Maternal factors associated with congenital <i>Trypanosoma cruzi</i> transmission risk.

<p>The limit of detection for the quantitative PCR assay was 1 parasite/mL. Parasite load values below this cutoff were assumed to be 0 for the purpose of analysis.</p><p>^aqPCR data were missing for 2 women who transmitted and 6 women who did not transmit to their infants. Four mother-infant pairs with ambiguous transmission status are excluded (see text).</p><p>Maternal factors associated with congenital <i>Trypanosoma cruzi</i> transmission risk.</p

Factors associated with estimated parasite load in blood of <i>T</i>. <i>cruzi</i>-infected mothers at the time of delivery.

<p>The limit of detection for the quantitative PCR assay was 1 parasite/mL. Parasite load values below this cutoff were assumed to be 0 for the purpose of analysis.</p><p>^aqPCR data were missing for 2 women who transmitted and 6 women who did not transmit to their infants. Four mother-infant pairs with ambiguous transmission status are excluded (see text).</p><p>^bComparison of parasite load distributions by maternal characteristic by Wilcoxon signed rank test.</p><p>^cComparison of years of exposure by parasite load category by Kruskal-Wallis test.</p><p>Factors associated with estimated parasite load in blood of <i>T</i>. <i>cruzi</i>-infected mothers at the time of delivery.</p

Characteristics of seropositive and seronegative study participants.

<p>^<b>a</b>Unadjusted results based on exact Pearson chi-square tests.</p><p>^<b>b</b>Adjusted results based on logistic regression, adjusted for gender and age as a quadratic function. Note that gender is adjusted for age as a quadratic function only. See text for explanation of age adjustment.</p><p>^<b>c</b>Data missing for 18 seropositive and 8 seronegative patients.</p><p>^<b>d</b>Data missing for 38 seropositive and 21 seronegative patients.</p><p>^<b>e</b>Data missing for 29 seropositive and 8 seronegative patients.</p><p>^<b>f</b>Data missing for 22 seropositive and 29 seronegative patients.</p

EKG and echocardiogram findings among patients with and without <i>Trypanosoma cruzi</i> infection.

a<p>Unadjusted results based on exact Pearson chi-square tests.</p>b<p>Adjusted results based on logistic regression, adjusted for sex and age as a quadratic function. See text for explanation of age adjustment.</p>c<p>EKG analyses include a total of 237 seropositive and 137 seronegative participants. 14 seropositive and 5 seronegative participants were excluded from the EKG analyses because they had implanted pacemakers.</p>d<p>Denominator for ‘any ventricular arrhythmia’ includes 14 seropositive and 5 seronegative participants with pacemakers excluded from the other EKG analyses.</p>e<p>Echochardiogram analyses include 229 seropositive and 127 seronegative participants.</p>f<p>Defined as end diastolic diameter >57 mm.</p>g<p>Defined as left atrial end diastolic diameter >40 mm not explained by diastolic dysfunction or left ventricular hypertrophy.</p>h<p>Data missing for one participant.</p

Multivariable model of characteristics associated with positive results on conventional <i>Trypanosoma cruzi</i> PCR among seropositive patients.

<p>Data missing for 96 patients.</p

Multivariable logistic regression model of factors associated with risk of <i>Trypanosoma cruzi</i> infection.

<p>Data missing for 7 patients.</p><p>^<b>a</b>Results for each risk factor are adjusted for other variables listed and for age as a quadratic function; see text for explanation.</p><p>^<b>b</b>Significant interaction between years of residence in an endemic area and housing. Risk associated with housing conditions evaluated holding years in endemic area fixed at the mean (45.2 years).</p