Man, the Forgotten

Non-fiction by Carl W. White

Detecting paired and counterflow superfluidity via dipole oscillations

We suggest an experimentally feasible procedure to observe paired and counterflow superfluidity in ultra-cold atom systems. We study the time evolution of one-dimensional mixtures of bosonic atoms in an optical lattice following an abrupt displacement of an additional weak confining potential. We find that the dynamic responses of the paired superfluid phase for attractive inter-species interactions and the counterflow superfluid phase for repulsive interactions are qualitatively distinct and reflect the quasi long-range order that characterizes these states. These findings suggest a clear experimental procedure to detect these phases, and give an intuitive insight into their dynamics.Comment: 4 pages,5 figure

Human–Black Bear Conflicts: A Review of Common Management Practices

The objective of this monograph is to provide wildlife professionals, who respond to human–bear conflicts, with an appraisal of the most common techniques used for mitigating conflicts as well as the benefits and challenges of each technique in a single document. Most human–black bear conflict occurs when people make anthropogenic foods like garbage, dog food, domestic poultry, or fruit trees available to bears. Bears change their behavior to take advantage of these resources and may damage property or cause public safety concerns in the process. Managers and the public need to understand the available tools to stop human–bear conflict and reduce effects on bear populations.https://digitalcommons.usu.edu/hwi_monographs/1002/thumbnail.jp

CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes

© 2020 The Authors G protein-coupled receptors are a major class of membrane receptors that mediate physiological and pathophysiological cellular signaling. Many aspects of receptor activation and signaling can be investigated using genetically encoded luminescent fusion proteins. However, the use of these biosensors in live cell systems requires the exogenous expression of the tagged protein of interest. To maintain the normal cellular context here we use CRISPR/Cas9-mediated homology-directed repair to insert luminescent tags into the endogenous genome. Using NanoLuc and bioluminescence resonance energy transfer we demonstrate fluorescent ligand binding at genome-edited chemokine receptors. We also demonstrate that split-NanoLuc complementation can be used to investigate conformational changes and internalization of CXCR4 and that recruitment of β-arrestin2 to CXCR4 can be monitored when both proteins are natively expressed. These results show that genetically encoded luminescent biosensors can be used to investigate numerous aspects of receptor function at native expression levels

The rural almshouse population in Missouri

Cooperative rural research."June, 1938."This is a study of the rural almshouse in Missouri. The various types of almshouse administration and methods of inmate care are defined and described, together with the social characteristics of the inmate population. As a matter of considerable contemporary interest an analysis was made of the eligibility of inmates for old age assistance in order to determine the extent to which counties might be relieved of their inmate population through this type of public assistance. Examination of data on nearly 3,000 inmates indicated that more than one-half (52.4 per cent) were under 70 years of age which is the present minimum age limit for old age assistance. It was further determined that at least one-half of the ones eligible due to age were not likely to be approved for old age assistance since they were either physically or mentally disabled. It was concluded that less than one-fourth of the total inmate population might qualify for old age assistance and that additional provisions would be necessary if the rural counties are to be relieved of the care of their almshouse population.By C.T. Pihlblad, Arthur W. Nebel, and Joseph H. Stokes, in collaboration with Melvin W. Sneed and Cecil L. Gregory.Cooperative Rural Research ... The Agricultural Experiment Station, University of Missouri; The Rural Section, Division of Social Research, Federal Works Progress Administration; and the State Social Security Commission of Missouri Cooperating.Introduction -- Administration and control -- Personnel and management -- Almshouses and almshouse inmates -- Eligibility of inmates for old age assistance -- Consolidation of almshouses -- Suggested recommendations -- Appendix

SERCA2 Regulates Non-CF and CF Airway Epithelial Cell Response to Ozone

Calcium mobilization can regulate a wide range of essential functions of respiratory epithelium, including ion transport, ciliary beat frequency, and secretion of mucus, all of which are modified in cystic fibrosis (CF). SERCA2, an important controller of calcium signaling, is deficient in CF epithelium. We conducted this study to determine whether SERCA2 deficiency can modulate airway epithelial responses to environmental oxidants such as ozone. This could contribute to the pathogenesis of pulmonary exacerbations, which are important and frequent clinical events in CF. To address this, we used air-liquid interface (ALI) cultures of non-CF and CF cell lines, as well as differentiated cultures of cells derived from non-CF and CF patients. We found that ozone exposure caused enhanced membrane damage, mitochondrial dysfunction and apoptotic cell death in CF airway epithelial cell lines relative to non-CF. Ozone exposure caused increased proinflammatory cytokine production in CF airway epithelial cell lines. Elevated proinflammatory cytokine production also was observed in shRNA-mediated SERCA2 knockdown cells. Overexpression of SERCA2 reversed ozone-induced proinflammatory cytokine production. Ozone-induced proinflammatory cytokine production was NF-κB- dependent. In a stable NF-κB reporter cell line, SERCA2 inhibition and knockdown both upregulated cytomix-induced NF-κB activity, indicating importance of SERCA2 in modulating NF-κB activity. In this system, increased NF-κB activity was also accompanied by increased IL-8 production. Ozone also induced NF-κB activity and IL-8 release, an effect that was greater in SERCA2-silenced NF-κB-reporter cells. SERCA2 overexpression reversed cytomix-induced increased IL-8 release and total nuclear p65 in CFTR-deficient (16HBE-AS) cells. These studies suggest that SERCA2 is an important regulator of the proinflammatory response of airway epithelial cells and could be a potential therapeutic target

Assessing simulation ecosystem processes for climate variability research at Glacier National Park

Glacier National Park served as a test site for ecosystem analyses that involved a suite of integrated models embedded within a geographic information system. The goal of the exercise was to provide managers with maps that could illustrate probable shifts in vegetation, net primary production (NPP), and hydrologic responses associated with two selected climatic scenarios. The climatic scenarios were (a) a recent 12-yr record of weather data, and (b) a reconstituted set that sequentially introduced in repeated 3-yr intervals wetter–cooler, drier–warmer, and typical conditions. To extrapolate the implications of changes in ecosystem processes and resulting growth and distribution of vegetation and snowpack, the model incorporated geographic data. With underlying digital elevation maps, soil depth and texture, extrapolated climate, and current information on vegetation types and satellite-derived estimates of leaf area indices, simulations were extended to envision how the park might look after 120 yr. The predictions of change included underlying processes affecting the availability of water and nitrogen. Considerable field data were acquired to compare with model predictions under current climatic conditions. In general, the integrated landscape models of ecosystem processes had good agreement with measured NPP, snowpack, and streamflow, but the exercise revealed the difficulty and necessity of averaging point measurements across landscapes to achieve comparable results with modeled values. Under the extremely variable climate scenario significant changes in vegetation composition and growth as well as hydrologic responses were predicted across the park. In particular, a general rise in both the upper and lower limits of treeline was predicted. These shifts would probably occur along with a variety of disturbances (fire, insect, and disease outbreaks) as predictions of physiological stress (water, nutrients, light) altered competitive relations and hydrologic responses. The use of integrated landscape models applied in this exercise should provide managers with insights into the underlying processes important in maintaining community structure, and at the same time, locate where changes on the landscape are most likely to occur

Magnetron priming by multiple cathodes

A relativistic magnetron priming technique using multiple cathodes is simulated with a three-dimensional, fully electromagnetic, particle-in-cell code. This technique is based on electron emission from N/2N∕2 individual cathodes in an NN-cavity magnetron to prime the ππ mode. In the case of the six-cavity relativistic magnetron, ππ-mode start-oscillation times are reduced up to a factor of 4, and mode competition is suppressed. Most significantly, the highest microwave field power is observed by utilizing three cathodes compared to other recently explored priming techniques.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87840/2/081501_1.pd

The Ursinus Weekly, October 11, 1954

The Night of January 16th to be Curtain Club Fall play • Gayle Livingstone wins essay award • History Department starts Bible study group • Fraternity row • IRC invites students • Beemer, Ramsey get NR commission • WSGA classified Bermuda shorts • God, our help in ages past theme for weekend retreat • Chem. society opens term • Y \u27s plan for \u2754-\u2755 • FTA to hold first meeting • Forum on October 31st • Maples and Lynnewood have new preceptresses • Editorials • Cub and Key celebrate 15th anniversary • Debators campaign • Paolone sets \u2754-\u2755 MSGA in motion • P-T day • Band lays plans for Old Timers\u27 Day • Maintenance men active • French Club to meet Tues. • Continental observer • Price of originality • Volume XXII of The Lantern • Captain Stadler, hockey gals out to beat 1-loss 1953 mark • Ehlers\u27 passing nets Curtis lead in grid campaign • Don\u27t buy your spirit, we have it for free! • Conti, Carver break away to blank Crusaders, 12-0 • Fall volleyball replaces hockey in intramurals • Fumble, blocked kicks aid Drexel win: Dragons maul Bears 41-13; Hart, Campiglia big guns • Booters down Hill School in 5-1 opener; Four back • Stick gals bow to Beaver 5-3 after injury to Ruth Heller • Emerald gals use teamwork in 7-0 victory • Chess Club elects Scheirer new prexy • Aregood to preside over first Chi Alpha meeting • Frosh united? • Want an activity? Join the Y • Robert Sutton new librarianhttps://digitalcommons.ursinus.edu/weekly/1455/thumbnail.jp