34,763 research outputs found

    Innovation Institution and Spatial Transfer of Energy Industry: The Case of Jiangsu Province, China

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    This study aims to explore the effect of innovation institution on spatial transfer of energy industry in Jiangsu, China. We focus on the disparity of innovation and energy industry, and analyze the spatial transfer difference in different types of energy industry, rather than view energy industry as a whole. The study demonstrates the spatial change of energy industry at regional level and maps the spatial pattern at city level. The study chooses intellectual property rights (IPRs) protection intensity, authorization patents and local research and development (R&D) investment as the proxy of innovation. Using official data and employing panel fixed-effect model at city-industry level, we conclude (a) innovation abilities significantly influence the spatial transfer of energy industry in Jiangsu. Especially, due to the different time, IPRs protection, patent counts, and R&D investment have different effects on different regions in Jiangsu; (b) 2010 is an important turning point for energy industry development in Jiangsu, and after 2010, the energy industry begins to shift to the middle and northern Jiangsu, whereas the spatial pattern of energy industry in coastal cities is basically unchanged; (c) there is a great difference between the regions in Jiangsu Province, and industrial upgrading has not been achieved in northern Jiangsu

    Orbitally-driven Behavior: Mott Transition, Quantum Oscillations and Colossal Magnetoresistance in Bilayered Ca3Ru2O7

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    We report recent transport and thermodynamic experiments over a wide range of temperatures for the Mott-like system Ca3Ru2O7 at high magnetic fields, B, up to 30 T. This work reveals a rich and highly anisotropic phase diagram, where applying B along the a-, b-, and c-axis leads to vastly different behavior. A fully spin-polarized state via a first order metamagnetic transition is obtained for B||a, and colossal magnetoresistance is seen for B||b, and quantum oscillations in the resistivity are observed for B||c, respectively. The interplay of the lattice, orbital and spin degrees of freedom are believed to give rise to this strongly anisotropic behavior.Comment: 26 pages and 8 figure

    Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.

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    DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent protein degradation, is phosphorylated by DNA-PK and recruited to DNA double-strand break sites to regulate DNA damage repair. However, it is not clear whether VCP is involved in DNA-PKcs (DNA-PK catalytic subunit) degradation or whether it regulates the radiosensitivity of glioblastoma. Our data demonstrated that DNA-PKcs was ubiquitinated and bound to VCP. VCP knockdown resulted in the accumulation of the DNA-PKcs protein in glioblastoma cells, and the proteasome inhibitor MG132 synergised this increase. As expected, this increase promoted the efficiency of DNA repair in several glioblastoma cell lines; in turn, this enhanced activity decreased the radiation sensitivity and prolonged the survival fraction of glioblastoma cells in vitro. Moreover, the VCP knockdown in glioblastoma cells reduced the survival time of the xenografted mice with radiation treatment relative to the control xenografted glioblastoma mice. In addition, the VCP protein was also downregulated in ~25% of GBM tissues from patients (WHO, grade IV astrocytoma), and the VCP protein level was correlated with patient survival (R(2)=0.5222, P<0.05). These findings demonstrated that VCP regulates DNA-PKcs degradation and increases the sensitivity of GBM cells to radiation

    Finite dimensional integrable Hamiltonian systems associated with DSI equation by Bargmann constraints

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    The Davey-Stewartson I equation is a typical integrable equation in 2+1 dimensions. Its Lax system being essentially in 1+1 dimensional form has been found through nonlinearization from 2+1 dimensions to 1+1 dimensions. In the present paper, this essentially 1+1 dimensional Lax system is further nonlinearized into 1+0 dimensional Hamiltonian systems by taking the Bargmann constraints. It is shown that the resulting 1+0 dimensional Hamiltonian systems are completely integrable in Liouville sense by finding a full set of integrals of motion and proving their functional independence.Comment: 10 pages, in LaTeX, to be published in J. Phys. Soc. Jpn. 70 (2001
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