Univariate and multivariate analysis for variables potentially associated with the development of grade III-IV aGvHD.

<p>ALL: acute lymphoblastic leukemia; AML acute myeloid leukemia; MDS: myelodysplastic syndromes; MM: multiple myeloma; CML: chronic myeloid leukemia; SCT: stem cell transplantation; TBI: total body irradiation.</p><p>* p<0.05</p><p>Univariate and multivariate analysis for variables potentially associated with the development of grade III-IV aGvHD.</p

Influence of the genotype of the donor for the polymorphism (GT)_n in the promoter/enhancer of <i>FOXP3</i> on the outcome of allo-SCT.

<p><b>(A)</b> Cumulative incidence of grade III-IV GVHD. <b>(B)</b> Cumulative incidence of relapse. <b>(C-D)</b> Kaplan-Meier curves of event free survival (B) and overall survival (C).</p

Results of the luciferase assays performed to test influence of the number of repeats in the (GT)_n microsatellite polymorphism on the expression of the FOXP3 gene.

<p>The (GT)₁₅ allele produces significantly higher expression of the FOXP3 gene than the (GT)₁₆ allele.</p

Univariate analysis of the association between the presence of FOXP3 short alleles in the donor and the development of post-SCT complications.

<p>aGVHD: acute graft versus host disease; cGVHD: chronic GVHD.</p><p>(1)Seventeen patients died from infections. Data available for 12 patients, all of them due to bacterial infections, 5 died during the first year (range 2–10 months) and 7 died beyond the first year (range 15–48 months).</p><p>* p<0.05</p><p>Univariate analysis of the association between the presence of FOXP3 short alleles in the donor and the development of post-SCT complications.</p