Correlation between growth inhibition and tracer-uptake reduction after 3 days of treatment (1 and 10 μM)

<p><b>Copyright information:</b></p><p>Taken from "Application of the multicellular tumour spheroid model to screen PET tracers for analysis of early response of chemotherapy in breast cancer"</p><p>http://breast-cancer-research.com/content/9/4/R45</p><p>Breast cancer research : BCR 2007;9(4):R45-R45.</p><p>Published online 22 Jul 2007</p><p>PMCID:PMC2206720.</p><p></p

The dose effect of treatment with docetaxel and doxorubicin recorded with FLT

<p><b>Copyright information:</b></p><p>Taken from "Application of the multicellular tumour spheroid model to screen PET tracers for analysis of early response of chemotherapy in breast cancer"</p><p>http://breast-cancer-research.com/content/9/4/R45</p><p>Breast cancer research : BCR 2007;9(4):R45-R45.</p><p>Published online 22 Jul 2007</p><p>PMCID:PMC2206720.</p><p></p

Radiation dose distribution in coronary arteries in breast cancer radiotherapy

<p><b>Background:</b> Women irradiated for left-sided breast cancer (BC) have an increased risk of coronary artery disease compared to women with right-sided BC. We describe the distribution of radiation dose in segments of coronary arteries in women receiving adjuvant radiotherapy (RT) for left- or right-sided BC.</p> <p><b>Material and methods:</b> Fifteen women with BC, seven left-sided and eight right-sided, who had received three-dimensional conformal radiotherapy (3DCRT), constituted the study base. The heart and the segments of the coronary arteries were defined as separate organs at risk (OAR), and the mean and maximum radiation doses were calculated for each OAR.</p> <p><b>Results:</b> In women with left-sided BC, irrespective of if regional lymph node RT was given or not, maximum dose in mid and distal left anterior descending artery (mdLAD) was approximately 50 Gy in 6/7 patients, whereas women with right-sided BC mainly received low doses of radiation. In women with left-sided BC, 6/7 patients had substantially higher mean dose to the distal LAD than to the heart, ranging from 30 to 55 Gy and 3 to13 Gy, respectively.</p> <p><b>Conclusion:</b> We found a pronounced difference of radiation dose distribution in the coronary arteries between women with left- and right-sided BC. Women with left-sided BC had almost full treatment dose in parts of mdLAD, regardless of if regional lymph node irradiation was given or not, while women with right-sided BC mainly received low doses to the coronary arteries.</p

Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk-1

<p><b>Copyright information:</b></p><p>Taken from "Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk"</p><p>http://www.biomedcentral.com/1471-2407/8/6</p><p>BMC Cancer 2008;8():6-6.</p><p>Published online 14 Jan 2008</p><p>PMCID:PMC2254632.</p><p></p> and population controls. Meta-analysis of reported case control studies in Caucasian breast cancer samples and population controls (which are in agreement with HWE)

Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk-0

<p><b>Copyright information:</b></p><p>Taken from "Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk"</p><p>http://www.biomedcentral.com/1471-2407/8/6</p><p>BMC Cancer 2008;8():6-6.</p><p>Published online 14 Jan 2008</p><p>PMCID:PMC2254632.</p><p></p> and population controls. Meta-analysis of reported case control studies in Caucasian breast cancer samples and population controls (which are in agreement with HWE)

Manhattan plot of results from genome wide meta-analysis of POSH stage-1 and HEBCS hazard ratios and 95% confidence intervals.

<p>The 25 most associated SNPs are highlighted in green.</p

Associations of SNPs with nominal replication signals with clinical characteristics associated with breast cancer in a pooled set of discovery and replication cohorts.

<p>N-stage = metastasis to lymph node, M-stage = metastasis stage and T-stage = Tumour stage.</p><p>Associations of SNPs with nominal replication signals with clinical characteristics associated with breast cancer in a pooled set of discovery and replication cohorts.</p

Kaplan-Meier plots depicting breast cancer related survival in response to rs421379 genotypes in pooled POSH stage-1, HEBCS and POSH stage-2 samples.

<p>Kaplan-Meier plots depicting breast cancer related survival in response to rs421379 genotypes in pooled POSH stage-1, HEBCS and POSH stage-2 samples.</p

Replication of most significant associations from the discovery set meta-analysis in the replication samples.

<p>Results are presented for those SNPs which remained associated in the same direction in the validation set as in the discovery set (adjusted for ER-status).</p><p>Replication of most significant associations from the discovery set meta-analysis in the replication samples.</p

Additional file 5: Table S2. of A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients

Associations between SNP and breast cancer-specific mortality by radiotherapy for interactions showing p <0.1 (LRT)$ in the MARIE study and results of replication in BCAC studies. (DOCX 20 kb