Serum IgE.

<p>(a) Total IgE levels in the eight different exposure groups. ** p<0.01, compared with the saline control; ## p<0.01, compared with the OVA only group; (b) Dose-response relationship between DEHP (+OVA) and total serum IgE levels; (c) OVA-IgE levels in the eight different exposure groups. Group data were expressed as means±standard deviation (SD). * p<0.05, ** p<0.01, compared with the saline control.</p

Multiple covariance analyses for AHR measurements.

<p>Covariance analyses were used for AHR testing. Dependent variable: biomarkers; Fixed factor: DEHP doses; Covariate: MCh doses.</p

The relative number of eosinophil to total cell numbers in BALF.

<p>Group data were expressed as means±standard deviation (SD). * p<0.05 and ** p<0.01, compared with the saline control; ^# p<0.05, compared with the OVA only group.</p

IFN-γ and IL-4 levels in lung tissue.

<p>(a) pulmonary tissue IFN-γ levels in each group; (b) pulmonary tissue IL-4 levels in each group; (c) IL-4/IFN-γ ratios in each group. Group data were expressed as means±standard deviation (SD). * p<0.05, ** p<0.01, compared with the saline control; ^# p<0.05, ^## p<0.01, compared with OVA only group.</p

Summary of the experimental results.

<p> <b>–: As statistical control group; Compared with saline control: NS p>0.05,</b></p>*<p> <b>p<0.05,</b></p>**<p> <b>p<0.01; Compared with OVA only group: ns p>0.05,</b></p>#<p> <b>p<0.05,</b></p>##<p> <b>p<0.01.</b></p

Airway hyperresponsiveness (AHR) measurements in mice.

<p>Covariance analyses (SPSS) were used in these tests. (a) Ri values of saline control and DEHP groups; (b) Re values of saline control and DEHP groups; (c) Cldyn values of saline control and DEHP groups; (d) Ri values of OVA only and OVA+DEHP groups; (e) Re values of OVA only and OVA+DEHP groups; (f) Cldyn values of OVA only and OVA+DEHP groups. Group data were expressed as means±standard deviation (SD).</p

Exposure and immunization schedule.

<p>Exposure and immunization schedule.</p

Additional file 1: of A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals

A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals. (DOCX 124 kb