Assessing plantar sensation in the foot using the FOot Roughness Discrimination Test (FoRDT™): a reliability and validity study in stroke

BACKGROUND: The foot sole represents a sensory dynamometric map and is essential for balance and gait control. Sensory impairments are common, yet often difficult to quantify in neurological conditions, particularly stroke. A functionally oriented and quantifiable assessment, the Foot Roughness Discrimination Test (FoRDT™), was developed to address these shortcomings. OBJECTIVE: To evaluate inter- and intra-rater reliability, convergent and discriminant validity of the Foot Roughness Discrimination Test (FoRDT™). DESIGN: Test-retest design. SETTING: Hospital Outpatient. PARTICIPANTS: Thirty-two people with stroke (mean age 70) at least 3 months after stroke, and 32 healthy, age-matched controls (mean age 70). MAIN OUTCOME MEASURES: Roughness discrimination thresholds were quantified utilising acrylic foot plates, laser-cut to produce graded spatial gratings. Stroke participants were tested on three occasions, and by two different raters. Inter- and intra-rater reliability and agreement were evaluated with Intraclass Correlation Coefficients and Bland-Altman plots. Convergent validity was evaluated through Spearman rank correlation coefficients (rho) between the FoRDT™ and the Erasmus modified Nottingham Sensory Assessment (EmNSA). RESULTS: Intra- and inter rater reliability and agreement were excellent (ICC =.86 (95% CI .72-.92) and .90 (95% CI .76 -.96)). Discriminant validity was demonstrated through significant differences in FoRDT™ between stroke and control participants (p.05). CONCLUSIONS: This simple and functionally oriented test of plantar sensation is reliable, valid and clinically feasible for use in an ambulatory, chronic stroke and elderly population. It offers clinicians and researchers a sensitive and robust sensory measure and may further support the evaluation of rehabilitation targeting foot sensation. This article is protected by copyright. All rights reserved

The Impact of Triclosan on the Spread of Antibiotic Resistance in the Environment

Triclosan (TCS) is a commonly used antimicrobial agent that enters wastewater treatment plants (WWTPs) and the environment. An estimated 1.1 × 105 to 4.2 × 105 kg of TCS are discharged from these WWTPs per year in the United States. The abundance of TCS along with its antimicrobial properties have given rise to concern regarding its impact on antibiotic resistance in the environment. The objective of this review is to assess the state of knowledge regarding the impact of TCS on multidrug resistance in environmental settings, including engineered environments such as anaerobic digesters. Pure culture studies are reviewed in this paper to gain insight into the substantially smaller body of research surrounding the impacts of TCS on environmental microbial communities. Pure culture studies, mainly on pathogenic strains of bacteria, demonstrate that TCS is often associated with multidrug resistance. Research is lacking to quantify the current impacts of TCS discharge to the environment, but it is known that resistance to TCS and multidrug resistance can increase in environmental microbial communities exposed to TCS. Research plans are proposed to quantitatively define the conditions under which TCS selects for multidrug resistance in the environment

Interview with Carey A. Moore, December 30, 2003

Carey A. Moore was interviewed on December 30, 2003 by Michael Birkner about his experiences after leaving Gettysburg College and moving on ultimately toward a Ph.D and then a teaching career. Length of Interview: 94 minutes Collection Note: This oral history was selected from the Oral History Collection maintained by Special Collections & College Archives. Transcripts are available for browsing in the Special Collections Reading Room, 4th floor, Musselman Library. GettDigital contains the complete listing of oral histories done from 1978 to the present. To view this list and to access selected digital versions please visit -- http://gettysburg.cdmhost.com/cdm/landingpage/collection/p16274coll

Altered Antibiotic Tolerance in Anaerobic Digesters Acclimated to Triclosan Or Triclocarban

Bench-scale anaerobic digesters were amended to elevated steady-state concentrations of triclosan (850 mg/kg) and triclocarban (150 mg/kg) using a synthetic feed. After more than 9 solids retention time (SRT) values of acclimatization, biomass from each digester (and a control digester that received no antimicrobials) was used to assess the toxicity of three antibiotics. Methane production rate was measured as a surrogate for activity in microcosms that received doses of antibiotics ranging from no-antibiotic to inhibitory concentrations. Biomass amended with triclocarban was more sensitive to tetracycline compared to the control indicating synergistic inhibitory effects between this antibiotic and triclocarban. In contrast, biomass amended with triclosan was able to tolerate statistically higher levels of ciprofloxacin indicating that triclosan can induce functional resistance to ciprofloxacin in an anaerobic digester community

Spectroscopic infrared extinction mapping as a probe of grain growth in IRDCs

We present spectroscopic tests of MIR to FIR extinction laws in IRDC G028.36+00.07, a potential site of massive star and star cluster formation. Lim & Tan (2014) developed methods of FIR extinction mapping of this source using ${\it Spitzer}$-MIPS ${\rm 24\mu m}$ and ${\it Herschel}$-PACS ${\rm 70\mu m}$ images, and by comparing to MIR ${\it Spitzer}$-IRAC $3$--${\rm 8\mu m}$ extinction maps, found tentative evidence for grain growth in the highest mass surface density regions. Here we present results of spectroscopic infrared extinction (SIREX) mapping using ${\it Spitzer}$-IRS (14 to ${\rm 38\mu m}$) data of the same IRDC. These methods allow us to first measure the SED of the diffuse Galactic ISM that is in the foreground of the IRDC. We then carry out our primary investigation of measuring the MIR to FIR opacity law and searching for potential variations as a function of mass surface density within the IRDC. We find relatively flat, featureless MIR-FIR opacity laws that lack the $\sim{\rm 12\mu m}$ and $\sim{\rm 35\mu m}$ features associated with the thick water ice mantle models of Ossenkopf & Henning (1994). Their thin ice mantle models and the coagulating aggregate dust models of Ormel et al. (2011) are a generally better match to the observed opacity laws. We also find evidence for generally flatter MIR to FIR extinction laws as mass surface density increases, strengthening the evidence for grain and ice mantle growth in higher density regions.Comment: 12 pages, 12 Figures, 1 Table, Accepted to be published to Ap

Uplift Quadratic Program in Irish Electricity Price Setting

Bord Gis required a deeper insight into the dynamics of Uplift prices. The aim of the group was to apply a variety of analytical tools to the problem in order to satisfy Bord Gis requirements. The group conducted a KKT Optimality Analysis of the quadratic program used to determine the Uplift prices, performed statistical analysis to identify the binding constraints and their sensitives to the Uplift prices, simulated a synthetic stochastic process that is consistent with the Uplift pricing series and investigated alternative objective functions for the quadratic program

Pairwise Well-Formed Modes and Transformations

One of the most significant attitudinal shifts in the history of music occurred in the Renaissance, when an emerging triadic consciousness moved musicians towards a new scalar formation that placed major thirds on a par with perfect fifths. In this paper we revisit the confrontation between the two idealized scalar and modal conceptions, that of the ancient and medieval world and that of the early modern world, associated especially with Zarlino. We do this at an abstract level, in the language of algebraic combinatorics on words. In scale theory the juxtaposition is between well-formed and pairwise well-formed scales and modes, expressed in terms of Christoffel words or standard words and their conjugates, and the special Sturmian morphisms that generate them. Pairwise well-formed scales are encoded by words over a three-letter alphabet, and in our generalization we introduce special positive automorphisms of $F3$, the free group over three letters.Comment: 12 pages, 3 figures, paper presented at the MCM2017 at UNAM in Mexico City on June 27, 2017, keywords: pairwise well-formed scales and modes, well-formed scales and modes, well-formed words, Christoffel words, standard words, central words, algebraic combinatorics on words, special Sturmian morphism