Gene network of known relationships among those genes differentially expressed in control- compared to vinclozolin lineage F3 generation germ cells.

<p>(A) E13 network, (B) E16 network. Gene node shape code: oval and circle – protein; diamond – ligand; irregular polygon – phosphatase; circle/oval on tripod platform – transcription factor; ice cream cone – receptor. Red colored nodes are up-regulated genes, blue color are down-regulated genes. Grey connecters represent general regulation, blue – expression regulation, purple – binding, green – promoter binding, orange – microRNA effect. Cell membrane, nucleus, mitochondria, endoplasmic reticulum and golgi localizations are indicated. Network was derived using Pathway Studio™ software.</p

Pathways enriched with F3 generation E13 and E16 germ cell gene lists.

<p>Pathways enriched with F3 generation E13 and E16 germ cell gene lists.</p

Known relationships between genes having DMR in their promoter regions (grey nodes) and differentially expressed genes (red nodes) in control- compared to vinclozolin lineage F3 generation germ cells from: (A) E13 and (B) E16.

<p>Gene node shape code: oval and circle – protein; diamond – ligand; circle/oval on tripod platform – transcription factor; ice cream cone – receptor. Grey connecters represent general regulation, blue – expression regulation, purple – binding, green – promoter binding. Network was derived using Pathway Studio™ software.</p

Olfactory Transduction Pathway showing olfactory receptor genes differentially expressed between F3 generation E13 PGC vinclozolin and control lineage rats.

<p>Adapted from Kyoto Encyclopedia of Genes and Genomes pathway rno04740.</p

DMR from (A) E13 PGC and (B) E16 germ cells.

<p>DMR from (A) E13 PGC and (B) E16 germ cells.</p