5 research outputs found
Plasma lipid profiles discriminate bacterial from viral infection in febrile children
- Author
- Abdulla Amina F.
- Abelake Eugenia
- Adeel Abdul O.A.
- Aebi C.
- Agapow Paul Michael
- Agbeko R.
- Agyeman P.
- Anderson Suzanne T. B.
- Antonio Martin
- Baer W.
- Barham Heather
- Barral-Arca Ruth
- Barrios Xavier Gabaldó
- Bartlett Maeve
- Baumgart Hinrich
- Baumgartner Markus
- Behrends Uta
- Bellos Evangelos
- Berger C.
- Bernhard-Stirnemann S.
- Biebl Ariane
- Binder Alexander
- Birnbacher Robert
- Blanke Jan-Gerd
- Boeddha Navin P.
- Boelke Carsten
- Bojang Kalifa
- Bokhandi Sumit S.
- Breukels Meike A.
- Breuling Kai
- Brinkman Daniëlle M.C.
- Brió Sanagustín Sonia
- Brunner Jürgen
- Buller Maria
- Camuzeaux Stephane
- Carreras Eduardo
- Carrol Enitan
- Carter Stephanie
- Cebey-López Miriam
- Coin Lachlan
- Cole Fatoumata
- Concha-Torre Andres
- Contreras J. Ruiz
- Cooke Elizabeth Fernández
- Crate Lindsay
- Curras-Tuala MJ.
- Dahlem Peter
- Davies Patrick
- de Groot Ronald C.A.
- de Korte Carla C.M.M.
- de Vries Esther
- de Waal Wouter J.
- Deep Akash
- Dekkers Roel
- Dietrich Beate
- Dings-Lammertink Anouk
- Doedens Rienus A.
- Donker AlbertineE.
- Dousma Mieke
- Driessen Gertjan Jan A.
- Eber Ernst
- Eleftherohorinou Hariklia
- Elias Johannes
- Ellacuriagal Antonio Salas
- Emhofer Josef
- Emonts Marieke
- Etschmaier Rosa
- Faber Tina E.
- Farr Sebastian
- Faust Saul
- Fernandez Silveira Laura
- Fernández Reyes
- Fink Colin
- Forte Miguel Sanchez
- Fortune Peter-Marc
- Frederick H.
- Galassini Rachel
- García Natalia
- Gerrits Gerardus Peter Jm M.
- Gerver Jan A.M.
- Giannoni E.
- Giménez-Sánchez Francisco
- Girtler Ylenia
- Gomez-Rial Jose
- Gormley Stuart
- Grela Beiroa Andrea
- Gribbin Andrew
- Grigorow Irina
- Guillén Sara
- Gómez-Carballa Alberto
- Hamilton Shea
- Hardy Katie
- Hasters P.
- Hazelzet Jan
- Heidema Jojanneke
- Heimann Konrad
- Heininger U.
- Herberg Jethro A.
- Hoggart Clive
- Hourmat Bernardo
- Hudnott Phil
- Ibarrondo Cristina Epalza
- Iglesias Pilar Leboráns
- Ihm Ulrike
- Inwald David
- Jackson Heather R.
- Jacobs Monique A.M.
- Jansen Nicolaas Johannes Georgius
- Jaros Zdenek
- Jennings R.
- Johnston J.
- Justicia-Grande Antonio
- Kaforou Myrsini
- Kahlert C.
- Kalhoff Hermann
- Kaulfersch Wilhelm
- Kawczynski Pawel
- Kebbeh Ngange
- Kemen Christoph
- Kenwright R.
- khan Saidy
- Klobassa Daniela S.
- Klocker Nina
- Klucovska Kristine
- Kneyber Martin Christiaan Jacques
- Kohlmaier B.
- Komini Eleni
- Koopman-Keemink Yvonne
- Kramer Lydia
- Kuijpers T. W.
- Köster Bernhard
- Langenhorst Veerle J.
- Leusink José
- Levin Michael
- Lewis Matthew R.
- León-León María Cruz
- Loza Bettina F.
- Lozano María José
- Maconochie Ian
- Martinez-Santos Alba-Elena
- Martinon-Torres Federico
- MartinónTorres Nazareth
- Mashbat Meg
- McClure Myra
- McCorkell Jenni
- McCready Sharon
- Menikou Stephanie
- Merth Istvan T.
- Miedema Carien J.
- Mingorance Álvaro Navarro
- Momodou None
- Moreno David
- Morillo Gutiérrez Beatriz
- Mustafa Sobia
- Nadel Simon
- Navarra Helen
- Navarro Marisa
- Neeleman Chris
- Neth Olaf
- Neubert Antje
- Niederer-Loher A.
- Nijman Ruud Gerard
- Noordzij Jeroen G.
- Nsirim Eniola
- O'Neill Lauren
- Obihara Charlie C.C.
- Ortner Daniel
- Oñate Vergara Eider
- Pacheco Pablo Obando
- Padilla Ma del Carmen Martínez
- Pajkrt Dasja
- Palacios Alba
- Pardo-Seco Jacobo
- Patel Rekha
- Patel Sanjay Valabh
- Pathan Nazima
- Paulus Stéphane
- Pescollderungg Lydia
- Peters Mark
- Pfurtscheller Klaus
- Philipsen H.L.A.
- Pinnock Elli
- Pischedda Sara
- Pollard AJ.
- Poortman Geriska H.
- Posfay-Barbe K.M.
- Potgieter Steph T.
- Potjewijd Joke
- Power Sue
- Pérez Belén Mosquera
- Rahman Rahmeen
- Ramaiah Raghu
- Redondo Collazo Lorenzo
- Reiter Karl
- Relly C.
- Reyes Susana Beatriz
- Ridout Jenna
- Ristic Goran
- Rivero Calle Irene
- Rodríguez-Tenreiro Carmen
- Rojo Pablo
- Rosias Philippe P.R.
- Royad C.
- Rödl Siegfried
- Sagmeister Manfred
- Salas Antonio
- Sancho Shimizu Vanessa
- Sanders Elisabeth A. M.
- Sands Caroline
- Sarr Isatou
- Schlapbach Luregn
- Schweintzger Nina
- Secka Fatou
- Sellner Andrea
- Serén Fernández Sonia
- Sey Gibbi
- Silva María Del Sol Porto
- Sonnleitner Astrid
- Sperl Matthias
- Sprong Tom
- Standing Fran
- Stelzl Wolfgang
- Stocker M.
- Sánchez José María
- Tato Luis Manuel Prieto
- ten Tussher Gavin W.
- Thakker Clare
- Thio Bernard J.
- Thomas Gilleh
- Thurston Sarah
- Till Holger Karl H.
- Tramper-Stranders Gerdien A.
- Trobisch Andreas
- Tuffrey Catherine
- Universitat Autònoma de Barcelona
- van de Beek Diederik
- van der Ende Arie
- Van der Flier Michiel
- van der Meer H.
- van Deuren M.
- van Furth Marceline
- van Kuppevelt A.J.M.
- van Overbeek - van Gils A. Lidy T.
- van Wermeskerken A.M.
- Veen J. Homan-van der
- Vega Ana Karina
- Verwijs W.A.
- Vicente Luisa García
- Vierzig Anne
- Vilanova-Trillo Lucía
- Vivanco Ana
- Vogel Ulrich
- Wang Xinzhu
- Weingarten Christina
- Welke Stefanie
- White Deborah K.
- White Sonia
- Willis Louise
- Wimmer Andreas
- Wintergerst Uwe
- Wolfs T.F.W.
- Wright Victoria
- Wüller Daniel
- Young Zoe
- Zaunschirm Andrew
- Zenz Werner
- Ziuraite Ieva
- Álvarez Cristina Álvarez
- Álvez González Fernando
- Žukovskaja Veslava
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics
Plasma lipid profiles discriminate bacterial from viral infection in febrile children
- Author
- Abdulla A. (Amina)
- Abelake E. (Eugenia)
- Adeel A.O.A. (A. O.A.)
- Aebi C. (Christoph)
- Aebi C. (Christoph)
- Agapow P. (Paul)
- Agbeko R. (Rachel)
- Agyeman P. (Philipp)
- Anderson S. (Suzanne)
- Antonio M. (Martin)
- Baer W. (Walter)
- Barham H. (Heather)
- Barral-Arca R. (Ruth)
- Barrios X.G. (Xavier Gabaldó)
- Bartlett M. (Maeve)
- Baumgart H. (Hinrich)
- Baumgartner M. (Markus)
- Behrends U. (Uta)
- Beiroa A.G. (Andrea Grela)
- Bellos E. (Evangelos)
- Berger C. (Christoph)
- Berger C. (Christoph)
- Bernhard-Stirnemann S. (Sara)
- Biebl A. (Ariane)
- Binder A. (Alexander)
- Birnbacher R. (Robert)
- Blanke J.-G. (Jan-Gerd)
- Boeddha N.P. (Navin)
- Boelke C. (Carsten)
- Bojang K. (Kalifa)
- Bokhandi S. (S.)
- Breukels M.A. (M. A.)
- Breuling K. (Kai)
- Brinkman D.M.C.
- Brunner J. (Jürgen)
- Buller M. (Maria)
- Camuzeaux S. (Stephane)
- Carreras E. (Eduardo)
- Carrol E.D. (Enitan)
- Carter S. (Stephanie)
- Cebey-López M. (Miriam)
- Coin L.M.J. (Lachlan M. J.)
- Cole F. (Fatoumata)
- Contreras J.R. (J. Ruiz)
- Cooke E.F. (Elizabeth Fernández)
- Crate L. (Lindsey)
- Curras-Tuala M.J. (María José)
- Dahlem P. (Peter)
- Davies P. (P.)
- de Korte C.C.M.M. (C. C.M.M.)
- de Vries E. (E.)
- Deep A. (Akash)
- Dekkers R. (R.)
- Deuren M. (Marcel) van
- Dietrich B. (Beate)
- Dings-Lammertink A. (A.)
- Doedens R.A. (R. A.)
- Donker A.E. (A.)
- Dousma M. (M.)
- Driessen G.J.A. (Gertjan)
- Eber E. (Ernst)
- Eleftherohorinou H. (Hariklia)
- Elias J. (Johannes)
- Ellacuriagal A.S. (Antonio Salas)
- Emhofer J. (Josef)
- Emonts M. (Marieke)
- Emonts M. (Marieke)
- Ende A. (A.) van der
- Etschmaier R. (Rosa)
- Faber T.E. (T. E.)
- Farr S. (Sebastian)
- Faust D. (Dominik)
- Fernández R. (Reyes)
- Fernández S.S. (Sonia Serén)
- Fink C. (Colin)
- Flier M. (Michiel) van der
- Forte M.S. (Miguel Sánchez)
- Fortune P.M. (P. M.)
- Frederick H. (Hannah)
- Galassini R. (Rachel)
- García N. (Natalia)
- Gerrit G.P.J.M. (Gerardus)
- Gerver J.A.M. (J. A.M.)
- Giannoni P.
- Girtler Y. (Ylenia)
- González F.Á. (Fernando Álvez)
- Gormley S. (Stuart)
- Grande A.J. (Antonio Justicia)
- Gribbin A. (Andrew)
- Grigorow I. (Irina)
- Groot R. (Ronald) de
- Guillén S. (Sara)
- Gutiérrez B.M. (Beatriz Morillo)
- Gómez-Carballa A. (Alberto)
- Hamilton S. (Shea)
- Hardy K. (Katie)
- Hasters P. (Paul)
- Hazelzet J.A. (Jan)
- Heidema J. (Jojanneke)
- Heimann K. (Konrad)
- Heininger U. (Ulrich)
- Herberg J.A. (Jethro A.)
- Hoggart C. (Clive)
- Hourmat B. (Bernardo)
- Hudnott P. (Phil)
- Ibarrondo C.E. (Cristina Epalza)
- Iglesias P.L. (Pilar Leboráns)
- Ihm U. (Ulrike)
- Inwald D. (David)
- Jackson H. (Heather)
- Jacobs M.A.M. (M. A.M.)
- Jansen N.J.G. (N. J.G.)
- Jaros Z. (Zdenek)
- Jennings R. (Rebecca)
- Johnston J. (Joanne)
- Kaforou M. (Myrsini)
- Kahlert C. (Christian)
- Kalhoff H. (Hermann)
- Kaulfersch W. (Wilhelm)
- Kawczynski P. (P.)
- Kebbeh N. (Ngange)
- Kemen C. (Christoph)
- Kenwright R. (Rhian)
- khan S. (Saidy)
- Klobassa D.S. (Daniela S.)
- Klocker N. (Nina)
- Klucovska K. (K.)
- Kneyber M.C.J. (M. C.J.)
- Kohlmaier B. (Benno)
- Komini E. (Eleni)
- Koopman-Keemink Y. (Yvonne)
- Kramer L. (Lydia)
- Kuijpers T.T. (Taco T.)
- Köster B. (Bernhard)
- Langenhorst V.J. (V. J.)
- Leusink J. (J.)
- Levin M. (Michael)
- Lewis M.R. (Matthew R.)
- León M.C.L. (María Cruz León)
- Loza B.F. (Bettina F.)
- Lozano M.J. (María José)
- MacOnochie I.K. (Ian)
- Martinon-Torres F. (Federico)
- Martinón-Torres F. (Federico)
- MartinónTorres N. (Nazareth)
- Mashbat M. (Meg)
- McClure M. (Myra)
- McCorkell J. (Jenni)
- McCready S. (Sharon)
- Menikou S. (Stefanie)
- Merth I.T. (I. T.)
- Miedema C.J. (C. J.)
- Mingorance Á.N. (Álvaro Navarro)
- Momodou ()
- Moreno D. (David)
- Mustafa S. (Sobia)
- Nadel S. (Simon)
- Navarra H. (Helen)
- Navarro M. (Marisa)
- Neeleman C. (C.)
- Neth O. (Olaf)
- Neubert A. (Antje)
- Niederer-Loher A. (Anita)
- Nijman R.G. (Ruud)
- Noordzij J.G. (Jeroen)
- Nsirim E. (Eniola)
- Obihara C.C. (Charlie C.)
- Ortner D. (Daniel)
- O’Neill L. (Lauren)
- Pacheco P.O. (Pablo Obando)
- Padilla M.C.M. (Ma del Carmen Martínez)
- Pajkrt D. (D.)
- Palacios A. (Alba)
- Pardo-Seco J. (Jacobo)
- Patel R. (Rekha)
- Patel S.Y. (Smita Y.)
- Pathan D.N. (Dr N)
- Paulus S.C. (Stephane C.)
- Pescollderungg L. (Lydia)
- Peters M. (Mark)
- Pfurtscheller K. (Klaus)
- Philipsen H.L.A. (H. L.A.)
- Pinnock E. (Elli)
- Pischedda S. (Sara)
- Pollard A.J. (Andrew J.)
- Poortman G.H. (G. H.)
- Posfay-Barbe K.M. (Klara M.)
- Potgieter S.T. (S. T.)
- Potjewijd J. (J.)
- Power S. (Sue)
- Pérez B.M. (Belén Mosquera)
- Rahman R. (Rahmeen)
- Ramaiah R. (R.)
- Redondo-Collazo L. (Lorenzo)
- Reiter K. (Karl)
- Relly C. (Christa)
- Reyes S.B. (Susana Beatriz)
- Rial J.G. (Jose Gómez)
- Ridout J. (Jenna)
- Ristic G. (Goran)
- RiveroCalle I. (Irene)
- Rodríguez-Tenreiro C. (Carmen)
- Rojo P. (Pablo)
- Rosias P.P.R. (Philippe)
- Royad C. (C.)
- Rödl S. (Siegfried)
- Sagmeister M. (Manfred)
- Salas A. (Antonio)
- Sanagustín S.B. (Sonia Brió)
- Sancho-Shimizu V. (Vanessa)
- Sanders E.A.M. (E. A.M.)
- Sands C. (Caroline)
- Santos A.E.M. (Alba Elena Martínez)
- Sarr I. (Isatou)
- Schlapbach L.J. (Luregn)
- Schweintzger N.A. (Nina A.)
- Secka F. (Fatou)
- Sellner A. (Andrea)
- Sey G. (Gibbi)
- Silva M.S.P. (María del Sol Porto)
- Silveira L.F. (Laura Fernández)
- Sonnleitner A. (Astrid)
- Sperl M. (Matthias)
- Sprong T. (Tom)
- Standing F. (Fran)
- Stelzl W. (Wolfgang)
- Stocker M. (Martin)
- Sánchez F.G. (Francisco Giménez)
- Sánchez J.M.M. (José María Martinón)
- Tato L.M.P. (Luis Manuel Prieto)
- ten Tussher G.W. (G. W.)
- Thakker C. (Clare)
- Thio B.J. (B. J.)
- Thomas G. (Gilleh)
- Thurston S. (Sarah)
- Till H. (Holger)
- Torre A.C. (Andrés Concha)
- Tramper-Stranders G.A. (Gerdien)
- Trillo L.V. (Lucía Vilanova)
- Trobisch A. (Andreas)
- Tuffrey C. (Catherine)
- van de Beek D. (D.)
- van der Meer H. (H.)
- van Furth A.M.T. (A. M. Tutu)
- van Kuppevelt A.J.M. (A. J.M.)
- van Overbeek – van Gils A.L.T. (A. L.T.)
- van Wermeskerken A.M. (A. M.)
- Veen J.H.-V. (J. Homan-van der)
- Vega A. (Ana)
- Vergara E.O. (Eider Oñate)
- Verwijs W.A. (W. A.)
- Vicente L.G. (Luisa García)
- Vierzig A. (Anne)
- Vivanco A. (Ana)
- Vogel U. (Ulrich)
- Waal W.J. (Wouter) de
- Wang X. (Xinzhu)
- Weingarten C. (Christina)
- Welke S. (Stefanie)
- White D. (Deborah)
- White S. (Sonia)
- Willis L. (Louise)
- Wimmer A. (Andreas)
- Wintergerst U. (Uwe)
- Wolfs T.F.W. (T. F.W.)
- Wright V.J. (Victoria)
- Wüller D. (Daniel)
- Young Z. (Zoe)
- Zaunschirm A. (Andrew)
- Zenz W. (Werner)
- Ziuraite I. (Ieva)
- Álvarez C.Á. (Cristina Álvarez)
- Žukovskaja V. (Veslava)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2019
- Field of study
Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection ar
Genomic investigations of unexplained acute hepatitis in children
- Author
- Abdulla Amina
- Aebi Christoph
- Agbeko Rachel
- Aggelos Pefanis
- Agranoff Dan
- Agwuh Ken
- Agyeman Philipp
- Alba-Alejandre Irene
- Ali Ladan
- Alkema Wynand
- Allen Karen
- Alrabiah Dimah K.
- Amatya Puja
- Anderson Glenn
- Anderson Suzanne
- Andrade Catarina
- Andreani Julien
- Anpananthar Amutha
- Ansari Imran
- Antinao Diaz Juan F.
- Arif Tasnim
- Armstrong Diane
- Armstrong Jane A.
- Armstrong Lawrence
- Asgarian Zeinab
- Atkinson Laura
- Avcin Tadej
- Avramoska Tanja
- Baas Bryan
- Bahovec Natalija
- Baillie Kenneth
- Balode Anda
- Bamford Alasdair
- Barendregt A. M.
- Barral-Arca Ruth
- Barzdina Arta
- Barzdina Elza
- Basmaci Romain
- Bath David
- Bauchinger Sebastian
- Baumard Lucas
- Baumgart Hinrich
- Baxter Frances
- Bayzid Nadua
- Beer Sally
- Bell Ashley
- Bell Claire
- Bell Kathryn
- Bellini Arianna
- Bello Xabier
- Bellos Evangelos
- Benesch Martin
- Benesch Martin
- Bennet Joshua
- Berger Christoph
- Bernhard-Stirnemann Sara
- Beudeker Coco R.
- Beveridge Laura
- Bibi Sagida
- Bidlingmaier Christoph
- Biesbroek Giske
- Bijukchhe Sanjeev Man
- Billing Kyle
- Binder Alexander
- Binder Vera
- Birt Mark
- Bogovic Petra
- Bohmova Kristyna
- Bojang Kalifa
- Bont Louis J.
- Borensztajn Dorine M.
- Bories Pauline
- Branch Nicole
- Brengel-Pesce Karen
- Breuer Judith
- Broderick Claire
- Brotherton Helen
- Brown Julianne R.
- Brown Rachel
- Buddle Sarah
- Burling Sara
- Buschbeck Judith
- Cabello Laura
- Calle Irene Rivero
- Calvo-Bado Leo
- Campos Luis
- Candlish Janie
- Capozzi Lisa
- Carnota Sandra
- Caro Ivan
- Carrol Enitan D.
- Carson Gail
- Carter Michael
- Carter Michael J.
- Castellano Sergi
- Castro Maria Barreiro
- Cebey-López Miriam
- Ceesay Samba
- Celma Cristina
- Ceolotto Astrid
- Chan Adora
- Chand Meera
- Channon-Wells Samuel
- Charalambos Gogos
- Chikowore Primrose
- Chiurchiù Sara
- Chukkambotla Srikanth
- Chériaux Laura
- Clark Richard
- Clohisey Sara
- Cocklin Elizabeth
- Cohen Jonathan
- Cohen Laure
- Collings Kalvin
- Collins Emma
- Connon Maggie
- Cooray Samantha
- Cotillon Marie
- Counsell John R.
- Coutts Audrey
- Cresswell Fiona
- Crulley Stephen
- Cunnington Aubrey
- Curras-Tuala María José
- Czap Agata
- D'alessandro Umberto
- D?Souza Giselle
- Dall Anna
- Danekova Nevena
- Danhauser Katharina
- Darboe Saffiatou
- Darnell Sarah
- Daubney Esther
- Davis Francesca
- Davoust Juraté
- Dawson Joy
- de Groc Thibault
- de Groot Ronald
- de Haan L.
- de Jonge Marien I.
- de Silva Thushan
- de Tugny Alice
- de Vries Gabriella
- De Surjo
- De Tisham
- Deep Akash
- Deheragoda Maesha
- Deksne D?rta
- Devine Kirsty
- Dewez Juan Emmanuel
- Dewez Manuel
- Diaba Cynthia
- Dickinson Holly
- Dik W.
- Donelly Lorna
- Donohue Chloe
- Dorward David
- Drysdale Simon B.
- Dudley Julia
- Dunning Jake
- DuRand Ingrid
- Eber Ernst
- Eisen Sarah
- Eleftheriou Irini
- Ellis Donna
- Elorrieta Leire Estramiana
- Emonts Marieke
- Ensom Ruth
- Epalza Cristina
- Estrada-Rivadeneyra Diego
- Evans Benjamin
- Fabian Daniel
- Farmer Sarah
- Farto Cristina Balo
- Faust Saul
- Fawkes Angie
- Ferguson Susie
- Fernández Sonia Serén
- Feuchtinger Tobias
- Fidler Katy
- Fink Colin
- Finlayson Lauren
- Fish Matthew
- Fitchett Elizabeth
- Fletcher Tom
- Floyd Sharon
- Fullerton Duncan
- Galassini Rachel
- Gallagher Eileen
- Gallistl Siegfried
- Gannon Louise
- García Mirian Ben
- Gardiner Emma
- Garg Sanjeev
- Geissler J.
- Georgiou Pantelis
- Gerrits G. P. J. M.
- Giannoni Eric
- Gijón Manuel
- Gilchrist Tammy
- Gissen Paul
- Giuseppe Martina Di
- Gloerich Jolein
- Goetschalckx Ines
- Gonzalez Suam
- González Fernando Álvez
- Gores Gunther
- Gormley Stuart
- Graham Clive
- Grammatikopoulos Tassos
- Gravele Dagne
- Griese Matthias
- Grope Ilze
- Gruppen Mariken
- Guerra-Assunção José Afonso
- Gunson Rory
- Gurung Meeru
- Gutiérrez Lourdes
- Gómez-Carballa Alberto
- Haas Nikolaus
- Habgood-Coote Dominic
- Hadzic Nedim
- Hafezi Katarzyna
- Hagedoorn Nienke N.
- Haidl Harald
- Hamilton Shea
- Hamzah Lisa
- Hanlon Killian S.
- Hanson Anita
- Hardwick Hayley
- Harper Rosemary
- Hartshorn Stuart
- Hatcher James
- Hauer Almuthe
- Heidema J.
- Heightman Melissa
- Heininger Ulrich
- Henderson Paul
- Henriet Stefanie
- Herberg Jethro
- Hernández Irene
- Hibberd Martin
- Hickey Naomy
- Ho Antonia Y. W.
- Hodgson Luke
- Hoffmann Florian
- Hoggart Clive
- Holden Jennifer
- Holden Matt
- Hope Susan
- Hopton Sarah
- Hoschler Katja
- Houlihan Catherine
- Hourmat Sara
- Howman Ruth
- Hude Christa
- Huijnen Martijn
- Hutchinson J. Ciaran
- Hösele Susanne
- Iglesias Marisol Vilas
- Iglesias Pilar Leboráns
- Ijaz Samreen
- Ioanna Stergiou
- Irving Clare
- Isaacs John
- Jackson Heather
- Jacques Thomas S.
- Jansen Machiel H.
- Jarman Heather
- Jennings Aislinn
- Jennings Paul
- Jennings Rebecca
- Johnston Joanne
- Jones Amaryl
- Jongerius Ilse
- Jorgensen Rikke
- Juranek Sabrina
- Kaforou Mysini
- Kahlert Christian
- Kandasamy Rama
- Kapper Andreas
- Kappler Matthias
- Karolina Akinosoglou
- Kaufer Benedikt B.
- Kavanagh James
- Keil Julia
- Keldorfer Markus
- Kelgeri Chayarani
- Kelly Dominic F.
- Kelly Sarah
- Kenny Julia
- Khalid Nosheen
- Khanijau Aakash
- Khoo Say
- Kim Eunjung
- King Sharon
- Kishore Shyla
- Kitanovski Lidija
- Kloosterhuis Lieke
- Kohlfürst Daniela S.
- Kohlmaier Benno
- Kolberg Laura
- Kolnik Mojca
- Koshy George
- Krenn Larissa
- Kuijpers Taco
- Kuijpers Taco
- Lachaume Noémie
- Laivacuma Sniedze
- Laivacuma Sniedze
- Law Andrew
- Le Sébastien
- Lee Jack C. D.
- Leigh Simon
- Leiner Tamas
- Leitch Karen
- Leitner Manuel
- Lenihan Rebecca
- Lennon Alexander
- Lett Lauren
- Leurent Baptiste
- Levin Michael
- Lewis-Burke Nadia
- Liebeschuetz Susan
- Lim Emma
- Limb James
- Lin Naomi
- Linforth Michelle
- Little Jeff
- Liu Ching-Chuan
- Logan Sheena
- Lubinda Tim
- Luca Maia De
- Lurz Eberhard
- Löffler Sabine
- MacFarlane Susan
- MacGillivray Louise
- Machín Fátima
- Mackerness Christine
- Maclean Alan
- Maconochie Ian
- Macpherson Hannah
- Madelane Monta
- Maier Esther
- Malcolm Ivone Lancoma
- Mallet François
- Mandal Sema
- Manzanares Ángela
- Manzano Jesus-Rodriguez
- Maritsi Despoina
- Marjaneh Mahdi Moradi
- Markos Maragos
- Marmarinos Antonios
- Marmarinos Antonis
- Martin Bernal Luz Marina
- Martin Alex
- Martin Darran
- Martin Joanne
- Martin Mike
- Martinón-Torres Federico
- Martinón-Torres Nazareth
- Matovu Elijah
- Matthews Peter
- McAlinden Paul
- McArdle Andrew
- McCafferty Sarah
- McDonald Sam
- McDonald Sarah E.
- McDonnell Anne
- McGenily Laura
- McGill Fiona
- McKay Sarah
- Meiere Anija
- Meierford Anne
- Menikou Stephanie
- Merson Laura
- Michalis Voulgarelis
- Miedema C. J.
- Millar Margaret
- Miller Caroline
- Miller Danielle
- Milligan Barry
- Mills Sarah
- Miners Alec
- Mistry Ravi
- Mita Andrew
- Moll Henriëtte A.
- Mommert Marine
- Mommert-Tripon Marine
- Mondo Diana
- Montgomery Kylie-Ann
- Moore Catherine
- Moots Robert
- Moradi Marjaneh Mahdi
- Morfopoulou Sofia
- Morrice John
- Morrice Kirstie
- Morris Craig
- Moser Nicolas
- Muench Georg
- Murdoch David R.
- Murphy Lee
- Mustafa Sobia
- Márquez Sonia
- Nagelkerke Sietse
- Nahtigal Mirijam
- Nasher Magda
- Natalucci Giancarlo
- Neeleman C.
- Neill Claire
- Neshat Samira
- Newal Karen
- Newall Karen
- Ng Joanne
- Nichols Samuel
- Niederer-Loher Anita
- Niedrist Tobias
- Nijman Ruud
- Nijman Ruud
- Nokalna Ieva
- Nordberg Gudrun
- Norris Lucy
- Noursadeghi Mahdad
- Nyirenda Maggie
- O'Connor Daniel
- O?Reilly Peter
- O?Riordan Sean
- Obihara C. C.
- Obosi Lauren
- Odam Miranda
- Oliver Zoe
- Ong Kim-Thanh
- Oosthoek Wilma
- Oosthuyzen Wilna
- Openshaw Peter J. M.
- Ora Miguel Sadiki
- Osterman Veronika
- Owen Dan
- Pachot Alexandre
- Pajkrt D.
- Pajkrt Dasja
- Palmarini Massimo
- Panagiota Lourida
- Papst Lea
- Pardo-Seco Jacobo
- Patel Harsita
- Pathan Nazima
- Paulus Stéphane
- Paulus Stéphane
- Paulus Stéphane C.
- Pavare Jana
- Paz Ivonne Pena
- Pennisi Ivana
- Persand Salina
- Peters Mark
- Pfleger Andreas
- Pfurtscheller Klaus
- Philipsen Ria
- Pickering Ailsa
- Pierce Benjamin
- Pilch Heidemarie
- Pischedda Sara
- Player Jasmine
- Pokhrel Bhishma
- Pokorn Marko
- Pokorn Marko
- Pollara Gabriele
- Pollard Andrew J.
- Pollock Louisa
- Posfay-Barbe Klara M.
- Powell Natassia
- Powell Oliver
- Price Ashley
- Price David
- Price Nicholas
- Prunk Petra
- Pucuka Zanda
- Pérez Belén Mosquera
- Pölz Lena
- Rajic Glorija
- Rampling Tommy
- Ramsay Maxine
- Rashid Aqeela
- Redondo-Collazo Lorenzo
- Reich Jana
- Reid Ruth
- Reiter Karl
- Relly Christa
- Reschreiter Henrik
- Reynolds Tim
- Rhodes Mathew
- Rial Jose Gómez
- Richmond Vivien
- Riddell Anna
- Riedel Thomas
- Robbins Ceri
- Rodríguez Lidia Piñeiro
- Rodríguez-Tenreiro Carmen
- Roff Amy
- Rojo Pablo
- Romaine Sam
- Romani Lorenza
- Roome Tara
- Rosenheim Joshua
- Rowlands Emily
- Roy Sunando
- Rubick Lucy
- Rudzate Aleksandra
- Rughnani Prita
- Russell Clark D.
- Rusu Alexandra
- Rödl Siegfried
- Sagmeister Manfred G.
- Saidykhan Momodou
- Salas Antonio
- Santilli Giorgia
- Sarr Anna RocaIsatou
- Schlapbach Luregn
- Schlapbach Luregn J.
- Schlüchter Stefanie
- Schmied Patricia
- Schoen Carola
- Scholefield Barnaby J.
- Schonenberg D.
- Schonenberg Dieneke
- Schranz Rachel
- Schroepf Sebastian
- Schweintzger Nina A.
- Schöbi Nina
- Seal Matthew
- Secka Fatou
- Segal Terry
- Selecka Katrina
- Semple Malcolm Gracie
- Shackley Fiona
- Shah Priyen
- Shaji Mariya
- Shankar-Hari
- Shaw Victoria
- Shen Ching-Fen
- Shenton Geoff
- Shepherd Samantha J.
- Shrestha Shrijana
- Siam Ala?a
- Sidorova Aleksandra
- Simagan Teresa
- Simmonds Peter
- Simmons Ruth
- Skrabl-Baumgartner Andrea
- Solomon Tom
- Spencer Collette
- Sperl Matthias
- Sprenkeler Evelien
- Spyridis Nikos
- Srovin Tina Plankar
- Srpcic Anja
- Stampfer Laura
- Steele Michael
- Stevens Jake
- Stevens Molly
- Stocker Martin
- Stoiser Bianca
- Stoldere Diana
- Storey Nathaniel
- Strempfl Martina
- Strenger Volker
- Strijbosch Annelieke M.
- Strle Franc
- Suárez Carlos Durán
- Svile Dace
- Swingler Rachel
- Syggelou Kelly
- Sánchez José María Martinón
- Sée Hélène
- Tait Sarah
- Talts Tiina
- Tambouratzi Maria
- Tan Chantal
- Tappouni Luke J.
- Tauchert Maike K.
- Tavliavini Emma
- Tayler Rachel
- Tedder Richard S.
- Tempel Dennie
- Templeton Kate
- Thalassinos Konstantinos
- Thomas Daisy
- Thomson Emma
- Thomson Evelyn
- Thorson Stephen
- Tibby Shane
- Till Holger
- Tissing Wim J. E.
- Tkhayat Raja Ben
- Torres Montaguth Oscar Enrique
- Tramper-Stranders G. A.
- Trasorras Cristina Serén
- Treloar Owen
- Trobisch Andreas
- Tsolia Maria
- Turtle Lance C. W.
- Tutill Helena
- Urbane Urzula Nora
- Ushiro-Lumb Ines
- Usman Mariama
- Usuf Effua
- Valentine Lucille
- van Aerde Koen
- van de Kuip Martijn
- van den Berg J. M.
- van den Berg Merlijn
- van den Broek Bryan
- van der Flier Michiel
- van der Flier Michiel
- van der Giessen Ilona
- van der Kuip M.
- van der Velden Fabian
- van der Velden Fabian J. S.
- van der Zee Carlijn
- van Furth A. M.
- van Furth Marceline
- van Gool Alain J.
- van Hensbroek Michael Boele
- van Keulen Danielle
- van Leur M.
- van Mierlo G.
- Vastert Sebastiaan J.
- Venturini Cristina
- Vergnault Nathalie
- Verkuil Floris
- Vermont Clementien L.
- Vicente Luisa García
- Vijlbrief Daniel C.
- Villaverde Serena
- Vincek Katarina
- Vito Ortensia
- Voice Marie
- von Both Ulrich
- Vázquez Sara Rey
- Waddington Simon N.
- Wallia Diane
- Wallner Elmar
- Wang Shih-Min
- Ward Bryony
- Ward Catriona
- Watson Conall
- Weber Kathrin
- Wedderburn Catherine
- Wellings Lucy
- Wellman Paul
- Wham Murray
- White Deborah
- White Marie
- Whittaker Elizabeth
- Whittaker Paul
- Whittaker Thomas E.
- Willems Esther
- Williams Charlotte A.
- Williams Rachel
- Wilson Barbara
- Wilson Clare
- Winmill Helen
- Wolfs Tom F. W.
- Womersley Rebecca
- Wood Amanda
- Woodsford Phil
- Wright Victoria
- Wrobel Nicola
- Wyss Verena
- Wösten-van Asperen Roelie M.
- Xagorari Marietta
- Yeung Shunmay
- Zachariasse Joany
- Zaman Syed M. A.
- Zambon Maria
- Zandstra Judith
- Zavadska Dace
- Zennezini Chiozzi Riccardo
- Zenz Werner
- Zimmermann Elisa
- Zurl Christoph
- Zwerenz Manuela
- Publication venue
- Nature Research
- Publication date
- 30/03/2023
- Field of study
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children
Development of novel aminothiazole-comprising 5-LO inhibitors
- Author
- Publication venue
- 'Future Science Ltd'
- Publication date
- Field of study
Structure–activity relationship and in vitro
- Author
- Publication venue
- 'Future Science Ltd'
- Publication date
- Field of study