Spitzer Warm Mission Workshop Introduction

The Spitzer Warm Mission Workshop was held June 4–5, 2007, to explore the science drivers for the warm Spitzer mission and help the Spitzer Science Center develop a new science operations philosophy. We must continue to maximize the science return with the reduced resources available, both using (a) the shortest two IRAC channels, and (b) archival research with the rich Spitzer archive. This paper summarizes the overview slides presented to the workshop participant

Analysis of prehistoric brown earth paleosols under the podzol soils of Exmoor, UK

The deforestation of the upland landscapes in southwest Britain during prehistory is an established archaeological narrative, documenting human impacts on the environment and questioning the relationship of prehistoric societies to the upland landscapes they inhabited. Allied to the paleoenvironmental analyses of pollen sequences, which have provided the evidence of this change, there has been some investigation of prehistoric paleosols fossilized under principally Bronze Age archaeological monuments. These analyses identified brown earth soils that were originally associated with temperate deciduous woodland, on occasion showing evidence of human impacts such as tilling. However, the number of analyses of these paleosols has been limited. This study presents the first analysis of a series of pre‐podzol brown earth paleosols on Exmoor, UK, two of which are associated with colluvial soil erosion sediments before the formation of peat. This study indicates these paleosols are spatially extensive and have considerable potential to inform a more nuanced understanding of prehistoric human impacts on the upland environments of the early‐mid Holocene and assess human agency in driving ecosystem change

Bridging the Gap from New Graduate to Practicing Occupational Therapist: An Educational Resource in Orthopedics

OT is pivotal in the rehabilitation and recovery of individuals with orthopedic conditions (Nelson, 2010). However, as a new graduate occupational therapist, there is limited support as they make the transition to clinical practice (Turpin et al., 2021). New graduates receive support through professional mentorship and peer support but are often focused on the safe practice of basic skills rather than on best practices (Opoku et al., 2021). New graduates would feel more confident in clinical judgment and decision-making with additional support from mentors and accessible up-to-date resources (Adam et al., 2013). Purpose: Develop an accessible resource for new occupational therapists entering the orthopedic setting.https://soar.usa.edu/otdcapstonesfall2023/1009/thumbnail.jp

Biology, Metastatic Patterns, and Treatment of Patients with Triple-Negative Breast Cancer

Of the estimated 1 million cases of breast cancer diagnosed annually worldwide, it is estimated that over 170,000 will harbor the triple-negative (estrogen receptor/progesterone receptor/HER2–negative) phenotype. Most, though not all, triple-negative breast cancers will be basal-like on gene expression micorarrays. The basal-like molecular subtype exhibits a unique molecular profile and set of risk factors, aggressive and early pattern of metastasis, limited treatment options, and poor prognosis. Large population-based studies have identified a higher proportion of triple-negative breast tumors among premenopausal African American women, and a suggestion that increased parity, younger age at first-term pregnancy, shorter duration of breast feeding, and elevated hip-to-waist ratio might be particular risk factors. When BRCA1 mutation carriers develop breast cancer, it is usually basal-like; given the central role of BRCA1 in DNA repair, this could have profound therapeutic implications. When diagnosed, triple-negative breast cancers illustrate preferential relapse in visceral organs, including the central nervous system. Although initial response to chemotherapy might be more profound, relapse is early and common among triple-negative breast cancers compared with luminal breast cancers. The armamentarium of “targeted therapeutics” for triple-negative breast cancer is evolving and includes strategies to inhibit angiogenesis, epidermal growth factor receptor, and other kinases. Finally, the positive association between triple-negative breast cancer and BRCA mutations makes inhibition of poly(adenosine diphosphate-ribose) polymerase–1 an attractive therapeutic strategy that is in active study

Clinical trial update: implications and management of residual disease after neoadjuvant therapy for breast cancer

Neoadjuvant chemotherapy for breast cancer has a well-established role in the management of patients with locally advanced or early stage disease. Multiple trials have demonstrated superior survival outcomes in individuals achieving a pathologic complete response at the time of definitive surgery, and sophisticated genetic methods may predict which patients will be in this category. Those with less than a pathologic complete response remain at significant risk of recurrent disease, and currently no further standard therapy exists. Ongoing studies of novel agents may lead to improved therapeutic outcomes for this high-risk population

Addressing ALS Caregiver Needs: An Occupation-Based Caregiver Education Program

This program adds a new component to the Les Turner ALS Foundation’s already established online educational programs. The foundation had a program for people living with ALS but did not have a program for caregivers prior to this project. A needs assessment was completed to determine caregiver needs and materials for caregivers were developed based on the needs found. The materials developed were implemented with ten caregivers to determine effectiveness and outcomes before launching the program to the general public.https://soar.usa.edu/otdcapstones-spring2022/1004/thumbnail.jp

Pixel level decorrelation in service of the Spitzer microlens parallax survey

Microlens parallax measurements combining space-based and ground-based observatories can be used to study planetary demographics. In recent years, the Spitzer Space Telescope was used as a microlens parallax satellite. Meanwhile, Spitzer IRAC has been employed to study short-period exoplanets and their atmospheres. As these investigations require exquisite photometry, they motivated the development of numerous self-calibration techniques now widely used in the exoplanet atmosphere community. Specifically, pixel level decorrelation (PLD) was developed for starring-mode observations in uncrowded fields. We adapt and extend PLD to make it suitable for observations obtained as part of the Spitzer Microlens Parallax Campaign. We apply our method to two previously published microlensing events, OGLE-2017-BLG-1140 and OGLE-2015-BLG-0448, and compare its performance to the state-of-the-art pipeline used to analyses Spitzer microlensing observation. We find that our method yields photometry 1.5–6 times as precise as previously published. In addition to being useful for Spitzer, a similar approach could improve microlensing photometry with the forthcoming Nancy Grace Roman Space Telescope

Pixel level decorrelation in service of the Spitzer microlens parallax survey

Microlens parallax measurements combining space-based and ground-based observatories can be used to study planetary demographics. In recent years, the Spitzer Space Telescope was used as a microlens parallax satellite. Meanwhile, Spitzer IRAC has been employed to study short-period exoplanets and their atmospheres. As these investigations require exquisite photometry, they motivated the development of numerous self-calibration techniques now widely used in the exoplanet atmosphere community. Specifically, pixel level decorrelation (PLD) was developed for starring-mode observations in uncrowded fields. We adapt and extend PLD to make it suitable for observations obtained as part of the Spitzer Microlens Parallax Campaign. We apply our method to two previously published microlensing events, OGLE-2017-BLG-1140 and OGLE-2015-BLG-0448, and compare its performance to the state-of-the-art pipeline used to analyses Spitzer microlensing observation. We find that our method yields photometry 1.5–6 times as precise as previously published. In addition to being useful for Spitzer, a similar approach could improve microlensing photometry with the forthcoming Nancy Grace Roman Space Telescope