2 research outputs found
Traveling Masculinities on the Summit: Reappropriations and Disarticulations of Mountain Climbing Visions in “The Alps of Granada” (1868–1900)
Physiological and Pathological Vascular Aging
Aging is a risk factor for cardiovascular diseases. Through aging, blood vessels become stiffer, less
elastic and, thus, with less ability to contract. The objectives of this chapter are to review (i) recent
progresses in the characterization of physiological and pathological vascular aging and (ii) in vitro
platforms to study vascular aging. Initially, we will discuss the causes and biomarkers of vascular
aging. Then we will discuss the main characteristics related to physiological and pathological aging
including (i) altered ECM remodeling (e.g. composition, mechanical properties, degradation,
calcification of the ECM during aging), (ii) enhanced fibrosis (e.g. causes and mechanisms), (iii)
vascular cell dysfunction triggered by chronic oxidative stress, inflammation or senescence, and (iv)
altered responses of vascular cells to flow shear stress. Finally, we will discuss in vitro systems to
study vascular aging, particularly the effect of biomechanics in aged cells as well as the effect of
drugs during vascular aging