6 research outputs found
PNEUMOCOCCAL SEROTYPES AMONG FILIPINO CHILDREN ADMITTED TO A TERTIARY CARE CENTER FOR INFECTIOUS DISEASES IN 2000-2005
PNEUMOCOCCAL SEROTYPES AMONG FILIPINO CHILDREN ADMITTED IN A TERTIARY CARE CENTER FOR INFECTIOUS DISEASES FROM 2000 TO 2005
Antibody responses of three Haemophilus influenzae type b conjugate vaccines after one, two and three doses in Filipino children
Evaluation of sampling sites for detection of upper respiratory tract carriage of Streptococcus pneumoniae and Haemophilus influenzae
Evaluation of the immunogenicity and safety of an indigenously developed DTwP-Hib tetravalent combination vaccine (Shan 4) with Easyfourâ„¢ in Indian infants administered per EPI schedule: A phase III trial
The study was planned to assess and compare immunogenicity and safety of an indigenous DTPw-Hib combination vaccine (Shan 4) with EasyFour, the available DTwP-Hib vaccine in India. Overall 210 healthy infants, six to eight weeks of age, were randomized to receive three doses of either Shan 4 or EasyFour at 6, 10 and 14 weeks of age. Antibodies were analyzed prior to and four to six weeks post third vaccine dose. Solicited and unsolicited local and systemic events in the follow up period after each dose were recorded. Post vaccination 100% of the infants in Shan 4 and EasyFour groups had seroprotective concentrations of Anti PRP-T IgG antibodies, IgG anti-diphtheria toxoid antibodies and IgG anti-tetanus toxoid antibodies. Following third dose of vaccination 86.99% subjects in the Shan 4 group and 73.85% subjects in the EasyFour group seroconverted for anti-pertussis antibody titres. Two Serious Adverse Events (SAEs) were reported during the course of the study, all unrelated to the respective vaccine administered. Most commonly reported adverse events in both the groups were pain at injection site, mild fever (<103°F) and minor swelling at injection site. The study proved that Shan 4 was safe and immunogenic compared to the available licensed vaccine