BLyS serum levels in human obesity.

<p>(A) represents significant differences between different grades of obesity (grade 1+2 (BMI≥30 to <40 kg/m²), n = 20 and grade 3 (BMI≥40 kg/m²), n = 42) and normal-weight ((BMI≤25 kg/m²), n = 10) human control subjects. (B) shows the correlation (<i>r</i> = 0.43, p<0.0002) between BLyS serum levels and BMI of n = 72 human subjects used in this study. Data in this figure are shown as means+SD.</p

Baseline characteristics of the study populations of the BLyS mRNA in human total adipose tissue biopsies of lean, grade 3 obese +/− insulin resistance (IR) and of BLyS measurements in sera of lean, grade 1+2 obese +/− insulin resistance.

<p>t₁: lean vs. obese.</p><p>t₂: lean vs. obese+IR.</p><p>t₃: obese vs. obese+IR.</p><p>Shown are means+SD for each group.</p

BLyS mRNA level in (A) visceral and (B) subcutaneous adipose tissue of lean control subjects, patients with grade 3 obesity +/− type 2 diabetes (T2D).

<p>RNA was isolated from total subcutaneous and visceral adipose tissue biopsies. Data in this figure are shown as means+SD. (C) shows a significant negative correlation between age and BLyS expression (<i>r</i> = −0.48, p<0.0001) in a combined analysis of all biopsy samples.</p