Delineation of the arcuate fasciculus (AF).

<p>Panel (A) illustrates the 3D lateral view of the brain in pink and the AF bundle is colored in yellow. The AF extends from the temporal lobe (labeled as “T”) to the frontal lobe (labeled as “F”). Panels (B, C) show the coronal and axial slices of the mean DTI color map, where the ROI boundaries in orange are shown for the AF delineation.</p

White matter measures of the arcuate fasciculus (AF) using diffusion tensor imaging (DTI).

<p>Abbreviations: AD, axial diffusivity; AF, arcuate fasciculus; DTI, diffusion tensor imaging; FA, fractional anisotropy; LI, lateralization indices.</p

Lateralization index (LI) profiles of the arcuate fasciculus (AF) in fronto (F)-temporal (T) span and their correlations with clinical scores.

<p>On the top row of columns (A, B), the black line denotes the LI profile averaged over healthy controls, while the red line denotes the profile averaged over patients with schizophrenia. The regions in gray denotes the anatomical locations with significant lateralization away from zero at p<0.05 after Bonferroni correction as marked by the dashed line on the bottom row of columns (A, B). On panel (C), the AF superimposed on the 3D lateral view of the brain is colored in yellow for left lateralization and in green for right lateralization. On the top row of columns (D–G), the line denotes correlation profile with clinical scores in patients with schizophrenia. The regions in gray denotes the anatomical locations with significant correlations with clinical scores at p<0.05 after Bonferroni correction as marked by the dashed line on the bottow row of columns (D–G). Arrows on panels (H, I) point to the AF locations with significant correlations shown on panels (D, F, G).</p

Tract-based analysis of DTI measures along the arcuate fasciculus (AF).

<p>On the top row of columns (A–D) the black line denotes the profile averaged over healthy controls, while the red line denotes the profile averaged over patients with schizophrenia. The region in gray denotes the anatomical location with significant group difference at p<0.05 after Bonferroni correction as marked by the dashed line on the bottom row of columns (A–D). The x-axis coordinates on panels (A–D) are normalized by the arc length of the AF. Panel (E) shows the triangle corresponding to the AF loci with a significant difference between healthy controls and patients with schizophrenia.</p