Prescriptions for Off-Shell Bosonic String Amplitudes

We give, in the framework of the bosonic string theory, simple prescriptions for computing, at tree and one-loop levels, off-shell string amplitudes for open and closed string massless states. In particular we obtain a tree amplitude for three open strings that in the field theory limit coincides with the three-gluon vertex in the usual covariant gauge and two-string one-loop amplitudes satisfying the property of transversality.Comment: 11 pages, LaTeX, to appear in the proceedings of the workshop "Quantum Aspects of Gauge Theories, Supersymmetry and Unification", Corfu (Greece), 20-26 September 1998. Eq. (12) and numerical factors in eqs. (13) and (16) corrected; some minor changes and references adde

Off-shell amplitudes for nonoriented closed strings

In the context of the bosonic closed string theory, by using the operatorial formalism, we give a simple expression of the off-shell amplitude with an arbitrary number of external massless states inserted on the Klein bottle

Generating Functional for Strong and Nonleptonic Weak Interactions

The generating functional for Green functions of quark currents is given in closed form to next-to-leading order in the low-energy expansion for chiral SU(3), including one-loop amplitudes with up to three meson propagators. Matrix elements and form factors for strong and nonleptonic weak processes with at most six external states can be extracted from this functional by performing three-dimensional flavour traces. To implement this procedure, a Mathematica program is provided that evaluates amplitudes with at most six external mesons, photons (real or virtual) and virtual W (semileptonic form factors). The program is illustrated with several examples that can be compared with existing calculations.Comment: 26 pages; references added, comparison with other programs added, small changes in the text, version to appear in JHE

In Search of Differential Inhibitors of Aldose Reductase

Aldose reductase, classified within the aldo-keto reductase family as AKR1B1, is an NADPH dependent enzyme that catalyzes the reduction of hydrophilic as well as hydrophobic aldehydes. AKR1B1 is the first enzyme of the so-called polyol pathway that allows the conversion of glucose into sorbitol, which in turn is oxidized to fructose by sorbitol dehydrogenase. The activation of the polyol pathway in hyperglycemic conditions is generally accepted as the event that is responsible for a series of long-term complications of diabetes such as retinopathy, cataract, nephropathy and neuropathy. The role of AKR1B1 in the onset of diabetic complications has made this enzyme the target for the development of molecules capable of inhibiting its activity. Virtually all synthesized compounds have so far failed as drugs for the treatment of diabetic complications. This failure may be partly due to the ability of AKR1B1 to reduce alkenals and alkanals, produced in oxidative stress conditions, thus acting as a detoxifying agent. In recent years we have proposed an alternative approach to the inhibition of AKR1B1, suggesting the possibility of a differential inhibition of the enzyme through molecules able to preferentially inhibit the reduction of either hydrophilic or hydrophobic substrates. The rationale and examples of this new generation of aldose reductase differential inhibitors (ARDIs) are presented

The antimicrobial peptide temporin G: Anti-biofilm, anti-persister activities, and potentiator effect of tobramycin efficacy against Staphylococcus aureus

Bacterial biofilms are a serious threat for human health, and the Gram-positive bacterium Staphylococcus aureus is one of the microorganisms that can easily switch from a planktonic to a sessile lifestyle, providing protection from a large variety of adverse environmental conditions. Dormant non-dividing cells with low metabolic activity, named persisters, are tolerant to antibiotic treatment and are the principal cause of recalcitrant and resistant infections, including skin infections. Antimicrobial peptides (AMPs) hold promise as new anti-infective agents to treat such infections. Here for the first time, we investigated the activity of the frog-skin AMP temporin G (TG) against preformed S. aureus biofilm including persisters, as well as its efficacy in combination with tobramycin, in inhibiting S. aureus growth. TG was found to provoke ~50 to 100% reduction of biofilm viability in the concentration range from 12.5 to 100 µM vs ATCC and clinical isolates and to be active against persister cells (about 70–80% killing at 50–100 µM). Notably, sub-inhibitory concentrations of TG in combination with tobramycin were able to significantly reduce S. aureus growth, potentiating the antibiotic power. No critical cytotoxicity was detected when TG was tested in vitro up to 100 µM against human keratinocytes, confirming its safety profile for the development of a new potential anti-infective drug, especially for treatment of bacterial skin infections

Induced quantum gravity on a Riemann Surface

Induced quantum gravity dynamics built over a Riemann surface is studied in arbitrary dimension. Local coordinates on the target space are given by means of the Laguerre-Forsyth construction. A simple model is proposed and pertubatively quantized. In doing so, the classical W-symmetry turns out to be preserved on-shell at any order of the $\hbar$ perturbative expansion. As a main result, due to quantum corrections, the target coordinates acquire a non-trivial character.Comment: LaTex, 32 pages, no figures, submitted to Int. J. Mod. Phys.

The Gabor wave front set of compactly supported distributions

We show that the Gabor wave front set of a compactly supported distribution equals zero times the projection on the second variable of the classical wave front set