Mary Pauper: A Historical Exploration of Early Care and Education Compensation, Policy, and Solutions

The Early Educator Investment Collaborative is committed in our work to recognizing and understanding the historical context in which structural racism continues to present in the early childhood workforce and eliminating the systemic oppression that keeps many early childhood educators living in poverty. In 2021, Child Trends was selected to conduct a literature review and develop a policy and practice report to map the history of systemic racism in the U.S. and how it has influenced early childhood education (ECE) policy and practice, with a particular focus on educator pay and benefits, preparation, and workforce stability.This report articulates a landscape analysis and a set of recommendations for policy, practice, and future research to improve the professional status of early childhood educators. The intent of this work is to build a common understanding of the biggest equity issues impacting early childhood educators—historically and in the present day

Sit-to-Stand Symmetry in Individuals with Hip Pathology

Hip fractures occur approximately in 300K individuals aged 65+ annually post-fall 53.3% will sustain another fall; Mortality rate \u3e 25% The sit-to-stand (STS) task is impacted by hip fractures. vGRF asymmetry with STS post-hip fracture (Houck et al.) Hip fracture side \u3c non-fractured side Asymmetry not fully explained by LE strength in hip fracture nor CV

Fractional Noether's theorem in the Riesz-Caputo sense

We prove a Noether's theorem for fractional variational problems with Riesz-Caputo derivatives. Both Lagrangian and Hamiltonian formulations are obtained. Illustrative examples in the fractional context of the calculus of variations and optimal control are given.Comment: Accepted (25/Jan/2010) for publication in Applied Mathematics and Computatio

Psychological stress and arterial stiffness in Korean Americans

Arterial stiffness is identified as a causative factor for hypertension. The purpose of this study was to explore the relationship between psychological stress and arterial stiffness in Korean Americans

Curcumin Ingestion Inhibits Mastocytosis and Suppresses Intestinal Anaphylaxis in a Murine Model of Food Allergy

IgE antibodies and mast cells play critical roles in the establishment of allergic responses to food antigens. Curcumin, the active ingredient of the curry spice turmeric, has anti-inflammatory properties, and thus may have the capacity to regulate Th2 cells and mucosal mast cell function during allergic responses. We assessed whether curcumin ingestion during oral allergen exposure can modulate the development of food allergy using a murine model of ovalbumin (OVA)-induced intestinal anaphylaxis. Herein, we demonstrate that frequent ingestion of curcumin during oral OVA exposure inhibits the development of mastocytosis and intestinal anaphylaxis in OVA-challenged allergic mice. Intragastric (i.g.) exposure to OVA in sensitized BALB/c mice induced a robust IgE-mediated response accompanied by enhanced OVA-IgE levels, intestinal mastocytosis, elevated serum mMCP-1, and acute diarrhea. In contrast, mice exposed to oral curcumin throughout the experimental regimen appeared to be normal and did not exhibit intense allergic diarrhea or a significant enhancement of OVA-IgE and intestinal mast cell expansion and activation. Furthermore, allergic diarrhea, mast cell activation and expansion, and Th2 responses were also suppressed in mice exposed to curcumin during the OVA-challenge phase alone, despite the presence of elevated levels of OVA-IgE, suggesting that curcumin may have a direct suppressive effect on intestinal mast cell activation and reverse food allergy symptoms in allergen-sensitized individuals. This was confirmed by observations that curcumin attenuated the expansion of both adoptively transferred bone marrow-derived mast cells (BMMCs), and inhibited their survival and activation during cell culture. Finally, the suppression of intestinal anaphylaxis by curcumin was directly linked with the inhibition of NF-kappaB activation in curcumin-treated allergic mice, and curcumin inhibited the phosphorylation of the p65 subunit of NF-kappaB in BMMCs. In summary, our data demonstrates a protective role for curcumin during allergic responses to food antigens, suggesting that frequent ingestion of this spice may modulate the outcome of disease in susceptible individuals

Executive Summary - Natural Gas and the Transformation of the U.S. Energy Sector: Electricity

In November 2012, the Joint Institute for Strategic Energy Analysis (JISEA) released a new report, 'Natural Gas and the Transformation of the U.S. Energy Sector: Electricity.' The study provides a new methodological approach to estimate natural gas related greenhouse gas (GHG) emissions, tracks trends in regulatory and voluntary industry practices, and explores various electricity futures. The Executive Summary provides key findings, insights, data, and figures from this major study

Patients with allergic rhinitis and allergic asthma share the same pattern of eosinophil and neutrophil degranulation after allergen challenge

<p>Abstract</p> <p>Background</p> <p>Patients with allergic rhinitis and allergic asthma demonstrate comparable local and systemic eosinophil inflammation, and yet they present with different clinical pictures. Less is even known about the contribution of neutrophil inflammation in allergic diseases. The aim of the study was to examine the propensity and selectivity of granule release from primed systemic eosinophils and neutrophils in allergic rhinitis and allergic asthma after seasonal and experimental allergen exposure. We hypothesize that the dissimilar clinical manifestations are due to diverse eosinophil and neutrophil degranulation.</p> <p>Methods</p> <p>Nine birch pollen allergic patients with rhinitis, eight with asthma and four controls were studied during pollen season and after nasal and bronchial allergen challenge. Eosinophils and neutrophils were incubated in vitro with assay buffer and opsonized Sephadex particles for spontaneous and C3b-induced granule protein release. The released amount of eosinophil cationic protein (ECP), eosinophil peroxidase (EPO) and myeloperoxidase (MPO) was measured by specific radioimmunoassay.</p> <p>Results</p> <p>C3b-induced degranulation resulted in increased release of ECP and MPO from primed blood eosinophils and neutrophils in both allergic rhinitis and allergic asthma during pollen season and after both nasal and bronchial challenge (p-values 0.008 to 0.043). After bronchial challenge, the ECP release was significantly higher in the rhinitic group compared to the asthmatic group [19.8 vs. 13.2%, (p = 0.010)]. The propensity for EPO release was weak in all challenge models but followed the same pattern in both allergic groups.</p> <p>Conclusions</p> <p>Systemically activated eosinophils and neutrophils have similar patterns of degranulation after allergen exposure in allergic rhinitis and allergic asthma. The released amount of ECP, EPO and MPO was similar in all allergen challenge models in both allergic groups. Our results indicate that other mechanisms than the magnitude of eosinophil and neutrophil inflammation or the degranulation pattern of the inflammatory cells determines whether or not an allergic patient develops asthma.</p

Anthrax, but Not Bacillus anthracis?

The article focuses on the other possible agents of anthrax aside from bacillus anthracis and other soil dwelling bacterium of the genus bacillus. It is stated that bacillus anthracis is a close relative of bacillus cereus and bacillus thuringiensis because of the presence of two large virulence plasmids, pXO1 and pXO2. The authors believe that bacillus cereus isolates can harbor either one or both of the B. anthracis plasmids, and they may or may not harbor anthrax toxin genes