>versus</i> patients without CV events.

<p>CV: Cardiovascular. Except for OR, values are number (%). OR [95% CI]: Odds Ratio with 95% Confidence Interval.</p