Walking builds community cohesion: Survey of two New Hampshire communities looks at social capital and walkability

This brief reports the results of a survey conducted in 2009 of approximately 2,000 households in Portsmouth and Manchester, New Hampshire, to examine the connection between walkability and social capital. Authors Shannon Rogers, Kevin Gardner, and Cynthia Carlson report that higher levels of social capital are found in areas that are perceived to be more walkable, as measured by the number of places people can walk to in their community. In addition, walkability is influenced by concerns of safety, access, time, and health and by physical characteristics such as proximity, scale, and aesthetics. Given the link between walkability and greater social capital, and in turn the link between social capital and numerous positive outcomes, refitting communities with greater walkability can have short- and longer-term payoffs. The authors conclude that more walkable communities are healthier communities, and as the research in the brief shows, residents in them are more connected to one another not only by sidewalks but also through the social networks and social capital they form when they live in communities that encourage gathering and meeting face-to-face

Efficiency of the built environment: Interdependencies in transportation, development form and public health

Retrofitting existing neighborhoods and communities to remove barriers to walking and allow residents to choose walking as a mode of transportation has the potential to both stabilize energy used for transportation and transportation infrastructure and provide physical activity for improved health, shifting the energy used for transportation from cars to people. This study brings together community-based research, an interdisciplinary team approach, and multi-level modeling to investigate how community design impacts transportation behavior in the context of smaller, northeastern cities. Ten neighborhoods of varying design, connectivity, proximity to services, and average income were selected in each of the cities for a total of twenty neighborhoods studied. A survey of neighborhood residents provided demographic, health, and transportation behavior information. The built environment within the neighborhoods was analyzed using field visits and published GIS data. Data analysis included multi-level modeling to account for the within-neighborhood clustered design of data collection. Working together with the people for whom the results were intended allowed for use of a greater network of contacts for project development and implementation, which helped greatly. Involving municipal and regional authorities throughout the project increased the chances that results will be useful and will reach residents, and resulted in increased communication between the authorities themselves. Presence of sidewalks and intersections were found to be associated with the number of destinations respondents reported walking. Municipalities that would like to increase walking for public health or energy use reduction should investigate improving the condition and availability of sidewalks in neighborhoods, increasing connectivity of pedestrian ways, and improving safety and perceived security at intersections. Age appeared to be the most important demographic factor in decisions to walk, more important than self-reported health or income. Helping the elderly, as they age in place, to continue to feel secure through improved walking surfaces and walking environments could be a fruitful focus of municipal programs and initiatives

Parenting Practices of Resident Fathers: The Role of Marital and Biological Ties

This paper uses data from the Fragile Families and Child Wellbeing Study to examine differences in the parenting behaviors of resident biological and social fathers on measures of engagement, shared responsibility, and cooperation in parenting. Regression, difference-in-difference, and decomposition techniques are used. Results suggest that biological and social fathers differ significantly on most parenting measures (and in some unexpected ways), but that a considerable portion of these differences can be explained by differences in the background characteristics of the individuals and families in each group. Additionally, the analyses reveal a stronger link between marriage and higher-quality parenting behaviors for social-father families than for biological-father families.

Examining Walkability and Social Capital as Indicators of Quality of Life at the Municipal and Neighborhood Scales

Walkability has been linked to quality of life in many ways. Health related benefits of physical exercise, the accessibility and access benefits of being able to walk to obtain some of your daily needs, or the mental health and social benefits of reduced isolation are a few of the many positive impacts on quality of life that can result from a walkable neighborhood. In the age of increasing energy costs and climate considerations, the ability to walk to important locations is a key component of sustainable communities. While the health and environmental implications of walkable communities are being extensively studied, the social benefits have not been investigated as broadly. Social capital is a measure of an individual’s or group’s networks, personal connections, and involvement. Like economic and human capital, social capital is considered to have important values to both individuals and communities. Through a case study approach this article argues that the generation and maintenance of social capital is another important component of quality of life that may be facilitated by living in a walkable community. Residents living in neighborhoods of varying built form and thus varying levels of walkability in three communities in New Hampshire were surveyed about their levels of social capital and travel behaviors. Comparisons between the more walkable and less walkable neighborhoods show that levels of social capital are higher in more walkable neighborhoods

Allelic spectrum of the natural variation in CRP

With the recent completion of the International HapMap Project, many tools are in hand for genetic association studies seeking to test the common variant/common disease hypothesis. In contrast, very few tools and resources are in place for genotype–phenotype studies hypothesizing that rare variation has a large impact on the phenotype of interest. To create these tools for rare variant/common disease studies, much interest is being generated towards investing in re-sequencing either large sample sizes of random chromosomes or smaller sample sizes of patients with extreme phenotypes. As a case study for rare variant discovery in random chromosomes, we have re-sequenced ~1,000 chromosomes representing diverse populations for the gene C-reactive protein (CRP). CRP is an important gene in the fields of cardiovascular and inflammation genetics, and its size (~2 kb) makes it particularly amenable medical or deep re-sequencing. With these data, we explore several issues related to the present-day candidate gene association study including the benefits of complete SNP discovery, the effects of tagSNP selection across diverse populations, and completeness of dbSNP for CRP. Also, we show that while deep re-sequencing uncovers potentially medically relevant coding SNPs, these SNPs are fleetingly rare when genotyped in a population-based survey of 7,000 Americans (NHANES III). Collectively, these data suggest that several different types re-sequencing and genotyping approaches may be required to fully understand the complete spectrum of alleles that impact human phenotypes. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at http://dx.doi.org/10.1007/s00439-006-0160-y and is accessible for authorized users

Letrozole in the neoadjuvant setting: the P024 trial

Neoadjuvant chemotherapy trials have consistently reported lower response rates in hormone receptor-positive (HR+) breast cancer when compared with HR− cases. Preoperative endocrine therapy has therefore become a logical alternative and has gained considerable momentum from the finding that aromatase inhibitors (AIs) are more effective than tamoxifen for HR+ breast cancer in both the neoadjuvant and adjuvant settings. The most convincing neoadjuvant trial to demonstrate the superiority of an AI versus tamoxifen was the P024 study, a large multinational double-blind trial in postmenopausal women with HR+ breast cancer ineligible for breast-conserving surgery. The overall response rate (ORR) was 55% for letrozole and 36% for tamoxifen (P < 0.001). Significantly more letrozole-treated patients underwent breast-conserving surgery (45 vs. 35%, respectively; P = 0.022). In addition, ORR was significantly higher with letrozole than tamoxifen in the human epidermal growth factor receptor HER1/HER2+ subgroup (P = 0.0004). The clinical efficacy of letrozole in HER2+ breast cancer was confirmed by fluorescent in situ hybridization analysis and was found to be comparable to that of HER2− cases (ORR 71% in both subsets). Biomarker studies confirmed the superiority of letrozole in centrally assessed estrogen receptor-positive (ER+) tumors and found a strong relationship with the degree of ER positivity for both agents. Interestingly, letrozole was effective even in marginally ER+ tumors and, unlike tamoxifen, consistently reduced the expression from estrogen-regulated genes (progesterone receptor and trefoil factor 1). Furthermore, when analyzed by Ki67 immunohistochemistry, letrozole was significantly more effective than tamoxifen in reducing tumor proliferation (P = 0.0009). Thus, neoadjuvant letrozole is safe and superior to tamoxifen in the treatment of postmenopausal women with HR+ locally advanced breast cancer

The Sorcerer II Global Ocean Sampling Expedition: Metagenomic Characterization of Viruses within Aquatic Microbial Samples

Viruses are the most abundant biological entities on our planet. Interactions between viruses and their hosts impact several important biological processes in the world's oceans such as horizontal gene transfer, microbial diversity and biogeochemical cycling. Interrogation of microbial metagenomic sequence data collected as part of the Sorcerer II Global Ocean Expedition (GOS) revealed a high abundance of viral sequences, representing approximately 3% of the total predicted proteins. Cluster analyses of the viral sequences revealed hundreds to thousands of viral genes encoding various metabolic and cellular functions. Quantitative analyses of viral genes of host origin performed on the viral fraction of aquatic samples confirmed the viral nature of these sequences and suggested that significant portions of aquatic viral communities behave as reservoirs of such genetic material. Distributional and phylogenetic analyses of these host-derived viral sequences also suggested that viral acquisition of environmentally relevant genes of host origin is a more abundant and widespread phenomenon than previously appreciated. The predominant viral sequences identified within microbial fractions originated from tailed bacteriophages and exhibited varying global distributions according to viral family. Recruitment of GOS viral sequence fragments against 27 complete aquatic viral genomes revealed that only one reference bacteriophage genome was highly abundant and was closely related, but not identical, to the cyanomyovirus P-SSM4. The co-distribution across all sampling sites of P-SSM4-like sequences with the dominant ecotype of its host, Prochlorococcus supports the classification of the viral sequences as P-SSM4-like and suggests that this virus may influence the abundance, distribution and diversity of one of the most dominant components of picophytoplankton in oligotrophic oceans. In summary, the abundance and broad geographical distribution of viral sequences within microbial fractions, the prevalence of genes among viral sequences that encode microbial physiological function and their distinct phylogenetic distribution lend strong support to the notion that viral-mediated gene acquisition is a common and ongoing mechanism for generating microbial diversity in the marine environment

Developmental changes in human dopamine neurotransmission: cortical receptors and terminators

<p>Abstract</p> <p>Background</p> <p>Dopamine is integral to cognition, learning and memory, and dysfunctions of the frontal cortical dopamine system have been implicated in several developmental neuropsychiatric disorders. The dorsolateral prefrontal cortex (DLPFC) is critical for working memory which does not fully mature until the third decade of life. Few studies have reported on the normal development of the dopamine system in human DLPFC during postnatal life. We assessed pre- and postsynaptic components of the dopamine system including tyrosine hydroxylase, the dopamine receptors (D1, D2 short and D2 long isoforms, D4, D5), catechol-<it>O</it>-methyltransferase, and monoamine oxidase (A and B) in the developing human DLPFC (6 weeks -50 years).</p> <p>Results</p> <p>Gene expression was first analysed by microarray and then by quantitative real-time PCR. Protein expression was analysed by western blot. Protein levels for tyrosine hydroxylase peaked during the first year of life (p < 0.001) then gradually declined to adulthood. Similarly, mRNA levels of dopamine receptors D2S (p < 0.001) and D2L (p = 0.003) isoforms, monoamine oxidase A (p < 0.001) and catechol-<it>O</it>-methyltransferase (p = 0.024) were significantly higher in neonates and infants as was catechol-<it>O</it>-methyltransferase protein (32 kDa, p = 0.027). In contrast, dopamine D1 receptor mRNA correlated positively with age (p = 0.002) and dopamine D1 receptor protein expression increased throughout development (p < 0.001) with adults having the highest D1 protein levels (p ≤ 0.01). Monoamine oxidase B mRNA and protein (p < 0.001) levels also increased significantly throughout development. Interestingly, dopamine D5 receptor mRNA levels negatively correlated with age (r = -0.31, p = 0.018) in an expression profile opposite to that of the dopamine D1 receptor.</p> <p>Conclusions</p> <p>We find distinct developmental changes in key components of the dopamine system in DLPFC over postnatal life. Those genes that are highly expressed during the first year of postnatal life may influence and orchestrate the early development of cortical neural circuitry while genes portraying a pattern of increasing expression with age may indicate a role in DLPFC maturation and attainment of adult levels of cognitive function.</p