Synthesis of novel hybrid 1,5-disusbtituted 1<i>H-</i>tetrazol-5yl 4,5-dihydro [1,2,3]triazolo[1,5-<i>a</i>]pyrazin-6-ones <i>via</i> high-order MCR-S<i>_N</i>2/intramolecular [3 + 2] cycloaddition sequence

A facile and rapid synthesis of a family of new hybrid system 1,5-disusbtituted 1H-tetrazol-5yl 4,5-dihydro [1,2,3]triazolo[1,5-a]pyrazin-6-ones in moderate yields is described. Compounds were synthetized by a high-order multicomponent reaction (MCR) to give N-acylated 1,5-disubstituted tetrazoles followed, without chromatographic purification, by an SN2/intramolecular [3 + 2] cycloaddition sequence. The target molecules could be useful in drug discovery processes because they contain two very important pharmacophoric moieties: 1,5-disubstituted tetrazole and 1,2,3- triazole. </p