Demand uncertainty In modelling WDS: scaling laws and scenario generation

Water distribution systems (WDS) are critical infrastructures that should be designed to work properly in different conditions. The design and management of WDS should take into account the uncertain nature of some system parameters affecting the overall reliability of these infrastructures. In this context, water demand represents the major source of uncertainty. Thus, uncertain demand should be either modelled as a stochastic process or characterized using statistical tools. In this paper, we extend to the 3rd and 4th order moments the analytical equations (namely scaling laws) expressing the dependency of the statistical moments of demand signals on the sampling time resolution and on the number of served users. Also, we describe how the probability density function (pdf) of the demand signal changes with both the increase of the user’s number and the sampling rate variation. With this aim, synthetic data and real indoor water demand data are used. The scaling laws of the water demand statistics are a powerful tool which allows us to incorporate the demand uncertainty in the optimization models for a sustainable management of WDS. Specifically, in the stochastic/robust optimization, solutions close to the optimum in different working conditions should be considered. Obviously, the results of these optimization models are strongly dependent on the conditions that are taken into consideration (i.e. the scenarios). Among the approaches for the definition of demand scenarios and their probability-weight of occurrence, the moment-matching method is based on matching a set of statistical properties, e.g. moments from the 1st (mean) to the 4th (kurtosis) order

Bright light exposure reduces TH-positive dopamine neurons: Implications of light pollution in Parkinson\u27s disease epidemiology

This study explores the effect of continuous exposure to bright light on neuromelanin formation and dopamine neuron survival in the substantia nigra. Twenty-one days after birth, Sprague–Dawley albino rats were divided into groups and raised under different conditions of light exposure. At the end of the irradiation period, rats were sacrificed and assayed for neuromelanin formation and number of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra. The rats exposed to bright light for 20 days or 90 days showed a relatively greater number of neuromelanin-positive neurons. Surprisingly, TH-positive neurons decreased progressively in the substantia nigra reaching a significant 29% reduction after 90 days of continuous bright light exposure. This decrease was paralleled by a diminution of dopamine and its metabolite in the striatum. Remarkably, in preliminary analysis that accounted for population density, the age and race adjusted Parkinson's disease prevalence significantly correlated with average satellite-observed sky light pollution

Bright light exposure reduces TH-positive dopamine neurons: implications of light pollution in Parkinson's disease epidemiology.

This study explores the effect of continuous exposure to bright light on neuromelanin formation and dopamine neuron survival in the substantia nigra. Twenty-one days after birth, Sprague-Dawley albino rats were divided into groups and raised under different conditions of light exposure. At the end of the irradiation period, rats were sacrificed and assayed for neuromelanin formation and number of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra. The rats exposed to bright light for 20 days or 90 days showed a relatively greater number of neuromelanin-positive neurons. Surprisingly, TH-positive neurons decreased progressively in the substantia nigra reaching a significant 29% reduction after 90 days of continuous bright light exposure. This decrease was paralleled by a diminution of dopamine and its metabolite in the striatum. Remarkably, in preliminary analysis that accounted for population density, the age and race adjusted Parkinson's disease prevalence significantly correlated with average satellite-observed sky light pollution

Fluorescent light induces neurodegeneration in the rodent nigrostriatal system but near infrared LED light does not

We investigated the effects of continuous artificial light exposure on the mouse substantia nigra (SN). A three month exposure of C57Bl/6J mice to white fluorescent light induced a 30% reduction in dopamine (DA) neurons in SN compared to controls, accompanied by a decrease of DA and its metabolites in the striatum. After six months of exposure, neurodegeneration progressed slightly, but the level of DA returned to the basal level, while the metabolites increased with respect to the control. Three month exposure to near infrared LED light (∼710 nm) did not alter DA neurons in SN, nor did it decrease DA and its metabolites in the striatum. Furthermore mesencephalic cell viability, as tested by [3H]DA uptake, did not change. Finally, we observed that 710 nm LED light, locally conveyed in the rat SN, could modulate the firing activity of extracellular-recorded DA neurons. These data suggest that light can be detrimental or beneficial to DA neurons in SN, depending on the source and wavelength

Memorie di ricerche antiquarie nella tenuta della «Sepoltura di Nerone» (1780-1796) tratte dall'archivio del Capitolo Vaticano

Viene posta in risalto l'importanza, sul piano documentario (con specifico riferimento alla scienza antiquaria), dell'archivio del Capitolo di S. Pietro, veneranda istituzione, titolare, per secoli, di un vastissimo comprensorio della Campagna Romana. Nel caso della tenuta della Sepoltura di Nerone, la preziosa documentazione archivistica ha contribuito ad un migliore inquadramento delle esplorazioni archeologiche tardo-settecentesche nell'area, fornendo inediti ragguagli in merito alle campagne di scavo, susseguitesi nel periodo 1780-1783 nonché dando notizia di ulteriori (mal conosciuti) interventi in loc