Correlation plots.

<p>A. Direct flow (DF) volume ratio (in relation to LVEDV) versus LVEDV index (LVEDVI). B. DF Kinetic energy (KE) ratio at ED versus LVEDVI. C. Non-ejecting (NE) volume ratio versus LVEDVI. D. NE KE ratio at ED versus LVEDVI.</p

Correlation between 4D flow measures and LV volumes.

<p>Correlation between 4D flow measures and LV volumes.</p

4D flow components.

<p>A. Schematic of the routes of the four LV flow components; direct flow (green), retained inflow (yellow), delayed ejection flow (blue), and residual volume (red). A semitransparent grayscale three-chamber image provides morphological orientation. Circles indicate the approximate location of the center of mass of each component at the time of end-diastole. B. Particle trace pathlines indicate routes of direct flow (green) and retained inflow (yellow). Red dots indicate the positions of the residual volume pathlines at end-diastole. Non-ejected flow comprises the retained inflow and the residual volume. Ao, aorta; LA, left atrium; LV, left ventricle.</p

The 4D flow components as proportions of total LV EDV (percent ± SD) in the three sub-groups stratified by LVEDVI.

<p>Non-ejecting volume is comprised of the Retained inflow (yellow) and Residual volume (red) flow components (yellow + red = orange). * P<0.05 vs Control group; † P<0.05 vs Lower LVEDVI group.</p

Sub-analysis with patients stratified according to Late Gadolinium Enhancement test.

<p>Sub-analysis with patients stratified according to Late Gadolinium Enhancement test.</p

Additional file 1 of Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women

Additional file 1: Figure S1. Directed Acyclical Graph (DAG) of confounding factors included in the analysis. Table S1. Definitions and categories of medical conditions in the analysis. Table S2. Characteristics and conditions in people included or excluded in the analyses. Table S3. Characteristics by sex. Table S4. Factors of interest by sex. Table S5. Characteristics by the presence of breathlessness in men. Table S6. Underlying conditions in relation to breathlessness in men. Table S7. Population attributable fractions of breathlessness related to underlying medical conditions in men. Table S8. Characteristics by the presence of breathlessness in women. Table S9. Underlying conditions in relation to breathlessness in women. Table S10. Population attributable fractions of breathlessness related to underlying medical conditions in women. Table S11. Characteristics by smoking history. Table S12. Factors of interest by smoking history. Table S13. Characteristics by the presence of breathlessness in neversmokers. Table S14. Underlying conditions in relation to breathlessness in never-smokers. Table S15. Population attributable fractions of breathlessness related to underlying medical conditions in never-smokers. Table S16. Characteristics by the presence of breathlessness in former smokers. Table S17. Underlying conditions in relation to breathlessness in former smokers. Table S18. Population attributable fractions of breathlessness related to underlying medical conditions in former smokers. Table S19. Characteristics by the presence of breathlessness in current smokers. Table S20. Underlying conditions in relation to breathlessness in current smokers. Table S21. Population attributable fractions of breathlessness related to underlying medical conditions in current smokers. Table S22. Characteristics by presence of self-reported cardiorespiratory disease. Table S23. Factors of interest by presence of self-reported cardiorespiratory disease. Table S24. Characteristics by the presence of breathlessness in people without self-reported cardiorespiratory disease. Table S25. Underlying conditions in relation to breathlessness in people without self-reported cardiorespiratory disease. Table S26. Population attributable fractions of breathlessness related to underlying medical conditions in people without self-reported cardiorespiratory disease. Table S27. Characteristics by the presence of breathlessness in people with self-reported cardiorespiratory disease. Table S28. Underlying conditions in relation to breathlessness in people with self-reported cardiorespiratory disease. Table S29. Population attributable fractions of breathlessness related to underlying medical conditions in people with self-reported cardiorespiratory disease