Feasibility of the REDCap platform for Single Center and Collaborative Multicenter CMR Research

REDCap (Research Enterprise Data CAPture) software may provide a feasible platform for CMR Centers to: a) capture clinical throughput securely for research purposes, and 2) collaborate using a common platform for either distributed or centralized data storage. REDCap may facilitate CMR Centers' participation in the research enterprise, especially those with limited resources. REDCap may catalyze multicenter studies with "distributed data collection" where CMR sites can clone shared data dictionaries across sites for subsequent compilation into a singular master data file

Biom Biostat Int J

CC999999/Intramural CDC HHS/United States2016-06-17T00:00:00Z27331197PMC491222

'Splenic switch-off' to detect adenosine understress; a novel method to improve test sensitivity

The sensitivity of adenosine perfusion CMR is reduced by false negative scans, with up to 50% resulting from inadequate pharmacological stress. Without a robust physiological marker for adequate myocardial hyperaemia, this false negative rate is difficult to address. We observed that splenic perfusion is markedly attenuated with adenosine - compared both to rest and to myocardial perfusion. In this collaborative multi-center study, we investigate the pharmacology of 'splenic switch-off', and evaluate its potential clinical utility as a marker of inadequate stress in adenosine perfusion imaging